Determinants of perioperative transfusion risk in patients with adult spinal deformity

Journal of Neurosurgery: Spine, Ahead of Print.
OBJECTIVETo determine predictors of perioperative allogeneic packed red blood cell (pRBC) transfusion requirement (total units transfused) in patients with adult spinal deformity (ASD).METHODSThe authors retrospectively analyzed records of patients aged 18 years or older who underwent surgical correction of ASD that involved 4 or more spinal levels by the same spine surgeon between 2010 and 2016.… Read More...

Diffusion tensor imaging and ventricle volume quantification in patients with chronic shunt-treated hydrocephalus: a matched case-control study

Journal of Neurosurgery, Ahead of Print.
OBJECTIVEThe object of this study was to use diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) to characterize the long-term effects of hydrocephalus and shunting on white matter integrity and to investigate the relationship of ventricular size and alterations in white matter integrity with headache and quality-of-life outcome measures.METHODSPatients with shunt-treated hydrocephalus and age- and sex-matched healthy controls were recruited into the study and underwent anatomical and DTI imaging on a 3-T MRI scanner.… Read More...

The natural history of complete spinal cord injury: a pooled analysis of 1162 patients and a meta-analysis of modern data

Journal of Neurosurgery: Spine, Ahead of Print.
OBJECTIVEThe natural history of complete spinal cord injury (SCI) is poorly studied. The classically quoted rate of improvement or conversion for patients with American Spinal Injury Association (ASIA) grade A (ASIA A) injuries is 15%–20%; however, data supporting this rate are very limited.… Read More...

Motor network recovery in patients with chronic spinal cord compression: a longitudinal study following decompression surgery

Journal of Neurosurgery: Spine, Ahead of Print.
OBJECTIVEThe authors used functional MRI to assess cortical reorganization of the motor network after chronic spinal cord compression and to characterize the plasticity that occurs following surgical intervention.METHODSA 3-T MRI scanner was used to acquire functional images of the brain in 22 patients with reversible cervical spinal cord compression and 10 control subjects.… Read More...

Geographic proximity to specialized pediatric neurosurgical care in the contiguous United States

Journal of Neurosurgery: Pediatrics, Ahead of Print.
OBJECTIVEAbsent from an analysis of supply is consideration of the geographic distribution of pediatric neurosurgeons. Several patient socioeconomic metrics are known to be associated with outcome in pediatric neurosurgical diseases, such as hydrocephalus. The purpose of this study was to determine current geographic proximity to pediatric neurosurgical care using professional society databases.… Read More...

Clip ligation for ruptured intracranial aneurysm in a child with Loeys-Dietz syndrome: case report

Journal of Neurosurgery: Pediatrics, Ahead of Print.
The authors present the case of a pediatric patient with Loeys-Dietz syndrome (LDS) who underwent craniotomy for clip ligation of a ruptured intracranial aneurysm. To the authors’ knowledge, this is the youngest reported patient with LDS who has been treated for a ruptured intracranial aneurysm.… Read More...

Enhancement of antitumor activity by using 5-ALA–mediated sonodynamic therapy to induce apoptosis in malignant gliomas: significance of high-intensity focused ultrasound on 5-ALA-SDT in a mouse glioma model

Journal of Neurosurgery, Ahead of Print.
OBJECTIVEHigh invasiveness of malignant gliomas frequently causes early local recurrence of the tumor, resulting in extremely poor outcome. To control such recurrence, novel therapies targeted toward infiltrating glioma cells around the tumor border are required.… Read More...

Human genetics and molecular mechanisms of vein of Galen malformation

Journal of Neurosurgery: Pediatrics, Ahead of Print.
Vein of Galen malformations (VOGMs) are rare developmental cerebrovascular lesions characterized by fistulas between the choroidal circulation and the median prosencephalic vein. Although the treatment of VOGMs has greatly benefited from advances in endovascular therapy, including technical innovation in interventional neuroradiology, many patients are recalcitrant to procedural intervention or lack accessibility to specialized care centers, highlighting the need for improved screening, diagnostics, and therapeutics.… Read More...

Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

Journal of Neurosurgery, Ahead of Print.
OBJECTIVEThe authors conducted a study to test if the cortical brain tissue levels of soluble amyloid beta (Aβ) reflect the propensity of cortical Aβ aggregate formation and may be an additional factor predicting surgical outcome following idiopathic normal pressure hydrocephalus (iNPH) treatment.METHODSHighly selective ELISAs (enzyme-linked immunosorbent assays) were used to quantify soluble Aβ40, Aβ42, and neurotoxic Aβ oligomers/protofibrils, associated with Aβ aggregation, in cortical biopsy samples obtained in patients with iNPH (n = 20), sampled during ventriculoperitoneal (VP) shunt surgery.… Read More...