Tag:

metabolomics

Traumatic brain injury
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity

by myneuronews November 14, 2025

by myneuronews November 14, 2025

Metabolomic Profiling Metabolomic profiling involves the comprehensive analysis of metabolites—small molecules that are the end …

Read more

0 Facebook Twitter Pinterest Email
Traumatic brain injury
Beyond mild, moderate, and severe traumatic brain injury: modelling severity from clinical, neuroimaging, and blood-based indicators

by myneuronews November 5, 2025

by myneuronews November 5, 2025

Understanding Traumatic Brain Injury Severity Traumatic brain injury (TBI) manifests in varying degrees of severity, …

Read more

0 Facebook Twitter Pinterest Email
Dementia
Systematic post-translational modification genome wide identifies therapeutic targets for Alzheimer’s disease: evidence from multi-cohort analysis

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Identifying Therapeutic Targets In recent years, identifying therapeutic targets for Alzheimer’s disease (AD) has gained …

Read more

0 Facebook Twitter Pinterest Email
Traumatic brain injury
Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25

by myneuronews October 18, 2025

by myneuronews October 18, 2025

Exosome Characteristics Exosomes are small extracellular vesicles that range from 30 to 150 nanometers in …

Read more

0 Facebook Twitter Pinterest Email
Functional neurological disorders
Serum biomarkers in epilepsy: More than meets the eye

by myneuronews October 10, 2025

by myneuronews October 10, 2025

Serum Biomarkers in Epilepsy Recent research has increasingly focused on serum biomarkers as valuable tools …

Read more

0 Facebook Twitter Pinterest Email
Functional neurological disorders
Serum biomarkers in epilepsy: More than meets the eye

by myneuronews October 10, 2025

by myneuronews October 10, 2025

Serum Biomarkers Overview Serum biomarkers have emerged as a critical aspect of understanding and diagnosing …

Read more

0 Facebook Twitter Pinterest Email
Traumatic brain injury
Exercise-induced molecular modulation following mTBI: A multi-omics study in male mice

by myneuronews October 9, 2025

by myneuronews October 9, 2025

Study Overview This study investigates the effects of exercise on molecular changes following a mild …

Read more

0 Facebook Twitter Pinterest Email
Functional neurological disorders
Investigating the role of a novel hemizygous FAAH2 variant in neurological and metabolic disorders

by myneuronews July 31, 2025

by myneuronews July 31, 2025

Role of FAAH2 in Neurological Disorders FAAH2, or fatty acid amide hydrolase 2, is an …

Read more

0 Facebook Twitter Pinterest Email
Functional neurological disorders
Integrated Transcriptomic Analysis Provided Diagnostic and Pathophysiological Insights for Epilepsy

by myneuronews July 23, 2025

by myneuronews July 23, 2025

Integrated Transcriptomic Insights Recent advancements in transcriptomic analysis have opened new avenues for understanding the …

Read more

0 Facebook Twitter Pinterest Email
Dementia
Embracing the Modern Biochemistry of Brain Metabolism

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Understanding Brain Metabolism The brain is an extraordinarily energy-demanding organ, consuming approximately 20% of the …

Read more

0 Facebook Twitter Pinterest Email

Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review
Traumatic brain injury (TBI) represents a significant health concern, with an estimated 70 million annual cases worldwide. Mild brain trauma (concussions) is the most common TBI (81%), followed by moderate (11%) and severe (8%). Cytokine release and neuroinflammation after TBI may cause blood-brain barrier and tissue damage, triggering unfavorable outcomes, including disabilities and mortality. Current […]
N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) disrupts hippocampal network function through coordinated alterations in glial reactivity, synaptic integrity, and adult neurogenesis. Effective therapeutic approaches targeting these interconnected processes remain limited. Lipid-derived molecules capable of modulating these mTBI-induced disturbances are emerging as promising neuroprotective candidates. Here, we investigated the effects of N-stearidonylethanolamine (SDEA), an ω-3 ethanolamide, in […]
Effects of persistent post-concussion symptoms on neurocognitive, motor, and neurophysiological outcomes
CONCLUSION: The PPCS group demonstrated greater symptom reporting and severity, worse neurocognitive performance, worse balance and gait performance, and altered neurophysiology. Further, females with PPCS demonstrated worse balance and gait performance compared to all other groups.
Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis
CONCLUSION: Our study untangles a "priming-triggering" mechanism of injury-environment interaction, identifying the HMGB1-RAGE axis as its key molecular mediator. This finding not only enhances our understanding of how latent vulnerability transitions into overt neuropsychiatric disease, but also provides a promising target for preventive intervention.
Relationship between illness perceptions, coping style and post-concussion symptoms after systemic traumatic injury: A comparison of those with and without mild traumatic brain injury
Research has reported variable findings when investigating the relationship between outcome and coping style and illness perceptions after mild traumatic brain injury (mTBI). The present study investigated 138 individuals who had been admitted to hospital after suffering a traumatic systemic injury, with 91 of these individuals also fulfilling criteria for mTBI and 47 comprising a […]