Movement Disorders

Roderick P.P.W.M. Maas, Rick C.G. Helmich, Bart P.C. Warrenburg December 11, 2019

Abstract

Over the last three decades, measuring and modulating cerebellar activity and its connectivity with other brain regions has become an emerging research topic in clinical neuroscience. The most important connection is the cerebellothalamocortical pathway, which can be functionally interrogated using a paired‐pulse transcranial magnetic stimulation paradigm.… Read More...

Marisa Cressatti, Lamin Juwara, Julia M. Galindez, Ana M. Velly, Eva S. Nkurunziza, Sara Marier, Olivia Canie, Mervyn Gornistky, Hyman M. Schipper December 5, 2019

Abstract

Background

Parkinson’s disease (PD) is the most common movement disorder among adults, affecting 2% of the world population older than 65 years of age. No diagnostic biomarker for routine use in clinical settings currently exists. Dysregulation of microRNAs (miRNAs) has been implicated in various neurodegenerative conditions, including PD.… Read More...

Mariana H.G. Monje, Javier Blesa, Miguel Ángel García‐Cabezas, José A. Obeso, Carmen Cavada December 5, 2019

Abstract

Background

Dopamine loss beyond the mesostriatal system might be relevant in pathogenic mechanisms and some clinical manifestations in PD. The primate thalamus is densely and heterogeneously innervated with dopaminergic axons, most of which express the dopamine transporter, as does the nigrostriatal system.… Read More...

Stylianos Ravanidis, Anastasia Bougea, Nikolaos Papagiannakis, Matina Maniati, Christos Koros, Athina‐Maria Simitsi, Maria Bozi, Ioanna Pachi, Maria Stamelou, George P. Paraskevas, Elisabeth Kapaki, Marina Moraitou, Helen Michelakakis, Leonidas Stefanis, Epaminondas Doxakis December 4, 2019

Abstract

Background

A minimally invasive test for early detection and monitoring of Parkinson’s disease (PD) is a highly unmet need for drug development and planning of patient care. Blood plasma represents an attractive source of biomarkers. MicroRNAs (miRNAs) are conserved noncoding RNA molecules that serve as posttranscriptional regulators of gene expression.… Read More...

Maria Ana Neves, Raquel Bouça‐Machado, Daniela Guerreiro, Verónica Caniça, Filipa Pona‐Ferreira, Joaquim J. Ferreira December 4, 2019

Abstract

Background

A recent survey reported a high risk of drowning in Parkinson’s disease (PD) patients. This study intended to assess PD patients’ swimming ability and explore the disease‐related characteristics that may affect this.

Methods

A cross‐sectional study was conducted in idiopathic PD patients.… Read More...

Carola Cosentino, Marco Baccini, Martina Putzolu, Diego Ristori, Laura Avanzino, Elisa Pelosin December 4, 2019

Abstract

Freezing of gait is considered one of the most disabling gait disorders in patients with PD. An effective treatment for freezing of gait is missing, thus current management requires a multidisciplinary approach. Among treatment options, physiotherapy is acknowledged to be crucial; however, a systematic review that demonstrates its efficacy is missing.… Read More...

Grisel Lopez, Alta Steward, Emory Ryan, Catherine Groden, Edythe Wiggs, Laura Segalà, Gianina M. Monestime, Nahid Tayebi, Ellen Sidransky December 1, 2019

Abstract

Background

Although the association between mutations in GBA1 and parkinsonism is well established, most GBA1 mutation carriers never develop parkinsonism, implicating the contribution of other genetic, epigenetic, and/or environmental modifiers.

Objectives

To identify factors predisposing to or offering protection from parkinsonism among siblings with Gaucher’s disease) discordant for Parkinson disease (PD).… Read More...

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