Tag:

GFAP

Traumatic brain injury
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury

by myneuronews January 10, 2026

by myneuronews January 10, 2026

Study Overview This investigation focuses on the effects of N-stearidonoylethanolamine (NSE) in addressing synaptic deficits …

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Traumatic brain injury
Plasma biomarkers in chronic mild traumatic brain injury: A review

by myneuronews December 31, 2025

by myneuronews December 31, 2025

Biomarkers in Chronic Mild Traumatic Brain Injury Chronic mild traumatic brain injury (mTBI), commonly associated …

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Traumatic brain injury
Plasma biomarkers in chronic mild traumatic brain injury: A review

by myneuronews December 31, 2025

by myneuronews December 31, 2025

Biomarkers in Chronic Mild Traumatic Brain Injury Chronic mild traumatic brain injury (mTBI) is a …

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Traumatic brain injury
Prognostic value of GFAP and UCHL-1 biomarkers in high-risk mild traumatic brain injury: A prospective longitudinal study of short- and long-term outcomes

by myneuronews December 27, 2025

by myneuronews December 27, 2025

Study Overview The research focused on evaluating the prognostic significance of glial fibrillary acidic protein …

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Traumatic brain injury
Neuronal and Glial Biomarkers in Urine of Athletes with Different Risks of Head Trauma to Monitor Sports-Related Concussions

by myneuronews December 19, 2025

by myneuronews December 19, 2025

Biomarkers in Sports-Related Concussions Sports-related concussions (SRC) represent a significant public health concern, particularly among …

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Traumatic brain injury
Neuronal and Glial Biomarkers in Urine of Athletes with Different Risks of Head Trauma to Monitor Sports-Related Concussions

by myneuronews December 19, 2025

by myneuronews December 19, 2025

Biomarkers in Urine The detection of biomarkers in urine has emerged as a promising method …

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Traumatic brain injury
Plasma and Imaging Biomarker Changes Following Rotational and Contusional Models of Traumatic Brain Injury in Adolescent Pigs

by myneuronews December 10, 2025

by myneuronews December 10, 2025

Study Overview This research investigates the biochemical and imaging alterations resulting from two distinct forms …

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Dementia
Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain

by myneuronews December 9, 2025

by myneuronews December 9, 2025

Study Overview The study investigated the changes in specific biomarkers in the blood of patients …

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Traumatic brain injury
Mechanisms of naozhenning in inhibiting neuronal ferroptosis and alleviating brain recurrent mild traumatic brain injury in a rat model

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Mechanisms of Ferroptosis Inhibition Ferroptosis is a distinct form of regulated cell death characterized by …

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Traumatic brain injury
Brain Ischemia Across Injury Severity in Traumatic Brain Injury and an Association with Abusive Head Trauma

by myneuronews November 21, 2025

by myneuronews November 21, 2025

Pathophysiology of Brain Ischemia Brain ischemia occurs when there is a deficiency of blood supply …

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Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]