Signaling pathways driving multiple sclerosis: From mechanisms to natural‑product interventions
Signaling Pathways in Multiple Sclerosis Multiple sclerosis (MS) is a complex autoimmune disease characterized by the immune system’s attack on […]
Radiofrequency and pulsed magnetic fields attenuate LPS-induced neuroinflammation and demyelination via PI3K/AKT/HIF-1alpha-mediated neurovascular protection
Therapeutic Mechanisms of Radiofrequency and Pulsed Fields The therapeutic mechanisms underlying the effects of radiofrequency (RF) and pulsed magnetic fields
Distinct remission immune architectures under rituximab and azathioprine in AQP4-IgG-positive neuromyelitis optica spectrum disorder
Study Overview The study focused on examining the distinct immune responses observed in patients with AQP4-IgG-positive neuromyelitis optica spectrum disorder
Machine learning-based identification of concomitant stroke and prognostic analysis in patients with Guillain-Barré syndrome: a retrospective study
Background and Rationale Guillain-Barré syndrome (GBS) is a rare but serious neurological disorder characterized by rapid onset muscle weakness due
First Reported Coexistence of Plasma Cell Gingivitis and Multiple Sclerosis: A Case Report
Case Presentation A 42-year-old female presented with symptoms that included persistent oral discomfort and swelling of the gingiva. The patient
Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner
Study Overview The investigation aimed to elucidate the mechanisms by which myelin antigen-specific effector CD8+ T cells contribute to the
Optimizing rare neurological disease trials: Bayesian frameworks and hierarchical models for improved efficiency in clinical trial design
Framework for Bayesian Optimization Bayesian optimization represents a powerful statistical approach that addresses the challenges of designing clinical trials for
Viral associations in multiple sclerosis: pathogenetic mechanisms and therapeutic implications
Viral Pathogens and Multiple Sclerosis Multiple sclerosis (MS) is often regarded as an autoimmune disorder where the immune system mistakenly
Clinical features and treatment response of anti-Neurofascin 155 antibody-positive neuropathy in neurological Institute of Thailand
Clinical Characteristics Patients with anti-Neurofascin 155 antibody-positive neuropathy typically present with a unique set of clinical symptoms that can vary
Retinal macrophage-like cell activation and ganglion cell layer thinning are associated with disability and MRI lesion burden in multiple sclerosis
Study Overview The research examined the link between retinal macrophage-like cell activation and the thinning of the ganglion cell layer