Monthly Archives

September 2024

Traumatic brain injury
Distinguishing Mild Neurocognitive Disorder Due to TBI in DSM-5 from the Controversial Post-Concussion Syndrome

by Ioannis Mavroudis September 15, 2024

by Ioannis Mavroudis September 15, 2024

The DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) includes criteria for Mild …

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Brain & Crime
Debunking the Myth: Epilepsy and the Misconception of Criminality

by Ioannis Mavroudis September 15, 2024

by Ioannis Mavroudis September 15, 2024

Epilepsy has long been a subject of fascination and misconception throughout history, often intertwined with …

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Brain & Crime
Phillip Adams and the Tragic Impact of CTE: Understanding the Role of Brain Injury in Violent Behavior

by Ioannis Mavroudis September 15, 2024

by Ioannis Mavroudis September 15, 2024

The case of Phillip Adams, a former NFL player who committed a mass murder in …

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Brain & Crime
The Moors Murders: A Chilling Crime and the Neurobiological Profile of Its Perpetrators

by Ioannis Mavroudis September 14, 2024

by Ioannis Mavroudis September 14, 2024

The Moors Murders: A Dark Chapter in British History The Moors Murders remain one of …

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Brain & Crime
Neurobiological Insights into the Mind of a Cold-Blooded Criminal: A Detailed Brain Analysis

by Ioannis Mavroudis September 14, 2024

by Ioannis Mavroudis September 14, 2024

One of the most horrific crimes in the history of Greece. For the way it …

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Traumatic brain injury
Is Post-Concussion Syndrome a Functional Disorder?

by Ioannis Mavroudis September 14, 2024

by Ioannis Mavroudis September 14, 2024

Post-Concussion Syndrome (PCS) is a complex and often misunderstood condition that can arise after a …

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Traumatic brain injury
The Role of Neuroimaging and Machine Learning in Understanding Mild Traumatic Brain Injury (mTBI)

by Ioannis Mavroudis September 13, 2024

by Ioannis Mavroudis September 13, 2024

Mild traumatic brain injury (mTBI), commonly referred to as a concussion, is one of the …

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Traumatic brain injury
Understanding Markov Blankets and Their Role in Brain Function and Injury

by Ioannis Mavroudis September 13, 2024

by Ioannis Mavroudis September 13, 2024

The brain is an incredibly complex system, constantly interacting with both internal processes and external …

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Traumatic brain injury
Caffeine and Concussion Recovery: Benefits, Drawbacks, and Recommendations

by Ioannis Mavroudis September 9, 2024

by Ioannis Mavroudis September 9, 2024

Caffeine appears to have a complex relationship with concussion recovery and post-concussion syndrome (PCS). Based …

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Traumatic brain injury
Cognitive Recovery After Traumatic Brain Injury: New Approaches for Asthenia Treatment

by myneuronews September 9, 2024

by myneuronews September 9, 2024

Traumatic brain injury (TBI) frequently results in cognitive impairments and asthenia (chronic fatigue), which can …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]