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GCS

Traumatic brain injury
Brain Ischemia Across Injury Severity in Traumatic Brain Injury and an Association with Abusive Head Trauma

by myneuronews November 21, 2025

by myneuronews November 21, 2025

Pathophysiology of Brain Ischemia Brain ischemia occurs when there is a deficiency of blood supply …

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Traumatic brain injury
Clinical Outcomes in the Patient With Traumatic Brain Injury and Comorbid Obesity: A Scoping Review

by myneuronews November 19, 2025

by myneuronews November 19, 2025

Clinical Outcomes in Traumatic Brain Injury Traumatic brain injury (TBI) represents a significant challenge in …

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Traumatic brain injury
Adoption of brain injury guidelines in mild traumatic brain injury: challenges at both referring and receiving trauma centers

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Guidelines for Mild Traumatic Brain Injury Mild traumatic brain injury (mTBI), often referred to as …

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Traumatic brain injury
Three-Month Outcomes of Traumatic Brain Injury in the General Population: A Sunnybrook Traumatic Brain Injury Cohort Study

by myneuronews November 10, 2025

by myneuronews November 10, 2025

Study Overview The investigation examines the aftermath of traumatic brain injuries (TBIs) within a diverse …

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Traumatic brain injury
A novel multimodal pharmacologic approach using guanfacine, N-acetylcysteine, and donepezil in severe TBI: a case series

by myneuronews November 10, 2025

by myneuronews November 10, 2025

Study Overview This study presents a novel approach to treating severe traumatic brain injury (TBI) …

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Traumatic brain injury
Beyond mild, moderate, and severe traumatic brain injury: modelling severity from clinical, neuroimaging, and blood-based indicators

by myneuronews November 5, 2025

by myneuronews November 5, 2025

Understanding Traumatic Brain Injury Severity Traumatic brain injury (TBI) manifests in varying degrees of severity, …

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Traumatic brain injury
Traumatic Microbleeds in Mild Traumatic Brain Injury: Stability, Distribution, and Association with Other Injuries

by myneuronews October 31, 2025

by myneuronews October 31, 2025

Traumatic Microbleeds Characteristics Traumatic microbleeds (TMBs) are small, focal areas of hemorrhage within the brain …

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Functional neurological disorders
Neurological Emergencies in Incarcerated Patients: Clinical Characteristics, Severity, and Outcomes in an Emergency Department with an Embedded Neuro-Emergency Expert Model

by myneuronews October 29, 2025

by myneuronews October 29, 2025

Clinical Characteristics of Neurological Emergencies Neurological emergencies in incarcerated patients present a unique set of …

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Functional neurological disorders
Neurological Emergencies in Incarcerated Patients: Clinical Characteristics, Severity, and Outcomes in an Emergency Department with an Embedded Neuro-Emergency Expert Model

by myneuronews October 29, 2025

by myneuronews October 29, 2025

Clinical Characteristics of Neurological Emergencies Neurological emergencies encompass a spectrum of acute conditions affecting the …

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Traumatic brain injury
The clinical significance of serum LY86-AS1 in the early detection and prognostic evaluation of traumatic brain injury

by myneuronews October 28, 2025

by myneuronews October 28, 2025

Serum LY86-AS1 and Traumatic Brain Injury Recent research indicates that LY86-AS1, a long non-coding RNA, …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]