Tag:

blood-brain barrier

Dementia
Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD-1 mutant mice

by myneuronews November 15, 2025

by myneuronews November 15, 2025

Impact of C9orf72 Loss on Neuromuscular Systems The loss of the C9orf72 gene has been …

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Traumatic brain injury
AQP4 in cerebrospinal fluid correlates with severity and prognosis in moderate to severe traumatic brain injury

by myneuronews October 25, 2025

by myneuronews October 25, 2025

Background and Rationale Traumatic brain injury (TBI) is a significant public health concern, often resulting …

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Traumatic brain injury
Associations between traumatic brain injury and the prevalence of Alzheimer’s disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study

by myneuronews August 29, 2025

by myneuronews August 29, 2025

Associations between TBI and Alzheimer’s Disease Traumatic brain injury (TBI) has garnered significant interest as …

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Traumatic brain injury
Chronic traumatic encephalopathy

by myneuronews August 29, 2025

by myneuronews August 29, 2025

Pathophysiology of Chronic Traumatic Encephalopathy Chronic traumatic encephalopathy (CTE) is a neurodegenerative condition associated with …

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Traumatic brain injury
Triamcinolone-loaded nanocarriers: a novel strategy to mitigate cognitive and emotional sequelae induced by traumatic brain injury via modulation of oxidative stress

by myneuronews August 28, 2025

by myneuronews August 28, 2025

Study Overview This research investigates the innovative use of triamcinolone-loaded nanocarriers as a strategy to …

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Dementia
High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

by myneuronews August 22, 2025

by myneuronews August 22, 2025

Study Overview The research focused on improving the delivery of bispecific antibodies to the brain. …

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Dementia
Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association

by myneuronews August 18, 2025

by myneuronews August 18, 2025

Vascular Contributions to Cognitive Health The relationship between vascular health and cognitive function is a …

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Headaches
Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience

by myneuronews August 12, 2025

by myneuronews August 12, 2025

Clinical Characteristics Cerebral Amyloid Angiopathy-Related Inflammation (CAA-RI) manifests through a variety of clinical symptoms that …

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Functional neurological disorders
Double-edged sword effect of Sutterella in neurological disorders: implications for the gut-brain axis and neuroimmune interactions

by myneuronews July 18, 2025

by myneuronews July 18, 2025

Sutterella and its Role in Neurological Disorders Sutterella, a genus of bacteria predominantly found in …

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Functional neurological disorders
Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Luminal Glycocalyx and Its Role in Blood Brain Barrier Integrity The luminal glycocalyx is a …

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Prevalence of Traumatic Brain Injury in Detained Youth: Associations With Aggression, Violent Charges, and Behavioral Infractions
CONCLUSIONS: TBI is common among detained youth and is selectively associated with elevated physical aggression. Routine TBI screening at intake and interventions targeting impulse control and emotion regulation may improve outcomes for this high-risk population.
Gliatilin in the Treatment of Cognitive Impairments Not Reaching the Level of Dementia: Meta-Analysis and Systematic Review
CONCLUSION: The main challenge during the analysis was methodological, population, and statistical heterogeneity, which required not only the use of a random effects model but also active search and exclusion of some sources. However, despite several limitations, the internal consistency and absence of contradictions in the analysis results demonstrated the robustness of the evidence obtained. […]
Relationships between vestibular dysfunction and cognitive performance in military veterans with mild to moderate TBI
Objective: Vestibular dysfunction is common following mild-to-moderate traumatic brain injury (TBI) and impacts quality of life. However, little is known regarding the persistence and stability of vestibular symptoms over time and their effects on cognition. This study examined self-reported vestibular symptoms 1 to 2 years following mild-to-moderate TBI in a Military/Veteran cohort. We further evaluated […]
Within-Person Score Distribution Measures as Performance Validity Indicators in Service Members and Veterans with and without History of Mild Traumatic Brain Injury
CONCLUSIONS: OTBM and ABN demonstrated strong potential for use as embedded PVTs with excellent classification accuracy. CV displayed lower classification accuracy with group differences primarily due to changes in mean performance rather than increased dispersion. Further development and cross-validation of WPSD-based PVTs is warranted in civilian samples.
Development of a Fall-Specific Impact Testing Method to Evaluate Safety Helmet Performance and Injury Risk
CONCLUSIONS: Type II helmets offer substantial benefits in head protection compared to Type I models for oblique fall-related impacts. By including both skull fracture and concussion risk in the STAR score, the proposed methodology can differentiate high and low-performing safety helmets.