Poor sleep is a frequent complaint of patients with psychogenic non-epileptic seizures (PNES). Our group has recently reported that PNES subjects more frequently complained of poor sleep patterns relative to those with epilepsy [1], however the study was limited by use of a single item from the Beck Depression Inventory to assess changes in sleep patterns.… Read More...

Background: Recent studies have suggested that patients with chronic rhinosinusitis (CRS) may have a higher risk of stroke although the data are still limited. The current systematic review and meta-analysis was conducted with the aims to identify all studies that investigated this relationship and summarize their results together to better characterize the risk of stroke among patients with CRS.… Read More...

Background: Stroke is a common neurological complication of infective endocarditis (IE) and it is associated with increased morbidity and mortality but infective endocarditis in acute stroke setting is hard to discover. Material and methods: A 75-year-old man referred to hospital for the onset of left hemiparesis and dysarthria.… Read More...

Background: The effect of serum rheumatoid factor (RF) on poststroke cognitive impairment remains unknown. We aimed to investigate the association of serum RF in the acute phase with cognitive impairment at 3 months after ischemic stroke onset. Methods: Our study was based on a random sample from the China Antihypertensive Trial in Acute Ischemic Stroke, a total of 582 patients from 7 of 26 participating sites of the trial with serum RF levels were included in this analysis.… Read More...

ABSTRACT

Background

Laboratory and clinical evidence indicate that continous delivery of levodopa is associated with reduced motor complications compared to standard intermittent levodopa.

Objective

To assess the pharmacokinetics and efficacy of continuous oral delivery of l‐dopa/carbidopa in PD patients with motor fluctuations.… Read More...

Abstract

Background

The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.… Read More...

ABSTRACT

Spread of α‐synuclein pathology from the peripheral to central nervous system may be an important etiological factor in Parkinson’s disease, although there are some unanswered questions about its correlation with neuronal loss. Experimental evidence has highlighted the gastrointestinal tract as a potential starting point for aggregated α‐synuclein, with the vagus nerve acting as a “highway” by which pathology may be transmitted to the lower brain stem.… Read More...

ABSTRACT

Objective

To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson’s disease (PD).

Background

The International Parkinson and Movement Disorder Society Evidence‐Based Medicine Committee’s recommendations for treatments of PD were first published in 2002, updated in 2011, and now updated again through December 31, 2016.… Read More...

Anelia A. Y. Kassi, Anil K. Mahavadi, Angelica Clavijo, Daniela Caliz, Stephanie W. Lee, Aminul I. Ahmed, Shoji Yokobori, Zhen Hu, Markus S. Spurlock, Joseph M Wasserman, Karla N. Rivera, Samuel Nodal, Henry R. Powell, Long Di, Rolando Torres, Lai Yee Leung, Andres Mariano Rubiano, Ross M.… Read More...