Stephen B. Shrewsbury, Maria Jeleva, Kelsey H. Satterly, Jason Lickliter, John Hoekman January 19, 2019


Investigate the safety and pharmacokinetics (PK) of INP104, intranasal dihydroergotamine mesylate (DHE) administered via a Precision Olfactory Delivery (POD®) device, (Impel NeuroPharma, Seattle, WA) vs intravenous (IV) DHE and DHE nasal spray (Migranal®) in healthy adult subjects.… Read More...

Mario F.P. Peres, Arão Belitardo Oliveira, Juliane P. Mercante, Helder H. Kamei, Patricia R. Tobo, Todd D. Rozen, Morris Levin, Dawn C. Buse, Giancarlo Lucchetti January 19, 2019


Optimism and pessimism are related to several mental health and brain disorders, are significant predictors of physical and psychological health outcomes, and implicated as psychosocial determinants of the pain experience. Despite this promising evidence, limited information is available on optimism and pessimism in headache disorders.… Read More...

Alicia Gonzalez‐Martinez, Daniel Romero‐Palacián, Julio Dotor García‐Soto, Pedro Sánchez, Gemma Reig Roselló, Gustavo Zapata Wainberg January 18, 2019


To report a case of reversible cerebral vasoconstriction syndrome (RCVS) possibly precipitated by tocilizumab.


Immunosuppressant drugs are a rare cause of reversible cerebral vasoconstriction, a syndrome characterized by segmental vasospasm. However, although it is considered a reversible process that resolves within 3 months, the cerebral vasoconstriction over time may lead to severe complications such as strokes.… Read More...

Kai‐Uwe Kern, Myriam Schwickert‐Nieswandt, Christian Maihöfner, Charly Gaul January 18, 2019


Trigeminal neuralgia is difficult to treat and shows upregulation of sodium channels. The expectorant ambroxol acts as a strong local anesthetic, about 40 times stronger than lidocaine. It preferentially inhibits the channel subtype Nav1.8, expressed especially in nociceptive C‐fibers.… Read More...

Carmen Fourier, Caroline Ran, Anna Steinberg, Christina Sjöstrand, Elisabet Waldenlind, Andrea Carmine Belin January 17, 2019


The purpose of this study was to investigate the HCRTR2 gene variants rs3122156, rs2653342, and rs2653349 in a large homogenous Swedish case‐control cohort in order to further evaluate the possible contribution of HCRTR2 to cluster headache.


Cluster headache is a severe neurovascular disorder and the pathophysiology is not yet fully understood.… Read More...

Wei He, Yixin Zhang, Ting Long, Qi Pan, Shanshan Zhang, Jiying Zhou January 12, 2019


Structural damage or demyelization of the sphenopalatine ganglion may cause sphenopalatine neuralgia (SN). The current International Classification of Headache Disorders, third edition (ICHD‐3) regards SN as a phenotype of cluster headache. Whether SN is an independent neuralgia entity has been debated for years.… Read More...

Stuart M. Pearson, Mark J. Burish, Robert E. Shapiro, Yuanqing Yan, Larry I. Schor January 11, 2019


To assess the effectiveness and adverse effects of acute cluster headache medications in a large international sample, including recommended treatments such as oxygen, commonly used medications such as opioids, and emerging medications such as intranasal ketamine. Particular focus is paid to a large subset of respondents 65 years of age or older.… Read More...

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