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Functional neurological disorders
Living with FND and maintaining quality of life

by Ioannis Mavroudis April 29, 2025

by Ioannis Mavroudis April 29, 2025

Functional Neurological Disorder (FND) causes real, often debilitating neurological symptoms without detectable structural brain damage. …

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High frequency stimulation activates hot spots of spontaneous synaptic transmission
Study Overview The research focuses on understanding the effects of high-frequency stimulation on synaptic transmission…
Increased Risk of Myocardial Infarction in Inclusion Body Myositis: A Non-Concurrent Cohort Study
Cardiovascular Risk Factors in Inclusion Body Myositis The relationship between inclusion body myositis (IBM) and…
Efficacy, safety, and tolerability of chenodeoxycholic acid (CDCA) in adult patients with cerebrotendinous xanthomatosis (RESTORE): a randomized withdrawal, double-blind, placebo-controlled, crossover phase 3 study
Efficacy of Chenodeoxycholic Acid Chenodeoxycholic acid (CDCA) has emerged as a critical therapeutic option for…
Arteriolosclerosis in CNS Tissues Outside the Cerebrum and Late-Life Motor Impairment
Arteriolosclerosis in Non-Cerebral CNS Regions Arteriolosclerosis, a condition characterized by the thickening and hardening of…
FOXG1 Improves Cognitive Function in Alzheimer’s Disease by Promoting Endogenous Neurogenesis
Impact of FOXG1 on Neurogenesis The role of FOXG1 in neurogenesis is increasingly being recognized…

Clinical Cut Point for the Pittsburgh Sleep Quality Index After Adolescent Concussion
CONCLUSION: Adolescents with a concussion demonstrated worse sleep quality than uninjured controls. The results suggest that sleep quality, as measured by the PSQI, can distinguish between adolescents with and without a concussion, using a cut point of 4.
Single-Quantum Sodium MRI at 3T for the Separation of Mono- and Bi-T2 Sodium Signals
Sodium magnetic resonance imaging (MRI) is highly sensitive to cellular ionic balance due to tenfold difference in sodium concentration across membranes, actively maintained by the sodium-potassium (Na ^(+) -K ^(+) ) pump. Disruptions in this pump or membrane integrity, as seen in neurological disorders like epilepsy, multiple sclerosis, bipolar disease, and mild traumatic brain injury, […]
Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter loss in concussive head injury
BACKGROUND: Leukemia Inhibitory Factor (LIF) is an injury-induced cytokine that peaks 48 hours after a traumatic brain injury (TBI). Juvenile LIF haplodeficient mice exhibit desynchronized glial responses, increased neurodegeneration, decreased axonal conductivity and behavioral deficits after a concussive head injury. Given the necessity of LIF during the acute recovery phase after injury, we hypothesized that […]
Role of anxiety in exercise intolerance and autonomic nervous system dysfunction post-concussion
CONCLUSIONS: Adults with pre-existing and post-injury anxiety experienced altered physiological responses to exercise post-concussion and completed fewer stages of the BCBT. Anxiety should be considered by clinicians when interpreting findings from exercise intolerance tests such as the BCBT.
Equestrian STAR: Development of an Experimental Methodology for Assessing the Biomechanical Performance of Equestrian Helmets
CONCLUSION: Pendulum and oblique impacts have different methods of generating head rotation, which can highlight different modes of helmet performance. The updated Equestrian STAR helmet rating system differentiates between high-performing and low-performing helmets, enabling equestrians to purchase helmets best at reducing concussion risk and providing companies with a process to compare their helmet designs.

daily life

Living with FND and maintaining quality of life