Monthly Archives

June 2025

Traumatic brain injury
Regional and Global Changes in Brain Structure 1-Year Post Pediatric “Mild” Traumatic Brain Injury

by myneuronews June 6, 2025

by myneuronews June 6, 2025

Study Overview The research investigates the long-term effects of mild traumatic brain injury (mTBI) in …

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Traumatic brain injury
The effect of recent concussion history on dynamic visual acuity and balance control in varsity athletes

by myneuronews June 6, 2025

by myneuronews June 6, 2025

Study Overview The research conducted aimed to investigate the impact of a recent history of …

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Traumatic brain injury
The Essential Role of Immunomodulatory Tregs in Visual Deficits After Military-Relevant Trauma

by myneuronews June 6, 2025

by myneuronews June 6, 2025

Immunomodulatory Mechanisms of Tregs Regulatory T cells (Tregs) play a crucial role in maintaining immune …

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Traumatic brain injury
Widespread and cell-type-specific transcriptomic reorganization following mild traumatic brain injury

by myneuronews June 6, 2025

by myneuronews June 6, 2025

Transcriptomic Changes Induced by Injury Mild traumatic brain injury (mTBI) triggers significant changes in the …

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Traumatic brain injury
Efficacy of tranexamic acid in adult isolated traumatic brain injury: A multicenter retrospective study

by myneuronews June 6, 2025

by myneuronews June 6, 2025

Efficacy of Tranexamic Acid Tranexamic acid (TXA) is an antifibrinolytic agent primarily used to reduce …

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Neuroinflammatory conditions
NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis

by myneuronews June 6, 2025

by myneuronews June 6, 2025

NEK2 Function in B Cells B cells play a crucial role in the immune system, …

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Functional neurological disorders
Detection of chronic wasting disease prions in soil at an illegal white-tailed deer carcass disposal site

by myneuronews June 6, 2025

by myneuronews June 6, 2025

Identification of CWD Prions in Soil Chronic wasting disease (CWD) is a contagious neurological disease …

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Functional neurological disorders
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

by myneuronews June 5, 2025

by myneuronews June 5, 2025

Development of Humanized Antibodies The study focuses on the creation of humanized antibodies targeting the …

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Functional neurological disorders
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

by myneuronews June 5, 2025

by myneuronews June 5, 2025

Background on TRPM4 Channel The TRPM4 channel, a member of the transient receptor potential (TRP) …

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Functional neurological disorders
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

by myneuronews June 5, 2025

by myneuronews June 5, 2025

Humanized Antibody Development The creation of humanized antibodies involves a sophisticated process that aims to …

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Exo70 Protects Against Memory and Synaptic Impairments Following Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI), a leading cause of disability in young adults, often results from external forces that damage the brain. Cellularly, mTBI induces oxidative stress, characterized by excessive reactive oxygen species (ROS) and diminished antioxidant capacity. This redox imbalance disrupts hippocampal glutamatergic transmission and synaptic plasticity, where NMDA receptors (NMDARs) are crucial. The […]
Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We systematically searched five databases for studies examining cognitive function in patients with […]
The Diagnostic and Prognostic Role of Biomarkers in Mild Traumatic Brain Injury: An Umbrella Meta-Analysis
CONCLUSIONS: The findings underscore the clinical promise of fluid biomarkers in the management of mTBI. S100B and GFAP are particularly valuable as screening and confirmatory markers, respectively. Nonetheless, further standardization of biomarker thresholds and additional longitudinal studies are necessary to validate the roles of UCH-L1, NfL, and Tau protein. The integration of these biomarkers into […]
Mechanisms Underlying Hyperexcitability: Combining Mossy Fiber Sprouting and Mossy Cell Loss in Neural Network Model of the Dentate Gyrus
Background/Objectives: A concussive head injury increases the likelihood of temporal lobe epilepsy through mechanisms that are not entirely understood. This study aimed to investigate how two key histopathological features shared by both TLE (temporal lobe epilepsy) and head injury-mossy fiber sprouting and hilar excitatory cell loss-contribute to the modulation of dentate gyrus excitability. Methods: A […]
Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury
CONCLUSIONS: Common therapeutic processes, such as focusing on sensitization, might be helpful for these conditions. As for causal mechanisms related to sensitization in the causality of psychological injuries, the major ones hypothesized relate to the biopsychosocial model, psychological control, and activation-inhibition coordination.