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"Insights into mTBI, PCS, and FND — One Synapse at a Time" A bit more creative, nodding to neuroscience roots while covering your full range.
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Ioannis Mavroudis

Ioannis Mavroudis

  • Patient educationTraumatic brain injury

    Mild Traumatic Brain Injury vs. Concussion: What’s the Difference?

    by Ioannis Mavroudis April 29, 2025
    by Ioannis Mavroudis April 29, 2025

    Mild traumatic brain injury (mTBI) is a form of brain injury that results from an …

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  • Medical professionalsTraumatic brain injury

    Recognising subtle signs of post concussion syndrome

    by Ioannis Mavroudis April 29, 2025
    by Ioannis Mavroudis April 29, 2025

    Post concussion syndrome often manifests through subtle but persistent symptoms that are easy to overlook …

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  • Brain & Crime

    The role of the frontal lobe in criminal decision making

    by Ioannis Mavroudis April 29, 2025
    by Ioannis Mavroudis April 29, 2025

    Abnormalities in the frontal lobe have been increasingly linked to criminal behaviours, particularly those involving …

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  • Functional neurological disorders

    Living with FND and maintaining quality of life

    by Ioannis Mavroudis April 29, 2025
    by Ioannis Mavroudis April 29, 2025

    Functional Neurological Disorder (FND) causes real, often debilitating neurological symptoms without detectable structural brain damage. …

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  • Brain & Art

    The connection between sculpture and spatial awareness

    by Ioannis Mavroudis April 28, 2025
    by Ioannis Mavroudis April 28, 2025

    Understanding spatial perception in three dimensions Historical interplay between sculpture and space Techniques sculptors use …

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  • Neuroscience

    Bayesian brain theories and their link to quantum mechanics

    by Ioannis Mavroudis April 28, 2025
    by Ioannis Mavroudis April 28, 2025

    The Bayesian brain hypothesis frames the brain as a probabilistic machine, constantly updating predictions based …

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  • Medical professionalsTraumatic brain injury

    Latest guidelines for mild traumatic brain injury assessment

    by Ioannis Mavroudis April 28, 2025
    by Ioannis Mavroudis April 28, 2025

    Mild traumatic brain injury, commonly known as concussion, involves subtle yet significant disruptions to brain …

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  • Patient educationTraumatic brain injury

    Post-Concussion Syndrome: A Hidden Consequence of Mild Traumatic Brain Injury

    by Ioannis Mavroudis April 28, 2025
    by Ioannis Mavroudis April 28, 2025

    Mild traumatic brain injury (mTBI) occurs when a sudden blow or jolt to the head …

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  • Brain & Crime

    Neurological disorders and their link to criminal acts

    by Ioannis Mavroudis April 28, 2025
    by Ioannis Mavroudis April 28, 2025

    Neurological disorders can profoundly alter judgement, impulse control, and emotional regulation, contributing to behaviours that …

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  • Functional neurological disorders

    The role of psychotherapy in managing FND

    by Ioannis Mavroudis April 28, 2025
    by Ioannis Mavroudis April 28, 2025

    Functional neurological disorder (FND) is a condition where neurological symptoms arise from functional, rather than …

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  • Sildenafil provokes headache but not migraine in men with migraine without aura: a randomized, placebo-controlled crossover trial
    Study Overview The research aimed to investigate the effects of sildenafil, a phosphodiesterase type 5…
  • Associations of Lifetime Cumulative Estrogen Exposure with Lifecourse Social Exposures, Cognitive Decline, and Dementia Risk Among Postmenopausal White, Black, and Latina Women
    Lifetime Estrogen Exposure and Cognitive Health Lifetime estrogen exposure has emerged as a significant factor…
  • Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
    Incretin Mimetics Mechanism of Action Incretin mimetics are agents that are designed to mimic the…
  • N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
    Study Overview This investigation focuses on the effects of N-stearidonoylethanolamine (NSE) in addressing synaptic deficits…
  • Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
    Study Overview This study investigates the long-term effects of persistent post-concussion symptoms (PPCS) on various…

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Research

  • Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
    Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
  • N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
    Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
  • Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
    CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
  • Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
    CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
  • Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
    Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]

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