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clinical signs

Medical professionals Traumatic brain injury
Recognising subtle signs of post concussion syndrome

by Ioannis Mavroudis April 29, 2025

by Ioannis Mavroudis April 29, 2025

Post concussion syndrome often manifests through subtle but persistent symptoms that are easy to overlook …

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High frequency stimulation activates hot spots of spontaneous synaptic transmission
Study Overview The research focuses on understanding the effects of high-frequency stimulation on synaptic transmission…
Increased Risk of Myocardial Infarction in Inclusion Body Myositis: A Non-Concurrent Cohort Study
Cardiovascular Risk Factors in Inclusion Body Myositis The relationship between inclusion body myositis (IBM) and…
Efficacy, safety, and tolerability of chenodeoxycholic acid (CDCA) in adult patients with cerebrotendinous xanthomatosis (RESTORE): a randomized withdrawal, double-blind, placebo-controlled, crossover phase 3 study
Efficacy of Chenodeoxycholic Acid Chenodeoxycholic acid (CDCA) has emerged as a critical therapeutic option for…
Arteriolosclerosis in CNS Tissues Outside the Cerebrum and Late-Life Motor Impairment
Arteriolosclerosis in Non-Cerebral CNS Regions Arteriolosclerosis, a condition characterized by the thickening and hardening of…
FOXG1 Improves Cognitive Function in Alzheimer’s Disease by Promoting Endogenous Neurogenesis
Impact of FOXG1 on Neurogenesis The role of FOXG1 in neurogenesis is increasingly being recognized…

Clinical Cut Point for the Pittsburgh Sleep Quality Index After Adolescent Concussion
CONCLUSION: Adolescents with a concussion demonstrated worse sleep quality than uninjured controls. The results suggest that sleep quality, as measured by the PSQI, can distinguish between adolescents with and without a concussion, using a cut point of 4.
Single-Quantum Sodium MRI at 3T for the Separation of Mono- and Bi-T2 Sodium Signals
Sodium magnetic resonance imaging (MRI) is highly sensitive to cellular ionic balance due to tenfold difference in sodium concentration across membranes, actively maintained by the sodium-potassium (Na ^(+) -K ^(+) ) pump. Disruptions in this pump or membrane integrity, as seen in neurological disorders like epilepsy, multiple sclerosis, bipolar disease, and mild traumatic brain injury, […]
Effects of Subanesthetic Intravenous Ketamine Infusion on Stress Hormones and Synaptic Density in Rats with Mild Closed-Head Injury
Background: Every year, over 40 million people sustain mild traumatic brain injury (mTBI) which affects the glucocorticoid stress pathway and synaptic plasticity. Ketamine, a multimodal dissociative anesthetic, modulates the stress pathway and synaptic plasticity. However, the effects of post-mTBI ketamine administration on plasma stress hormones and brain synaptic plasticity are largely unknown. Methods: Adult male […]
Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter loss in concussive head injury
BACKGROUND: Leukemia Inhibitory Factor (LIF) is an injury-induced cytokine that peaks 48 hours after a traumatic brain injury (TBI). Juvenile LIF haplodeficient mice exhibit desynchronized glial responses, increased neurodegeneration, decreased axonal conductivity and behavioral deficits after a concussive head injury. Given the necessity of LIF during the acute recovery phase after injury, we hypothesized that […]
Role of anxiety in exercise intolerance and autonomic nervous system dysfunction post-concussion
CONCLUSIONS: Adults with pre-existing and post-injury anxiety experienced altered physiological responses to exercise post-concussion and completed fewer stages of the BCBT. Anxiety should be considered by clinicians when interpreting findings from exercise intolerance tests such as the BCBT.

clinical signs

Recognising subtle signs of post concussion syndrome