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History of violence/maltreatment and psychogenic non-epileptic seizures
Massimiliano Beghi, Le Zhang, Ettore Beghi, Giorgia Giussani, Giuseppe Erba, Elisa Longinetti, Brian M. D'Onofrio, Elisa Bianchi, Fang Fang, Torbjorn Tomson, Zheng Chang
0
Psychogenic non-epileptic seizures (PNES) are paroxysmal alterations of behavior that resemble epileptic seizures but lack a neurobiological origin and are not associated with electrophysiological ictal abnormalities . According to the…
The value of rapid eye movement sleep in the localization of epileptogenic foci for patients with…
Epilepsy is one of the common neurological diseases, characterized by abnormally synchronized discharges of brain neurons . There are more than 50 million epileptic patients worldwide, 30% of whom are refractory , and the poor therapeutic…
Orbitofrontal cortex encodes preference for alcohol
Orbitofrontal cortex (OFC) plays a key role in representation and regulation of reward value, preference, and seeking. OFC function is disrupted in drug use and dependence, but its specific role in alcohol use disorders has not been…
Multi-dimensional tuning in motor cortical neurons during active behavior
A region within songbird cortex, AId (dorsal intermediate arcopallium), is functionally analogous to motor cortex in mammals and has been implicated in song learning during development. Non-vocal factors such as visual and social cues are…
Gain and loss of abilities in type II SMA: a 12-month natural history study
Giorgia Coratti, Simona Lucibello, Maria C Pera, Tina Duong, Robert Muni Lofra, Matthew Civitello, Adele D'Amico, Nathalie Goemans, Basil T Darras, Claudio Bruno, Valeria A Sansone, John Day, Andres Nascimento Osorio, Francesco Muntoni, Claudio Bruno, Richard Finkel, Eugenio Mercuri, ISMAC group
0
Spinal muscular atrophy (SMA) is an autosomal recessive, progressive neurodegenerative disease caused by mutations in the survival motor neuron 1 gene (SMN1) and characterized by the degeneration of α-motor neurons in the spinal cord.
Cortical Representations of Conspecific Sex Shape Social Behavior
Kingsbury et al. find that prefrontal cortex neurons represent the sex of conspecifics during social interaction. Male animals show stronger encoding of female than male cues, which predicts their behavioral preference toward interaction…
Deep Reinforcement Learning and Its Neuroscientific Implications
Recent advances in artificial intelligence have unified the fields of reinforcement learning and deep learning. The result, deep reinforcement learning, has far-reaching implications for neuroscience. Botvinick et al. introduce deep…
Ictal Blinking in Focal Seizures: insights from SEEG recordings
Stanislas Lagarde, Maya Dirani, Agnès Trebuchon, Anne Lepine, Nathalie Villeneuve, Didier Scavarda, Romain Carron, Aileen McGonigal, Fabrice Bartolomei
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Ictal blinking is an oculomotor sign occurring in various types of epilepsies . A blink consists of tonic closure of upper and lower eyelid, co-occurring with downward movement of the eyes (contraction of orbicularis oculi and levator…
Neonatal Apneic Phenotype in a Murine Congenital Central Hypoventilation Syndrome Model is Induced…
Diego Alzate‐Correa,
Jillian Liu,
Mikayla Jones,
Talita M. Silva,
Michele Joana Alves,
Elizabeth Burke,
Jessica Zuñiga,
Behiye Kaya,
Giuliana Zaza,
Mehmet Tahir Aslan,
Jessica Blackburn,
Marina Y. Shimada,
Silvio A. Fernandes‐Junior,
Lisa A. Baer,
Kristin I. Stanford,
Amber Kempton,
Sakima Smith,
Caroline C Szujewski,
Abby Silbaugh,
Jean‐Charles Viemari,
Ana C. Takakura,
Alfredo J. Garcia,
Thiago S. Moreira,
Catherine M. Czeisler,
José J. Otero
0
Abstract
Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder usually caused by mutations in the homeodomain transcription factor PHOX2B . Some CCHS patients suffer mainly from deficiencies in CO2 and/or O2…
Considerations for integrative multi‐omic approaches to explore Alzheimer’s disease mechanisms
Abstract
The past decade has seen the maturation of multiple different forms of high‐dimensional molecular profiling to the point that these methods could be deployed in initially hundreds and more recently thousands of human samples. In…