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March 2024

Medical professionals Traumatic brain injury
Complexities of Post-Concussion Syndrome: Risk Factors, Recovery Predictors, and the Need for Personalized Care

by Ioannis Mavroudis March 22, 2024

by Ioannis Mavroudis March 22, 2024

post-concussion syndrome, PCS, traumatic brain injury, TBI, risk factors, recovery, gender differences, mental health, migraines, …

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Medical professionals Traumatic brain injury
Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

by Ioannis Mavroudis March 22, 2024

by Ioannis Mavroudis March 22, 2024

Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

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Cognitive impairment Medical professionals Traumatic brain injury
Chronic Cognitive Impairment Following Traumatic Brain Injury: A Closer Look

by Ioannis Mavroudis March 9, 2024

by Ioannis Mavroudis March 9, 2024

This article provides a comprehensive analysis of the multifaceted impacts of traumatic brain injury (TBI), …

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Medical professionals Traumatic brain injury
Brain Pathology in the Context of Concussion History

by Ioannis Mavroudis March 1, 2024

by Ioannis Mavroudis March 1, 2024

Exploring the intricate relationship between concussion history and brain pathology reveals a complex interplay of …

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Non-invasive vagus nerve stimulation is associated with the reduction in persistent post-concussion symptoms: an observational study
INTRODUCTION: Traumatic brain injury (TBI) remains a major public health challenge, with mild TBI (mTBI) frequently resulting in persistent cognitive, affective, and somatic symptoms. Non-invasive vagus nerve stimulation (nVNS) has demonstrated potential in reducing neuroinflammation and promoting recovery in preclinical TBI models. This retrospective, observational study assessed the impact of adjunctive nVNS on postconcussive symptoms […]
Spautin-1 alleviates depression-like behaviors in mice after traumatic brain injury by inhibiting MMP3 expression in microglia in the Hippocampal CA1 region
CONCLUSIONS: Spautin-1 alleviates depression-like behaviors in mice following mild TBI by inhibiting the MMP3 signaling pathway in microglia within the CA1 region of the hippocampus, indicating a potential therapeutic strategy for addressing post-TBI depression.
Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip
Traumatic brain injuries (TBIs) are a risk factor for Alzheimer's disease (AD), and share several important pathological features including the development of neurofibrillary tangles (NFT) of tau protein. While this association is well established, the underlying pathogenesis is poorly defined and current treatment options remain limited, necessitating novel methods and approaches. In response we developed […]
Detecting mild traumatic brain injury with MEG scan data: One-vs-K-sample tests
Magnetoencephalography (MEG) scanner has been shown to be more accurate than other medical devices in detecting mild traumatic brain injury (mTBI). However, MEG scan data in certain spectrum ranges can be skewed, multimodal, and heterogeneous which can mislead the conventional case-control analysis that requires the data to be homogeneous and normally distributed within the control […]
Risk of Mortality Among Adult Females Diagnosed with Traumatic Brain Injury in an Academic Medical System
The objective of this retrospective cohort study was to evaluate mortality risk over five years among 6,432 female patients with a health care encounter diagnosis of TBI from hospitals and outpatient clinics within a university health system. We used TBI severity, defined by the Centers for Disease Control and Department of Defense/Veterans Affairs: mild, moderate/severe/penetrating, […]

March 2024

Complexities of Post-Concussion Syndrome: Risk Factors, Recovery Predictors, and the Need for Personalized Care

Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

Chronic Cognitive Impairment Following Traumatic Brain Injury: A Closer Look

Brain Pathology in the Context of Concussion History