Quality of life outcomes after subthalamic stimulation in Parkinson’s disease depends on age

ABSTRACT

Objective

The purpose of this study was to investigate how quality of life outcome after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson’s disease (PD) depends on age.

Methods

In this prospective, open-label, multicenter study including 120 PD patients undergoing bilateral STN-DBS, we investigated the PDQuestionnaire-8 (PDQ-8), Unified PD Rating Scale-III, Scales for Outcomes in PD–motor examination, complications, activities of daily living, and levodopa equivalent daily dose preoperatively and at 5 months follow-up.

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Survival in patients with Parkinson’s disease after deep brain stimulation or medical management

ABSTRACT

Objective: Deep brain stimulation has been shown to have a significant long-term beneficial effect on motor function. However, whether it affects survival is not clear. In this study, we compared survival rates for Parkinson’s disease (PD) patients who underwent deep brain stimulation (DBS) with those who were medically managed.

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Directional local field potentials: A tool to optimize deep brain stimulation

ABSTRACT

Background: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.

Objectives: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.

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Enhanced mu opioid receptor–dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia

ABSTRACT

Background: Mu opioid receptor activation modulates acetylcholine release in the dorsal striatum, an area deeply involved in motor function, habit formation, and reinforcement learning as well as in the pathophysiology of different movement disorders, such as dystonia. Although the role of opioids in drug reward and addiction is well established, their involvement in motor dysfunction remains largely unexplored.

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Predicting the onset of freezing of gait: A longitudinal study

ABSTRACT

Background: Freezing of gait is a disabling symptom of Parkinson’s disease that ultimately affects approximately 80% of patients, yet very little research has focused on predicting the onset of freezing of gait and tracking the longitudinal progression of symptoms prior to its onset.

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