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Traumatic brain injury
Psychological interventions for externalising behaviours following paediatric traumatic brain injury: a systematic review and clinical practice recommendations

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Overview of Externalising Behaviours Externalising behaviours refer to a range of actions that move outwardly, …

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Dementia
Resistance and resilience to Alzheimer’s disease in Down syndrome

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Understanding Alzheimer’s Disease in Down Syndrome Alzheimer’s disease (AD) is a multifaceted neurodegenerative condition characterized …

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Stroke
Everyday moderate-to-vigorous physical activity in stroke survivors: the role of individual and joint intentions and self-efficacy

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Study Overview This investigation centered on understanding the dimensions of physical activity among stroke survivors, …

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Functional neurological disorders
MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications-A Review

by myneuronews April 26, 2025

by myneuronews April 26, 2025

Clinical Significance of MTHFR Polymorphisms The MTHFR gene encodes the enzyme methylenetetrahydrofolate reductase, which plays …

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Functional neurological disorders
MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications-A Review

by myneuronews April 26, 2025

by myneuronews April 26, 2025

MTHFR Gene Polymorphisms and Their Role in Health The MTHFR gene, which stands for methylene …

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Functional neurological disorders
FND in teenagers and how to support them

by Ioannis Mavroudis April 26, 2025

by Ioannis Mavroudis April 26, 2025

Functional Neurological Disorder (FND) in teenagers presents real, often distressing symptoms without structural brain damage, …

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Traumatic brain injury
Complexity of post-concussion syndrome assessment and management: a case for customizing rehabilitation

by myneuronews April 25, 2025

by myneuronews April 25, 2025

Understanding Post-Concussion Syndrome Post-Concussion Syndrome (PCS) represents a complex and often debilitating condition that can …

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Traumatic brain injury
Prediction of seizure risk after repetitive mild traumatic brain injury in childhood

by myneuronews April 25, 2025

by myneuronews April 25, 2025

Seizure Risk Factors Seizures are common neurological events that can occur after brain injuries, including …

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Traumatic brain injury
Sport-Related Concussions in High School Athletes: A Comprehensive Update

by myneuronews April 25, 2025

by myneuronews April 25, 2025

Understanding Concussions in High School Sports Concussions have become a significant concern in high school …

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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
CONCLUSIONS: Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI.
Multidisciplinary rehabilitation and follow-up for children hospitalized with traumatic brain injury
PurposeMost children hospitalized with traumatic brain injury (TBI) acquire new impairments that impact function and health-related quality of life. However, there is a lack of standardized, multidisciplinary, longitudinal rehabilitative services for children with TBI.MethodsThis single center, retrospective study evaluated rehabilitative services during acute hospitalization and identified the frequency of unmet needs, defined as new or […]
Tackle characteristics associated with concussion in elite men's rugby union: unpicking the differences between tacklers and ball-carriers
CONCLUSIONS: Lower tackles reduce the chances of concussion to ball-carriers. The influence of tackle height on concussion to tacklers is more nuanced, but the chances are relatively low when contact is made with the ball-carrier's torso. These findings support ongoing implementation of strategies to reduce concussion risk by lowering tackle height to target the torso.
Development of a modified weight-drop apparatus for closed-skull, repetitive mild traumatic brain injuries in a mouse model
Repetitive mild traumatic brain injury (rmTBI) is a major contributor to long-term neurological dysfunction, yet many preclinical models lack precise control and quantification of biomechanical forces across impacts. We developed a reproducible, closed-skull mouse model of rmTBI using a custom-built weight-drop apparatus featuring a solenoid-based rebound arrest system, integrated high-speed videography, and accelerometry to track […]
Pretreatment with an anti-CGRP monoclonal antibody attenuates mild TBI-induced tactile hypersensitivity in mice
CONCLUSIONS: These results indicate that an anti-CGRP mAb can partially, but not fully, attenuate cephalic tactile hypersensitivity when administered immediately before or after the mTBI event. In contrast, a stronger rescue was seen when the anti-CGRP mAb was administered just prior to CGRP and nitric oxide triggers. Thus, depending on the timing of administration, the […]