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clinical challenges

Stroke
Dental Adhesive Protection Against Development of Noncarious Cervical Lesions

by myneuronews June 3, 2025

by myneuronews June 3, 2025

Clinical Efficacy of Dental Adhesives Dental adhesives play a crucial role in modern dentistry, serving …

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Functional neurological disorders
Aggressive and Refractory Attack of AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder Treated With Ravulizumab: A Case Report

by myneuronews May 22, 2025

by myneuronews May 22, 2025

Clinical Presentation and Diagnosis In this case report, the patient presented with symptoms characteristic of …

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Increased Risk of Myocardial Infarction in Inclusion Body Myositis: A Non-Concurrent Cohort Study

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Cardiovascular Risk Factors in Inclusion Body Myositis The relationship between inclusion body myositis (IBM) and …

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Functional neurological disorders
Distinguishing Functional Neurological Disorder from Malingering or Feigning

by Ioannis Mavroudis April 21, 2024

by Ioannis Mavroudis April 21, 2024

Functional Neurological Disorder (FND) presents a frontier of exploration in neurological and psychiatric disciplines, where …

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Exo70 Protects Against Memory and Synaptic Impairments Following Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI), a leading cause of disability in young adults, often results from external forces that damage the brain. Cellularly, mTBI induces oxidative stress, characterized by excessive reactive oxygen species (ROS) and diminished antioxidant capacity. This redox imbalance disrupts hippocampal glutamatergic transmission and synaptic plasticity, where NMDA receptors (NMDARs) are crucial. The […]
Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We systematically searched five databases for studies examining cognitive function in patients with […]
The Diagnostic and Prognostic Role of Biomarkers in Mild Traumatic Brain Injury: An Umbrella Meta-Analysis
CONCLUSIONS: The findings underscore the clinical promise of fluid biomarkers in the management of mTBI. S100B and GFAP are particularly valuable as screening and confirmatory markers, respectively. Nonetheless, further standardization of biomarker thresholds and additional longitudinal studies are necessary to validate the roles of UCH-L1, NfL, and Tau protein. The integration of these biomarkers into […]
Mechanisms Underlying Hyperexcitability: Combining Mossy Fiber Sprouting and Mossy Cell Loss in Neural Network Model of the Dentate Gyrus
Background/Objectives: A concussive head injury increases the likelihood of temporal lobe epilepsy through mechanisms that are not entirely understood. This study aimed to investigate how two key histopathological features shared by both TLE (temporal lobe epilepsy) and head injury-mossy fiber sprouting and hilar excitatory cell loss-contribute to the modulation of dentate gyrus excitability. Methods: A […]
Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury
CONCLUSIONS: Common therapeutic processes, such as focusing on sensitization, might be helpful for these conditions. As for causal mechanisms related to sensitization in the causality of psychological injuries, the major ones hypothesized relate to the biopsychosocial model, psychological control, and activation-inhibition coordination.

clinical challenges

Dental Adhesive Protection Against Development of Noncarious Cervical Lesions

Aggressive and Refractory Attack of AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder Treated With Ravulizumab: A Case Report

Increased Risk of Myocardial Infarction in Inclusion Body Myositis: A Non-Concurrent Cohort Study

Distinguishing Functional Neurological Disorder from Malingering or Feigning