Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis
Background and Objectives Costimulation by CD40 and its ligand CD40L (CD154) is important for the functional differentiation of T cells. Preclinical studies have recognized the…
Limb myorhythmia from spinal cord glioma
A 26-year-old man gave a 4-week history of involuntary movements in the right arm (figure 1), manifesting as slow rhythmic, painless spasms of abduction. He…
Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage
Background and purpose Signal transducer and activator of transcription 3 (STAT3) may contribute to the proinflammation in the central nervous system diseases by modulating the…
Quantitative angiographic haemodynamic evaluation of bypasses for complex aneurysms: a preliminary study
Objective Open microsurgery, often with bypass techniques, is indispensable for complex aneurysms. To date, it remains unknown whether arterial anatomy or quantitative blood flow measurements…
Safety of endovascular therapy for symptomatic intracranial artery stenosis: a national prospective registry
Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown. The Clinical Registration Trial of Intracranial Stenting…
Teriflunomide Promotes Oligodendroglial 8,9-Unsaturated Sterol Accumulation and CNS Remyelination
Background and Objectives To test whether low concentrations of teriflunomide (TF) could promote remyelination, we investigate the effect of TF on oligodendrocyte in culture and…
Autopsy Case of Meningoencephalomyelitis Associated With Glial Fibrillary Acidic Protein Antibody
Background and Objectives To describe the autopsy findings and neuropathologic evaluation of autoimmune meningoencephalomyelitis associated with glial fibrillary acidic protein (GFAP) antibody. Methods We reviewed…
Revealing the Timeline of Structural MRI Changes in Premanifest to Manifest Huntington Disease
Background and Objectives Longitudinal measurements of brain atrophy using structural MRI (sMRI) can provide powerful markers for tracking disease progression in neurodegenerative diseases. In this…
Diagnostic Criteria for Small Fiber Neuropathy
Objectives: Despite its relative common occurrence, definitive diagnosis of small fiber neuropathy (SFN) remains problematic. In practice, patients with pain, numbness, and/or paresthesias in their…
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