Movement Disorders

Serena Bianchi, Stefan Fuertinger, Hailey Huddleston, Steven J. Frucht, Kristina Simonyan March 7, 2019

Abstract

Background

Task‐specific focal dystonias selectively affect movements during the production of highly learned and complex motor behaviors. Manifestation of some task‐specific focal dystonias, such as musician’s dystonia, has been associated with excessive practice and overuse, whereas the etiology of others remains largely unknown.… Read More...

Un Jung Kang, Amelia K. Boehme, Graham Fairfoul, Mohammad Shahnawaz, Thong Chi Ma, Samantha J. Hutten, Alison Green, Claudio Soto March 7, 2019

ABSTRACT

Background

PD diagnosis is based primarily on clinical criteria and can be inaccurate. Biological markers, such as α‐synuclein aggregation, that reflect ongoing pathogenic processes may increase diagnosis accuracy and allow disease progression monitoring. Though α‐synuclein aggregation assays have been published, reproducibility, standardization, and validation are key challenges for their development as clinical biomarkers.… Read More...

Yi‐Ting Hsu, Ya‐Gin Chang, Yu‐Chao Liu, Kai‐Yi Wang, Hui‐Mei Chen, Ding‐Jin Lee, Sung‐Sen Yang, Chon‐Haw Tsai, Cheng‐Chang Lien, Yijuang Chern March 7, 2019

Abstract

Background

Altered γ‐aminobutyric acid signaling is believed to disrupt the excitation/inhibition balance in the striatum, which may account for the motor symptoms of Huntington’s disease. Na‐K‐2Cl cotransporter‐1 is a key molecule that controls γ‐aminobutyric acid‐ergic signaling. However, the role of Na‐K‐2Cl cotransporter‐1 and efficacy of γ‐aminobutyric acid‐ergic transmission remain unknown in Huntington’s disease.… Read More...

Lin Zou, Yukun Song, Xiangxue Zhou, Jianping Chu, Xiaoying Tang March 1, 2019

Abstract

Background

Morphology builds Wilson’s disease’s clincal basis.

Objectives

To detect and quantify regional morphometric abnormalities, in terms of both volume and shape, in patients with Wilson’s disease.

Methods

Twenty‐seven Wilson’s disease patients and 24 healthy controls were enrolled. Specific brain structures, including the bilateral caudate, putamen, globus pallidus, thalamus, amygdala, hippocampus, red nucleus, and substantia nigra (SN), were automatically extracted from each participant’s T1‐weighted image.… Read More...

Miguel Wilken, Verónica Bruno, Malco Rossi, Lucía Ameghino, Günther Deuschl, Marcelo Merello February 21, 2019

Abstract

Background

Hand position for rest tremor evaluation in PD is not standardized. We evaluated the sensitivity and specificity of different hand positions commonly used to evaluate rest tremor.

Methods

Twenty patients with PD and rest tremor were included as cases and 20 patients with essential tremor without rest tremor as controls.… Read More...

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