Tag:

Alzheimer’s disease

Dementia
Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Treatment Strategy Overview In recent years, the exploration of innovative approaches to treat Alzheimer’s disease …

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Functional neurological disorders
Apolipoprotein E (APOE) and Alzheimer’s disease risk in a Ugandan population: A pilot case-control study

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Apolipoprotein E Genotypes and Alzheimer’s Disease The study investigated the relationship between different genotypes of …

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Traumatic brain injury
Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

by myneuronews May 10, 2025

by myneuronews May 10, 2025

Pathological Tau Phosphorylation Mechanisms Tau protein is a key player in maintaining the structural integrity …

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Dementia
Unraveling sex differences in Alzheimer’s disease and related endophenotypes with brain proteomes

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Research Context The study of Alzheimer’s disease (AD) has gained considerable momentum as researchers explore …

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Traumatic brain injury
Using baseline MRI radiomic features to predict the efficacy of repetitive transcranial magnetic stimulation in Alzheimer’s patients

by myneuronews May 7, 2025

by myneuronews May 7, 2025

Study Overview This study investigates the potential of baseline MRI radiomic features to predict the …

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Traumatic brain injury
Using baseline MRI radiomic features to predict the efficacy of repetitive transcranial magnetic stimulation in Alzheimer’s patients

by myneuronews May 7, 2025

by myneuronews May 7, 2025

Study Overview This study investigates the potential of baseline MRI radiomic features to forecast the …

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Functional neurological disorders
Cholinergic degeneration in prodromal and early Parkinson’s: a link to present and future disease states

by myneuronews May 6, 2025

by myneuronews May 6, 2025

Cholinergic Pathways in Parkinson’s Disease In the context of Parkinson’s disease, understanding the role of …

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Traumatic brain injury
Collision Sports and Neurodegenerative Disease: Inclusion of Moderating Risk Factors

by myneuronews May 1, 2025

by myneuronews May 1, 2025

Impact of Collision Sports on Neurodegenerative Risk Participation in collision sports can have significant implications …

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Dementia
Association of Alzheimer’s Disease and Related Dementias (ADRD) With Days at Home Among Medicare Beneficiaries After a Heart Failure Hospitalization

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Association With Days at Home The amount of time spent at home after a hospitalization …

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Functional neurological disorders
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Microglia Replacement Strategy The study introduces an innovative approach to addressing neurological disorders through the …

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Subcutaneous Botulinum Toxin Type-A Injections for the Treatment of Central Neuropathic Pain in a Patient With Multiple Sclerosis – A Case Report
Study Overview This case report examines the application of subcutaneous injections of botulinum toxin type…
Homozygous COQ9 mutation: a new cause of potentially treatable hereditary spastic paraplegia
Study Overview The research investigates the role of homozygous mutations in the COQ9 gene as…
Trends in acute care of cerebrovascular events- a joinpoint analysis with German hospital data from 2000 to 2021
Cerebrovascular Event Trends The prevalence and incidence of cerebrovascular events, commonly known as strokes, have…
Gepants in Primary Care: A Targeted Approach to Acute and Preventive Treatment of Migraine
Gepants Mechanism of Action Gepants are a novel class of oral medications specifically designed to…
Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis
Study Overview The systematic review and meta-analysis centered on curcumin supplementation aimed to investigate its…

Quantification of the cerebral pressure-flow relationship directional sensitivity: Reliability of shorter repeated squat-stand durations
The magnitude of changes in middle cerebral artery mean blood velocity (MCAv) is attenuated when mean arterial pressure (MAP) increases compared with when MAP decreases. This directional sensitivity has been characterized using a time-corrected ratio calculated on MCAv and MAP changes induced by repeated squat-stands (RSS) at 0.05 and 0.10 Hz for 300 s (∆MCAv(T)/∆MAP(T)). […]
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury
Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global functioning. A lack of studies with clinical and biomarker data from individuals living with chronic (>1 year post-injury) TBI has precluded refinement of long-term outcome classification ontology. Multimodal data in […]
A Comparison of Quantitative Pupillometry and VOMS in Division 1 Female Soccer Players
Background and Objectives: Vision uses about half of the pathways within the brain, and these anatomical structures are susceptible to injury in concussion. Authors have suggested that subconcussive head impacts, common in soccer, may disrupt visual function. The following study aimed to explore and compare quantitative pupillometry and Vestibular Ocular Motor Screening (VOMS) in female […]
Acceptability of a Brain-Injury-Tailored Yoga and Meditation Program Among Female Patients with Concussion
Background: Although concussion symptoms often resolve within 4-6 weeks, for a minority of patients, persistent postconcussion symptoms (PPCS), such as headaches, fatigue, and mood disturbances, may continue for months or years following a head injury. Rehabilitation of this group-often female-is crucial for reducing health and gender disparities in concussion recovery. A recent report by the […]
The national football league concussion settlement race-norming incident in context
CONCLUSION: Replacing race-norms involves using performance-based estimates of preexisting skill level that are individualized and not subject to racial profiling. In research, racial/ethnic group comparisons give way to the study of measurable sociocultural dimensions on which these groupings differ that potentially impact neuropsychological test scores. To date, few such dimensions have demonstrated incremental contributions beyond […]