Two Novel Variants in MT-RNR1 Gene Associated with Hereditary Optic Neuropathy: A Case Report
Study Overview Hereditary optic neuropathy comprises a group of genetic disorders characterized by the degeneration of retinal ganglion cells, leading […]
The Dual Role of Connexins in Stroke, Neurotrauma, Neurodegenerative and Psychiatric Disorders: A Global Systematic Review
Background on Connexins Connexins are a family of integral membrane proteins that form gap junctions, which are specialized intercellular channels
The Role of Cytokines in Traumatic Brain Injury
Impact of Cytokines on Neuroinflammation Cytokines play a pivotal role in the immune response of the central nervous system, particularly
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An unrecognized mechanism of neuroprotection by microglial TIA1-mediated stress granules to prevent neuroinflammation and demyelination in experimental autoimmune encephalomyelitis mice through sequestering ApoE mRNA
Mechanism of TIA1-Mediated Neuroprotection The immune response in the central nervous system (CNS) plays a critical role in maintaining homeostasis
Spleen-brain axis regulates myelin integrity via TGF-beta1 signaling in cuprizone-induced demyelination and remyelination model
Spleen-brain axis and myelin integrity The connection between the spleen and brain is a crucial aspect of the immune system’s
Cognitive Reserve in rural and urban populations: Insights from two aging cohorts in southern India
Cognitive Reserve Defined Cognitive reserve refers to the brain’s resilience to neuropathological damage and its capacity to maintain cognitive function
Raloxifene Beyond Osteoporosis: Unlocking Neurorestoration Through Remyelination, Inflammatory Regulation, and Neuroimmune Modulation in CNS Pathologies
Raloxifene Mechanisms in Neurorestoration Raloxifene, a selective estrogen receptor modulator (SERM), is primarily known for its role in the treatment
Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice
Study Overview This investigation centers on the roles of two pharmacological agents, Metformin and Pioglitazone, in modulating the activation state
Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia
Pathophysiological Mechanisms The pathophysiology underlying Purkinje cell-specific disruptions in neurofascin and ankyrin G reveals critical insights into the mechanisms that
Amyotrophic lateral sclerosis and chronic inflammatory demyelinating polyneuropathy coexistence in a patient with a C9orf72 variant: case report
Coexistence of Conditions Amyotrophic lateral sclerosis (ALS) and chronic inflammatory demyelinating polyneuropathy (CIDP) represent two distinct neurological disorders, yet their