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A Computational Model Integrating Multiple Phenomena on Cued Fear Conditioning, Extinction, and…
Conditioning, extinction, and reinstatement are fundamental learning processes of animal adaptation, also strongly involved in human pathologies such as post-traumatic stress disorder, anxiety, depression, and dependencies. Cued fear…
PET Imaging for Dynamically Monitoring Neuroinflammation in APP/PS1 Mouse Model Using [18F]DPA714
Background: In the pathogenesis of Alzheimer's disease (AD), microglia play an increasingly important role. Molecular imaging of neuroinflammatory targeting microglia activation and the high expression of 18-kDa translocator protein (TSPO)…
Effective and Accurate Diagnosis of Subjective Cognitive Decline Based on Functional Connection and…
Subjective cognitive decline (SCD) is considered the earliest preclinical stage of Alzheimer’s disease (AD) that precedes mild cognitive impairment (MCI). Effective and accurate diagnosis of SCD is crucial for early detection of and timely…
Proteomics for Studying the Effects of Ketogenic Diet Against Lithium Chloride/Pilocarpine Induced…
The ketogenic diet (KD) demonstrates antiepileptogenic and neuroprotective efficacy, but the precise mechanisms are unclear. Here we explored the mechanism through systematic proteomics analysis of the lithium chloride-pilocarpine rat…
Effects of Akt/mTOR/p70S6K Signaling Pathway Regulation on Neuron Remodeling Caused by Translocation…
Peripheral nerve injury repair has been considered a difficult problem in the field of trauma for a long time. Conventional surgical methods are not applicable in some special types of nerve injury, prompting scholars to seek to develop…
Serum Neurofilament Levels in Children With Febrile Seizures and in Controls
ObjectiveNeuroaxonal damage is reflected by serum neurofilament light chain (sNfL) values in a variety of acute and degenerative diseases of the brain. The aim of this study was to investigate the impact of febrile and epileptic seizures on…
Perspective: Phase Amplitude Coupling–Based Phase–Dependent Neuromodulation in Parkinson’s Disease
Deep brain stimulation (DBS) is an effective surgical therapy for Parkinson’s disease (PD). However, limitations of the DBS systems have led to great interest in adaptive neuromodulation systems that can dynamically adjust stimulation…
White Matter Microstructure Changes and Cognitive Impairment in the Progression of Chronic Kidney…
BackgroundCognitive impairment is a well-defined complication of chronic kidney disease (CKD), but the neural mechanisms are largely unknown.ObjectivesThe study aimed to assess white matter (WM) microstructure changes and their relationship…
Diurnal Variation Induces Neurobehavioral and Neuropathological Differences in a Rat Model of…
Traumatic brain injury (TBI) induces two types of brain damage: primary and secondary. Damage initiates a series of pathophysiological processes, such as metabolic crisis, excitotoxicity with oxidative stress-induced damage, and…