Tag:

biomarkers

Dementia
Metabolic changes in the one-carbon metabolism-related amino acids during etoposide-induced cellular senescence of neuronal cells

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Metabolic Alterations in Neuronal Cells Metabolic changes in neuronal cells, particularly during cellular senescence, play …

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Movement Disorders
Defense mechanisms in immune-mediated diseases: a cross-sectional study focusing on Severe Allergic Asthma and Hymenoptera Venom Anaphylaxis patients

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Study Overview The investigation aimed to explore the immune system’s response mechanisms in patients suffering …

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Traumatic brain injury
Aldehydic load as an objective imaging biomarker of mild traumatic brain injury

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Aldehydic Load Measurement The measurement of aldehydic load plays a crucial role in understanding the …

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Traumatic brain injury
Neurobiomarkers for Traumatic Brain Injury: Comparison of Serum Values Within 24 Hours of Injury With Glasgow Coma Scale (GCS) Scores in a Prospective Cohort Trial

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Neurobiomarkers in Traumatic Brain Injury Neurobiomarkers represent measurable indicators located in the body, which provide …

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Functional neurological disorders
Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Structural Characterization of LGI1-ADAM22 Complex The LGI1-ADAM22 complex plays a pivotal role in the synaptic …

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Functional neurological disorders
Development of a novel liquid chromatography-tandem mass spectrometry based enzymatic assay of 5,10-methylenetetrahydrofolate reductase

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Enzymatic Assay Development The development of a novel enzymatic assay for 5,10-methylenetetrahydrofolate reductase (MTHFR) taps …

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Traumatic brain injury
Biomarker evidence of neurodegeneration in mid-life former rugby players

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Neurodegeneration Biomarkers Biomarkers indicative of neurodegeneration are crucial for understanding the underlying processes affecting brain …

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Traumatic brain injury
Brain health concerns in former rugby players: clinical and cognitive phenotypes

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Context of Brain Health in Rugby The discussion around brain health in former rugby players …

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Traumatic brain injury
The chronic aftermath of recurrent intimate partner violence-related brain injuries: Insights from rat models of traumatic brain injury and non-fatal strangulation

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Research Framework The exploration of recurrent intimate partner violence (IPV) and its effects on brain …

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Movement Disorders
Distinct 11C-ER176 PET Neuroinflammatory Profiles and Tau Colocalization in Progressive Apraxia of Speech With and Without Parkinson-plus Syndrome

by myneuronews June 30, 2025

by myneuronews June 30, 2025

Study Overview The research focuses on the complex relationship between neuroinflammation and tau pathology in …

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Aldehydic load as an objective imaging biomarker of mild traumatic brain injury
Mild traumatic brain injury (mTBI) is neurological impairment induced by biomechanical forces without structural brain damage, currently without an objective diagnostic tool. Downstream injury stems from oxidative damage leading to the production of neurotoxic aldehydes. A collagen-based 3D corticomimetic in vitro model of concussion was developed, confirming aldehyde production following impact. Total aldehyde levels were […]
Plasma levels of biomarkers associated with vasodilation and neuroinflammation in pediatric patients with head trauma and their relationship with clinical characteristics of patients
CONCLUSION: Evaluation of pediatric patients with head trauma together with these neuropeptides may provide great benefits in deciding whether to perform radiography such as CT. However, due to the relatively low sensitivities in ROC analysis and small sample size, further studies are warranted before they may be used as a screening test to distinguish CT-positive […]
Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures
Service members and law enforcement personnel are frequently exposed to blast overpressure during training and combat due to the use of heavy weaponry such as large-caliber rifles, explosives, and ordnance. The cumulative effects of these repeated low-level (
Trajectories of fear avoidance behavior and recovery after mild traumatic brain injury: Findings from the Toronto Concussion Study
CONCLUSION: Early fear avoidance behavior often decreases, but when it does not, it is associated with worse recovery from mTBI. These findings may inform the timing and design of interventions targeting fear avoidance behavior in patients with mTBI. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Proposed Reformulation of Brain Injury Criteria (BrIC) Using Head Rotation-Induced Brain Injury Thresholds Simulated and Derived Directly from A Subhuman Primate Finite Element Model
Recent studies have found that Brain Injury Criteria (BrIC) grossly overpredicts instances of real-world, severe traumatic brain injury (TBI). However, as it stands, BrIC is the leading candidate for a rotational head kinematics-based brain injury criteria for use in automotive regulation and general safety standards. This study attempts to understand why BrIC overpredicts the likelihood […]