Background: A simple score was proposed recently for Predicting Early Mortality from Ischemic Stroke (PREMISE) derived from the Austrian Stroke Unit Registry. This score could be useful in clinical practice and research. However, its generalizability is uncertain, as it was validated internally only. Aims: We aimed to validate the PREMISE score externally. Methods: The analysis was performed in the Athens Stroke Registry. The PREMISE score was calculated as described in the original publication.

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