Tag:

ImPACT

Headaches
Efficacy, safety, and tolerability of chenodeoxycholic acid (CDCA) in adult patients with cerebrotendinous xanthomatosis (RESTORE): a randomized withdrawal, double-blind, placebo-controlled, crossover phase 3 study

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Efficacy of Chenodeoxycholic Acid Chenodeoxycholic acid (CDCA) has emerged as a critical therapeutic option for …

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Traumatic brain injury
Early Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Early Pupil Abnormality and Its Significance Pupil abnormalities, such as asymmetry or non-reactivity to light, …

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Traumatic brain injury
Effects of Subanesthetic Intravenous Ketamine Infusion on Stress Hormones and Synaptic Density in Rats with Mild Closed-Head Injury

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Effects of Ketamine on Stress Hormones Research on the impact of ketamine, particularly in its …

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Traumatic brain injury
Single-Quantum Sodium MRI at 3T for the Separation of Mono- and Bi-T2 Sodium Signals

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Study Overview The study investigates an innovative approach to magnetic resonance imaging (MRI) aimed at …

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Traumatic brain injury
Clinical Cut Point for the Pittsburgh Sleep Quality Index After Adolescent Concussion

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Clinical Relevance of Sleep Quality Sleep quality is a pivotal aspect of overall health and …

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Dementia
FOXG1 Improves Cognitive Function in Alzheimer’s Disease by Promoting Endogenous Neurogenesis

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Impact of FOXG1 on Neurogenesis The role of FOXG1 in neurogenesis is increasingly being recognized …

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Traumatic brain injury
Retinal manifestations of traumatic brain injury

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Retinal Changes Associated with Traumatic Brain Injury Traumatic brain injury (TBI) can lead to various …

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Traumatic brain injury
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Study Overview The research undertaken aimed to establish a reliable and straightforward model of mild …

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Traumatic brain injury
Equestrian STAR: Development of an Experimental Methodology for Assessing the Biomechanical Performance of Equestrian Helmets

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Study overview The research aimed to establish a novel methodology for evaluating the biomechanical performance …

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Dementia
Resistance and resilience to Alzheimer’s disease in Down syndrome

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Understanding Alzheimer’s Disease in Down Syndrome Alzheimer’s disease (AD) is a multifaceted neurodegenerative condition characterized …

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Study of ubiquitin C-terminal hydrolase-L1, glial fibrillary acidic protein, and interleukin-6 levels in an experimental head trauma model in rabbits
CONCLUSION: Serum UCH-L1 differentiated moderate and severe trauma from controls in a rabbit model, whereas CSF GFAP and IL-6 levels reflected severe injury. Validation in larger preclinical and clinical studies is warranted.
Correlation of Optic Nerve Sheath Diameter With Severity and Outcome in Head Injury: Ultrasonographic and CT Evaluation
Objective This study aimed to determine the extent to which ultrasonographic and computed tomographic (CT) measurements of the optic nerve sheath diameter (ONSD) correlate with the prognosis and severity of traumatic brain injury (TBI). Methodology A prospective cohort study was conducted among 200 adult patients admitted to a Level 1 trauma center over one year. […]
Admission blood glucose and neutrophil-to-lymphocyte ratio for differentiating CT-positive from CT-negative mild traumatic brain injury
This study aimed to assess the diagnostic utility of routine laboratory biomarkers in adults with mTBI. We conducted a prospective study of patients who were admitted to the neurosurgical department with mTBI, had admission laboratory data available, and a brain CT scan was performed. The cohort included 101 patients (mean age: 59 ± 23.14 years). […]
Bidirectional Relationship Between Mental Health and Sports Injury in Adolescents: A Systematic Review and Meta-analysis
CONCLUSIONS: We found evidence for a bidirectional relationship between sports injuries and mental health in adolescent athletes. Further research is needed to elucidate the mechanisms underlying this relationship. Early interventions focusing on supporting mental health after sports injury, and addressing pre-existing mental health issues to reduce the risk of subsequent injury, should be tailored towards […]
Does Timing of Concussion in Season Affect Incidence and Recovery in Division I Collegiate Football Players? A CARE Consortium Study
CONCLUSIONS: In a multi-institution cohort of collegiate football players, preseason resulted in the highest incidence of concussions, while early and late-season concussions had significantly longer time to SR compared to preseason. These temporal patterns suggest that contextual factors may influence concussion outcomes and warrant mechanistic investigation to inform future management strategies.