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multiomics

Functional neurological disorders
Spatial Multiomics Toward Understanding Neurological Systems

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Understanding Spatial Multiomics Spatial multiomics is revolutionizing our understanding of the brain and its complex …

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Medical professionals Traumatic brain injury
Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

by Ioannis Mavroudis March 22, 2024

by Ioannis Mavroudis March 22, 2024

Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

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Unsophisticated AI coaching does not improve performance on symptom and performance validity tests in a Romanian sample of experimental feigners
The present study aimed to investigate the ability of symptom and performance validity indicators to detect experimental feigning with symptom-coaching vs. AI assistance. Fifty-nine undergraduates and community members (45 females, M(Age)=22.6, SD(Age)=2.1; M(Education)=14.5, SD(Education)=1.4) were randomized into three experimental groups: controls (n = 20), symptom-coached feigners (n = 20), and AI-coached feigners (n = 19). […]
Factors affecting mortality risk in pediatric head injuries in Africa: a meta-analysis
CONCLUSION: Our study emphasizes RTA and seizures at presentation as key risk factors for mortality. We recommend early preventive measures, such as infrastructure improvements, to enhance road safety and reduce mortality.
Nonsteroid Anti-Inflammatory Drug Use in Female Elite Ice Hockey Players With and Without Previous Concussions and Musculoskeletal Injuries
Ice hockey is a high-intensity sport with high rates of concussions and musculoskeletal injuries. To manage pain, players may (over) use nonsteroid anti-inflammatory drugs (NSAIDs) which can have adverse health effects. In 2022, the Swedish Women's Elite League (SDHL) became the first women's league to introduce body checking, potentially increasing injury risks and NSAID use. […]
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice
The mammalian brainstem is particularly vulnerable to mild traumatic brain injury (mTBI), which is associated with prolonged autonomic dysfunction and coma. The spatial cellular connections within the brainstem or the mechanisms underlying its response to injury have been underestimated. Here, we performed single-nucleus RNA sequencing with spatial transcriptome sequencing in both normal and mTBI brainstems […]
Post-Concussion Changes in the Functional Brain Connectome Relative to Pre-Injury Baseline: A Prospective Observational Study
There is growing concern about the long-term health consequences of concussion, stemming from its high incidence and evidence of post-injury sequelae. This has raised critical questions about clinical assessments of concussion recovery, and whether brain function has fully recovered at medical clearance. The major knowledge gap is only partly addressed by conventional cross-sectional neuroimaging studies, […]

multiomics

Spatial Multiomics Toward Understanding Neurological Systems

Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies