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Levodopa‐Induced Dyskinesia Are Mediated by Cortical Gamma Oscillations in Experimental Parkinsonism
Christopher Güttler,
Jennifer Altschüler,
Kaloyan Tanev,
Saskia Böckmann,
Jens Kersten Haumesser,
Vadim V. Nikulin,
Andrea A. Kühn,
Christoph Riesen
0
ABSTRACT
Background
Levodopa is the most efficacious drug in the symptomatic therapy of motor symptoms in Parkinson's disease (PD); however, long‐term treatment is often complicated by troublesome levodopa‐induced dyskinesia (LID). Recent…
Proenkephalin Decreases in Cerebrospinal Fluid with Symptom Progression of Huntington’s…
Valter Niemela,
Anne‐Marie Landtblom,
Dag Nyholm,
Maria Kneider,
Radu Constantinescu,
Martin Paucar,
Per Svenningsson,
Sandy Abujrais,
Joachim Burman,
Ganna Shevchenko,
Jonas Bergquist,
Jimmy Sundblom
0
ABSTRACT
Objective
Identifying molecular changes that contribute to the onset and progression of Huntington's disease (HD) is of importance for the development and evaluation of potential therapies.
Methods
We conducted an unbiased…
Efficacy and safety of tipepidine as adjunctive therapy in major depressive disorder: a randomized,…
Saba Hoobehfekr,
Hossein Sanjari Moghaddam,
Mohammadreza Shalbafan,
Maryam Ghazizadeh Hashemi,
Mohammad Mehdi Pirmoradi,
Amirhossein Sakenian,
Amirhossein Poopak,
Shayan Kashefinejad,
Masoomeh Yarahmadi,
Shahin Akhondzadeh
0
Abstract
Aim
Tipepidine, a synthetic, non‐opioid expectorant, has been shown to improve depressive‐like behavior in animal models of depression. In this study, we assessed the efficacy and tolerability of tipepidine combination therapy…
Oleanolic acid ameliorates intestinal alterations associated with EAE
Beatriz Gutierrez, Isabel Gallardo, Lorena Ruiz, Yolanda Alvarez, Victoria Cachofeiro, Abelardo Margolles, Marita Hernandez and Maria Luisa Nieto
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Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease affecting the CNS. Recent studies have indicated that intestinal alterations play key pathogenic roles in the development of autoimmune dis...
Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a…
Mariana Mota, Vanessa Porrini, Edoardo Parrella, Marina Benarese, Arianna Bellucci, Sina Rhein, Markus Schwaninger and Marina Pizzi
0
Activation of NF-kappaB RelA deacetylated at the lysine residues, except the lysine 310, drives pro-apoptotic transcription in noxious brain ischemia. We showed that the sinergistic combination of the histone ...
CCL3 contributes to secondary damage after spinal cord injury
Secondary damage after spinal cord injury (SCI) is characterized by a cascade of events including hemorrhage, apoptosis, oxidative stress, and inflammation which increase the lesion size which can influence th...
Immunological classification of gliomas based on immunogenomic profiling
Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking.
An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in…
Rabah Dabouz, Colin W. H. Cheng, Pénélope Abram, Samy Omri, Gael Cagnone, Khushnouma Virah Sawmy, Jean-Sébastien Joyal, Michel Desjarlais, David Olson, Alexander G. Weil, William Lubell, José Carlos Rivera and Sylvain Chemtob
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Inflammation and particularly interleukin-1β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegene...
Headache complexity (number of symptom features) differentiates post-traumatic from non-traumatic…
Cephalalgia, Ahead of Print. BackgroundPost-traumatic headaches are a common sequela of mild traumatic brain injury (concussion). It is unclear whether or how these headaches differ phenotypically from primary headaches.ObjectiveDetermine…