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cognitive impairment

Functional neurological disorders
Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum

by myneuronews April 24, 2025

by myneuronews April 24, 2025

Aβ Plaque Polymorphism Overview Amyloid-beta (Aβ) plaques are characteristic features found in the brains of …

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Functional neurological disorders
Five functional domains associated with gait performance in Parkinson’s disease and lateral trunk flexion

by myneuronews April 23, 2025

by myneuronews April 23, 2025

Functional domains influencing gait performance Gait performance in individuals with Parkinson’s disease (PD) is a …

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Cognitive impairment Traumatic brain injury
Cognition After Traumatic Brain Injury: Rethinking Recovery, Complexity, and Hope

by Ioannis Mavroudis April 13, 2025

by Ioannis Mavroudis April 13, 2025

Today, we’re delving into a topic that touches millions of lives but is still too …

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Chronic Traumatic Encephalopathy Traumatic brain injury
Exploring the Complex Impact of Repeated Head Trauma in Contact Sports: Beyond CTE

by Ioannis Mavroudis November 6, 2024

by Ioannis Mavroudis November 6, 2024

The connection between repeated head trauma and long-term health issues has gained significant attention in …

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Traumatic brain injury
The Role of the IMPACT Test in Concussion Screening and Treatment Planning

by Ioannis Mavroudis September 28, 2024

by Ioannis Mavroudis September 28, 2024

Mild Traumatic Brain Injury (mTBI), commonly referred to as a concussion, has been a growing …

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Traumatic brain injury
Brain Fog: Understanding the Phenomenon and its Impact on Cognitive Function

by Ioannis Mavroudis September 23, 2024

by Ioannis Mavroudis September 23, 2024

Brain fog is a non-medical term often used to describe a collection of cognitive impairments, …

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Traumatic brain injury
Understanding Markov Blankets and Their Role in Brain Function and Injury

by Ioannis Mavroudis September 13, 2024

by Ioannis Mavroudis September 13, 2024

The brain is an incredibly complex system, constantly interacting with both internal processes and external …

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Cognitive impairment Traumatic brain injury
Risk Factors for Functional Cognitive Impairment after Mild Traumatic Brain Injury

by Ioannis Mavroudis April 24, 2024

by Ioannis Mavroudis April 24, 2024

Mild traumatic brain injury (mTBI) poses a risk of long-term functional cognitive impairment (CI), influenced …

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Cognitive impairment Medical professionals Traumatic brain injury
Chronic Cognitive Impairment Following Traumatic Brain Injury: A Closer Look

by Ioannis Mavroudis March 9, 2024

by Ioannis Mavroudis March 9, 2024

This article provides a comprehensive analysis of the multifaceted impacts of traumatic brain injury (TBI), …

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Exo70 Protects Against Memory and Synaptic Impairments Following Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI), a leading cause of disability in young adults, often results from external forces that damage the brain. Cellularly, mTBI induces oxidative stress, characterized by excessive reactive oxygen species (ROS) and diminished antioxidant capacity. This redox imbalance disrupts hippocampal glutamatergic transmission and synaptic plasticity, where NMDA receptors (NMDARs) are crucial. The […]
Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We systematically searched five databases for studies examining cognitive function in patients with […]
The Diagnostic and Prognostic Role of Biomarkers in Mild Traumatic Brain Injury: An Umbrella Meta-Analysis
CONCLUSIONS: The findings underscore the clinical promise of fluid biomarkers in the management of mTBI. S100B and GFAP are particularly valuable as screening and confirmatory markers, respectively. Nonetheless, further standardization of biomarker thresholds and additional longitudinal studies are necessary to validate the roles of UCH-L1, NfL, and Tau protein. The integration of these biomarkers into […]
Mechanisms Underlying Hyperexcitability: Combining Mossy Fiber Sprouting and Mossy Cell Loss in Neural Network Model of the Dentate Gyrus
Background/Objectives: A concussive head injury increases the likelihood of temporal lobe epilepsy through mechanisms that are not entirely understood. This study aimed to investigate how two key histopathological features shared by both TLE (temporal lobe epilepsy) and head injury-mossy fiber sprouting and hilar excitatory cell loss-contribute to the modulation of dentate gyrus excitability. Methods: A […]
Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury
CONCLUSIONS: Common therapeutic processes, such as focusing on sensitization, might be helpful for these conditions. As for causal mechanisms related to sensitization in the causality of psychological injuries, the major ones hypothesized relate to the biopsychosocial model, psychological control, and activation-inhibition coordination.