Objective: The role of heparin in acute ischemic stroke is controversial. We investigated the effect of heparin on ischemic lesion growth. Methods: Data were analyzed on nonthrombolyzed ischemic stroke patients in whom diffusion-weighted imaging (DWI)/perfusion-weighted imaging (PWI) MRI was performed less than 12hours of last known well and showed a PWI-DWI lesion mismatch, and who underwent follow-up neuroimaging at least 4days after admission. Lesion growth was assessed by (1) absolute lesion growth and (2) percentage mismatch lost (PML).

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