Movement Disorders

Fadi Assaf, Yitzhak Schiller December 11, 2018

ABSTRACT

Background

PD is a common neurodegenerative disease primarily affecting the cortico–basal ganglia loop.

Objective

To investigate whether chemogenetic‐mediated neuromodulation of various nuclei and pathways can counterbalance basal ganglia network abnormalities and improve motor disability in experimental PD.

Methods

Experimental PD was induced by stereotactic injection of 6‐OHDA to the medial forebrain bundle.… Read More...

Nina Homayoon, Lukas Pirpamer, Sebastian Franthal, Petra Katschnig‐Winter, Mariella Kögl, Stephan Seiler, Karoline Wenzel, Edith Hofer, Hannes Deutschmann, Franz Fazekas, Christian Langkammer, Stefan Ropele, Reinhold Schmidt, Petra Schwingenschuh December 11, 2018

ABSTRACT

Objective: We investigated R2* relaxation rates as a marker of iron content in the substantia nigra in patients with common tremor disorders and explored their diagnostic properties.

Methods: Mean nigral R2* rates were measured in 40 patients with tremor‐dominant Parkinson’s disease (PD), 15 with tremor in dystonia, 25 with essential tremor, and 25 healthy controls.… Read More...

Joanne Trinh, Katja Lohmann, Hauke Baumann, Alexander Balck, Max Borsche, Norbert Brüggemann, Leon Dure, Marissa Dean, Jens Volkmann, Sinem Tunc, Jannik Prasuhn, Heike Pawlack, Sophie Imhoff, Christina M. Lill, Meike Kasten, Peter Bauer, Arndt Rolfs, International Parkinson's Disease Genomics Consortium (IPDGC), Christine Klein December 11, 2018

ABSTRACT

Background: Although the genetic load is high in early‐onset Parkinson’s disease, thorough investigation of the genetic diagnostic yield has yet to be established. The objectives of this study were to assess variants in known genes for PD and other movement disorders and to find new candidates in 50 patients with early‐onset PD.… Read More...

Helena Bejr‐kasem, Javier Pagonabarraga, Saül Martínez‐Horta, Frederic Sampedro, Juan Marín‐Lahoz, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Jesús Pérez‐Pérez, M. Ángeles Botí, Antonia Campolongo, Cristina Izquierdo, Berta Pascual‐Sedano, Beatriz Gómez‐Ansón, Jaime Kulisevsky December 11, 2018

Abstract

Background

Minor hallucinations and well‐structured hallucinations are considered in the severity continuum of the psychotic spectrum associated with Parkinson’s disease. Although their chronological relationship is largely unknown, the spatial patterns of brain atrophy in these 2 forms of hallucinations partially overlap, suggesting they share similar pathophysiological processes.… Read More...

Fatma Gargouri, Cécile Gallea, Marie Mongin, Nadya Pyatigorskaya, Romain Valabregue, Claire Ewenczyk, Marie Sarazin, Lydia Yahia‐Cherif, Marie Vidailhet, Stéphane Lehéricy December 11, 2018

ABSTRACT

Background: Cognitive deficits in Parkinson’s disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1‐2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).… Read More...

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