Tag:

blood-brain barrier

Dementia
High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

by myneuronews August 22, 2025

by myneuronews August 22, 2025

Study Overview The research focused on improving the delivery of bispecific antibodies to the brain. …

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Dementia
Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association

by myneuronews August 18, 2025

by myneuronews August 18, 2025

Vascular Contributions to Cognitive Health The relationship between vascular health and cognitive function is a …

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Headaches
Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience

by myneuronews August 12, 2025

by myneuronews August 12, 2025

Clinical Characteristics Cerebral Amyloid Angiopathy-Related Inflammation (CAA-RI) manifests through a variety of clinical symptoms that …

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Functional neurological disorders
Double-edged sword effect of Sutterella in neurological disorders: implications for the gut-brain axis and neuroimmune interactions

by myneuronews July 18, 2025

by myneuronews July 18, 2025

Sutterella and its Role in Neurological Disorders Sutterella, a genus of bacteria predominantly found in …

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Functional neurological disorders
Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Luminal Glycocalyx and Its Role in Blood Brain Barrier Integrity The luminal glycocalyx is a …

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Functional neurological disorders
Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Luminal Vascular Dysfunction as a Mechanism In examining how luminal vascular dysfunction contributes to blood-brain …

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Functional neurological disorders
Role of ALOX5AP in the pathogenesis of cerebral small vessel disease: impact of inflammation and lipid metabolism dysregulation

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Pathophysiological Mechanisms of ALOX5AP The role of ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) in the pathogenesis …

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Functional neurological disorders
Role of ALOX5AP in the pathogenesis of cerebral small vessel disease: impact of inflammation and lipid metabolism dysregulation

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Pathophysiological Mechanisms of ALOX5AP ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein) plays a pivotal role in the pathophysiology …

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Functional neurological disorders
Wogonin Inhibits Oxidative Stress in Hypoxia-Induced hCMEC/D3 Cells Through Suppressing CXCL8-Mediated TLR4/NF-κB Pathway

by myneuronews July 4, 2025

by myneuronews July 4, 2025

Mechanisms of Wogonin in Oxidative Stress Wogonin, a naturally occurring flavonoid found in various plants, …

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Headaches
The efficacy and safety of intrathecal pemetrexed for leptomeningeal metastasis from non-small cell lung cancer: a single-arm meta-analysis of Chinese patients

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Study Overview This study focuses on evaluating the effectiveness and safety of intrathecal pemetrexed in …

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Current trends and projections for potential acupuncture needs globally and in China: evidence from the Global Burden of Disease Study 2021
Global Acupuncture Needs Assessment The assessment of global acupuncture needs involves a multi-faceted approach that…
Plasma extracellular vesicles and phosphorylated tau 181 as early biomarkers of cognitive impairment in Alzheimer’s dementia
Study Overview The focus of this research is on exploring the potential of plasma extracellular…
Development and Evaluation of Upper Extremity Movement Quality Outcome Measures for Individuals with Functional Movement Disorder
Methodology for Movement Quality Assessment The study employed a comprehensive methodology for assessing upper extremity…
The Clinical Utility of a Novel Multimodal Assessment Battery for Acute Sport-Related Concussion
Assessment Framework The evaluation of acute sport-related concussions necessitates a multidimensional approach that integrates various…
Associations of Symptomatic Head Trauma/Concussion Diagnosis with Sleep-Related Outcomes in Children
Study Background The relationship between head trauma and its subsequent effects on children’s sleep patterns…

Management of the paediatric patient with acute head trauma
Acute head trauma (AHT) leading to traumatic brain injury is an important cause of paediatric morbidity and mortality. Injury severity depends on the mechanism of trauma and age of the child. The vast majority of childhood AHT cases are mild, require no therapy, and leave no long-term sequelae. However, it is important to identify individuals […]
Neuroimaging correlates of symptom burden and functional recovery following mild traumatic brain injury: A systematic review
CONCLUSIONS: Acute MRI, when contextualised with clinical data, helps delineate correlates of mTBI symptom burden and functional recovery. To strengthen inference, future neuroimaging studies should prespecify and report symptom burden and functional recovery as core endpoints.
Structural brain alterations and predictors of clinical improvement in functional cognitive disorder after concussion
Functional cognitive disorder (FCD) is an under-studied yet likely prevalent subtype of functional neurological disorder (FND), with neural mechanisms that remain poorly understood. While studies of other FND subtypes have revealed structural and functional brain alterations across several large-scale brain networks, no study to date has investigated neural alterations in FCD. Here, we examined structural […]
Long-term health outcomes of adolescent mTBI: a scoping review
CONCLUSION: This review provides insight into the potential long-term concerns of adolescent mTBI and highlights areas needing further research for more robust conclusions. The review identifies critical considerations for health professionals when assessing adolescents with mTBI and creating recovery plans to promote full recovery with limited long-term impact.
Exploring sports-related concussion awareness and response amongst teenage grassroots soccer players in the UK: a qualitative study
CONCLUSIONS: Effective SRC management requires tailored education programs to overcome barriers and promote safety within grassroots youth soccer. Addressing gender norms and enhancing education can foster a culture of support and accountability, safeguarding the well-being of young athletes. There is a need for better awareness and more precautionary behaviors among all stakeholders in grassroots soccer.