admin July 19, 2018

Abstract

Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain’s immune system recognizes and controls viral infections propagating across synaptically linked neuronal circuits have remained unclear.… Read More...

Xiang Nie, Shiho Kitaoka, Kohei Tanaka, Eri Segi-Nishida, Yuki Imoto, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Masayuki Taniguchi, Yuko Mimori-Kiyosue, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashiki July 19, 2018

Nie et al. identify TLR2/4 as crucial mediators of repeated stress-induced microglial activation in the mPFC, which leads to neuronal and behavioral changes through inflammation-related cytokines. These results highlight pivotal roles of innate immunity in the mPFC in repeated stress.

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Lucas Cheadle, Christopher P. Tzeng, Brian T. Kalish, David A. Harmin, Samuel Rivera, Emi Ling, M. Aurel Nagy, Sinisa Hrvatin, Linda Hu, Hume Stroud, Linda C. Burkly, Chinfei Chen, Michael E. Greenberg July 19, 2018

Visual experience promotes the synaptic refinement of the retinogeniculate circuit by inducing the expression of the cytokine receptor Fn14 in excitatory neurons of the dorsal lateral geniculate nucleus of the thalamus.

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Qingjian Han, Di Liu, Marino Convertino, Zilong Wang, Changyu Jiang, Yong Ho Kim, Xin Luo, Xin Zhang, Andrea Nackley, Nikolay V. Dokholyan, Ru-Rong Ji July 19, 2018

How extracellular miRNA signals is unclear. Han et al. describe that miRNA-711, secreted from inoculated lymphoma cells on the back skin, binds TRPA1 ion channels extracellularly on pruriceptive neurons to drive acute and chronic itch via specific core sequence.

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