admin August 22, 2019

Histone deacetylase inhibitors (HDACi) are a promising therapeutic intervention for stroke. The involvement of the anti-inflammatory effects of HDACi in their neuroprotection has been reported, but the underlying mechanisms remain uncertain. Because post-stroke inflammation is a time-dependent process starting with acute and intense inflammation and followed by prolonged and mild inflammation, we proposed whether targeting the early inflammatory response could achieve the neuroprotection of HDACi.… Read More...

admin August 22, 2019

Background: Functional upper extremity (UE) motion enables humans to execute activities of daily living (ADLs). There currently exists no universal language to systematically characterize this type of motion or its fundamental building blocks, called primitives. Without a standardized classification approach, pooling mechanistic knowledge and unpacking rehabilitation content will remain challenging.… Read More...

admin August 22, 2019

Background: In contrast to many neuroimaging modalities, clinical interpretation of EEG does not take advantage of post-processing and digital signal analysis. In most centers, EEG is still interpreted at sensor level, exactly as half a century ago. A major task in clinical EEG interpretation is the identification of interictal epileptiform discharges (IEDs).… Read More...

admin August 22, 2019

PLA2G6 has been certified as a causative gene in patients with autosomal recessive early-onset Parkinson’s disease (EOPD). We reported an EOPD case caused by PLA2G6 gene mutation, and performed neurological examination, genetic analysis and multimodal neuroimaging to describe this phenotype. A compound heterozygous mutation c.991GT/c.1472+1GA was detected in this patient.… Read More...

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