Monthly Archives

June 2025

Traumatic brain injury
A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protocol for a Pilot Randomized Controlled Trial

by myneuronews June 23, 2025

by myneuronews June 23, 2025

Study Overview The upcoming pilot randomized controlled trial aims to evaluate the effectiveness of a …

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Headaches
The prevalence and predictive factors of overlapping disorders of gut-brain interaction and celiac disease in children

by myneuronews June 22, 2025

by myneuronews June 22, 2025

Study Overview This investigation aims to explore the relationship between overlapping disorders of gut-brain interaction …

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Dementia
Stem Cell-Derived, Fully Differentiated Islets for Type 1 Diabetes

by myneuronews June 22, 2025

by myneuronews June 22, 2025

Background and Rationale The advancement of regenerative medicine has brought to the forefront the potential …

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Traumatic brain injury
Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury

by myneuronews June 22, 2025

by myneuronews June 22, 2025

Injury-Specific Proteomic Signatures In recent research, a growing body of evidence has revealed that distinct …

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Functional neurological disorders
Dynamic electro-clinical features in Guanidinoacetate N-methyltransferase deficiency: A familial case series

by myneuronews June 21, 2025

by myneuronews June 21, 2025

Clinical Presentation and Genetic Findings The study highlights the varied clinical presentations associated with Guanidinoacetate …

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Functional neurological disorders
Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relationship between physical frailty and neuropsychiatric disorders

by myneuronews June 21, 2025

by myneuronews June 21, 2025

Genetic Mechanisms and Neuropsychiatric Disorders Recent research has begun to unravel the complex genetic underpinnings …

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Functional neurological disorders
Dynamic electro-clinical features in Guanidinoacetate N-methyltransferase deficiency: A familial case series

by myneuronews June 21, 2025

by myneuronews June 21, 2025

Clinical Presentation and Symptoms Patients with Guanidinoacetate N-methyltransferase (GAMT) deficiency often exhibit a complex array …

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Functional neurological disorders
Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relation between physical frailty and neuropsychiatric disorders

by myneuronews June 21, 2025

by myneuronews June 21, 2025

Genetic Mechanisms in Physical Frailty Recent research has highlighted the role of genetic mechanisms in …

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Traumatic brain injury
Characterising Postural Orthostatic Tachycardia Syndrome (POTS) triggered by a viral illness compared to concussion or trauma

by myneuronews June 21, 2025

by myneuronews June 21, 2025

Understanding POTS and Its Triggers Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia …

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Functional neurological disorders
Cation-Site Disordered Cu3PdN Nanoparticles for Hydrogen Evolution Electrocatalysis

by myneuronews June 20, 2025

by myneuronews June 20, 2025

Cation-Site Disorder in Cu3PdN Nanoparticles The Cu3PdN nanoparticles exhibit a notable feature known as cation-site …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]