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Dementia
FOXG1 Improves Cognitive Function in Alzheimer’s Disease by Promoting Endogenous Neurogenesis

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Impact of FOXG1 on Neurogenesis The role of FOXG1 in neurogenesis is increasingly being recognized …

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Functional neurological disorders
Imbalanced goal-directed and habitual control in individuals with internet gaming disorder

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Understanding Internet Gaming Disorder Internet Gaming Disorder (IGD) has emerged as a significant concern in …

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Dementia
Resistance and resilience to Alzheimer’s disease in Down syndrome

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Understanding Alzheimer’s Disease in Down Syndrome Alzheimer’s disease (AD) is a multifaceted neurodegenerative condition characterized …

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Stroke
Everyday moderate-to-vigorous physical activity in stroke survivors: the role of individual and joint intentions and self-efficacy

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Study Overview This investigation centered on understanding the dimensions of physical activity among stroke survivors, …

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Functional neurological disorders
MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications-A Review

by myneuronews April 26, 2025

by myneuronews April 26, 2025

Clinical Significance of MTHFR Polymorphisms The MTHFR gene encodes the enzyme methylenetetrahydrofolate reductase, which plays …

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Functional neurological disorders
MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications-A Review

by myneuronews April 26, 2025

by myneuronews April 26, 2025

MTHFR Gene Polymorphisms and Their Role in Health The MTHFR gene, which stands for methylene …

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Traumatic brain injury
Complexity of post-concussion syndrome assessment and management: a case for customizing rehabilitation

by myneuronews April 25, 2025

by myneuronews April 25, 2025

Understanding Post-Concussion Syndrome Post-Concussion Syndrome (PCS) represents a complex and often debilitating condition that can …

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Traumatic brain injury
Clinical manifestations and treatment of hypopituitarism due to traumatic brain injury

by myneuronews April 25, 2025

by myneuronews April 25, 2025

Understanding Hypopituitarism Hypopituitarism is a condition characterized by the insufficient production of one or more …

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Traumatic brain injury
Prediction of seizure risk after repetitive mild traumatic brain injury in childhood

by myneuronews April 25, 2025

by myneuronews April 25, 2025

Seizure Risk Factors Seizures are common neurological events that can occur after brain injuries, including …

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Functional neurological disorders
Gut Neuropeptide Involvement in Parkinson’s Disease

by myneuronews April 25, 2025

by myneuronews April 25, 2025

Gut Neuropeptides and Their Role in Neurodegeneration Gut neuropeptides are crucial biochemical messengers that play …

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Exo70 Protects Against Memory and Synaptic Impairments Following Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI), a leading cause of disability in young adults, often results from external forces that damage the brain. Cellularly, mTBI induces oxidative stress, characterized by excessive reactive oxygen species (ROS) and diminished antioxidant capacity. This redox imbalance disrupts hippocampal glutamatergic transmission and synaptic plasticity, where NMDA receptors (NMDARs) are crucial. The […]
Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We systematically searched five databases for studies examining cognitive function in patients with […]
The Diagnostic and Prognostic Role of Biomarkers in Mild Traumatic Brain Injury: An Umbrella Meta-Analysis
CONCLUSIONS: The findings underscore the clinical promise of fluid biomarkers in the management of mTBI. S100B and GFAP are particularly valuable as screening and confirmatory markers, respectively. Nonetheless, further standardization of biomarker thresholds and additional longitudinal studies are necessary to validate the roles of UCH-L1, NfL, and Tau protein. The integration of these biomarkers into […]
Mechanisms Underlying Hyperexcitability: Combining Mossy Fiber Sprouting and Mossy Cell Loss in Neural Network Model of the Dentate Gyrus
Background/Objectives: A concussive head injury increases the likelihood of temporal lobe epilepsy through mechanisms that are not entirely understood. This study aimed to investigate how two key histopathological features shared by both TLE (temporal lobe epilepsy) and head injury-mossy fiber sprouting and hilar excitatory cell loss-contribute to the modulation of dentate gyrus excitability. Methods: A […]
Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury
CONCLUSIONS: Common therapeutic processes, such as focusing on sensitization, might be helpful for these conditions. As for causal mechanisms related to sensitization in the causality of psychological injuries, the major ones hypothesized relate to the biopsychosocial model, psychological control, and activation-inhibition coordination.