Tag:

brain function

Dementia
Cortical inhibitory and facilitatory alterations in the continuum of alpha-synucleinopathies

by myneuronews July 25, 2025

by myneuronews July 25, 2025

Cortical Inhibition in Alpha-Synucleinopathies Alterations in cortical inhibition have been observed in alpha-synucleinopathies, which include …

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Functional neurological disorders
Gut microbiota and myelination: Crosstalk across the lifespan and microbiota-based modulation strategies

by myneuronews July 25, 2025

by myneuronews July 25, 2025

Gut Microbiota’s Role in Myelination The gut microbiota, a complex community of microorganisms residing in …

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Traumatic brain injury
Microglial depletion and repopulation differentially modulate sleep and inflammation in a mouse model of traumatic brain injury

by myneuronews July 24, 2025

by myneuronews July 24, 2025

Study Overview This research investigates the complex relationship between microglial cells, sleep patterns, and inflammation …

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Functional neurological disorders
Successful Treatment of Functional Neurologic Symptom Disorder (Conversion Disorder) With Subdissociative Dose Ketamine in the Emergency Department

by myneuronews July 24, 2025

by myneuronews July 24, 2025

Treatment Overview Treatment for Functional Neurologic Symptom Disorder (FND), previously known as conversion disorder, often …

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Functional neurological disorders
Integrated Transcriptomic Analysis Provided Diagnostic and Pathophysiological Insights for Epilepsy

by myneuronews July 23, 2025

by myneuronews July 23, 2025

Integrated Transcriptomic Insights Recent advancements in transcriptomic analysis have opened new avenues for understanding the …

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Functional neurological disorders
The Frmpd3 Protein Regulates Susceptibility to Epilepsy by Combining with GRIP and GluA2

by myneuronews July 23, 2025

by myneuronews July 23, 2025

Frmpd3 Function in Epilepsy The study of the Frmpd3 protein reveals its significant role in …

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Dementia
Embracing the Modern Biochemistry of Brain Metabolism

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Understanding Brain Metabolism The brain is an extraordinarily energy-demanding organ, consuming approximately 20% of the …

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Traumatic brain injury
Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Understanding Pupillary Light Reflex The pupillary light reflex is a complex neurological response that occurs …

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Traumatic brain injury
Sex differences in temperature rhythm disruption after traumatic brain injury

by myneuronews July 19, 2025

by myneuronews July 19, 2025

Research Background The intricate relationship between brain function and body temperature regulation has long been …

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Functional neurological disorders
Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features

by myneuronews July 18, 2025

by myneuronews July 18, 2025

Cerebellar Normative Features The cerebellum, a structure located at the back of the brain, has …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]