Chen, D. T., Worrall, B. B. September 3, 2017

In this study, Thomalla et al.1 compare baseline characteristics of participants providing informed consent with those enrolled by surrogate permission (legal guardian, next of kin, investigator and independent physician, or just investigator) from the first 1,005 participants enrolled in WAKE-UP, a multinational European clinical trial of MRI-based thrombolysis in stroke patients with unknown time of onset. In accordance with European and national regulations, multiple options for obtaining consent were made available.


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