Tag:

neurodegenerative diseases

Functional neurological disorders
Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy

by myneuronews May 25, 2025

by myneuronews May 25, 2025

Cytoplasmic Role of DDX11 in Autophagy Recent research has unveiled a novel cytoplasmic function of …

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Functional neurological disorders
Developing a disease-specific accessible transcriptional signature as a biomarker for ataxia with oculomotor apraxia type 2

by myneuronews May 24, 2025

by myneuronews May 24, 2025

Background of Ataxia with Oculomotor Apraxia Type 2 Ataxia with oculomotor apraxia type 2 (AOA2) …

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Functional neurological disorders
Fully biodegradable dendrimers as novel nanodrugs for amyloid-β-induced neurotoxicity

by myneuronews May 23, 2025

by myneuronews May 23, 2025

Biodegradable Dendrimers: A Novel Approach Dendrimers are highly branched molecules that can be customized at …

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Traumatic brain injury
Exercise plasma improves traumatic brain injury outcomes in mice

by myneuronews May 23, 2025

by myneuronews May 23, 2025

Exercise-Induced Plasma Effects Physical activity is known to have numerous beneficial effects on health, particularly …

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Functional neurological disorders
Fully biodegradable dendrimers as novel nanodrugs for amyloid-β-induced neurotoxicity

by myneuronews May 23, 2025

by myneuronews May 23, 2025

Material and Methods The study on fully biodegradable dendrimers as novel nanodrugs targeting amyloid-β-induced neurotoxicity …

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Functional neurological disorders
Regulating aggregation of an intrinsically disordered chaperone-like casein

by myneuronews May 22, 2025

by myneuronews May 22, 2025

Characterization of Intrinsically Disordered Chaperone-Like Casein The study of intrinsically disordered proteins (IDPs) has become …

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Functional neurological disorders
Functional neurological disorder: Practical management

by myneuronews May 21, 2025

by myneuronews May 21, 2025

Understanding Functional Neurological Disorder Functional Neurological Disorder (FND) represents a complex interplay between neurological and …

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Stroke
Novel Perivascular Macrophage Mechanism to Promote Glymphatic Abeta Clearance After Stroke

by myneuronews May 20, 2025

by myneuronews May 20, 2025

Mechanism of Glymphatic Clearance The glymphatic system is a unique network that plays a pivotal …

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Traumatic brain injury
Genome-wide analysis of lncRNA m6A methylation in the mouse cortex after repetitive mild traumatic brain injury

by myneuronews May 20, 2025

by myneuronews May 20, 2025

Background on lncRNA and m6A Methylation Long non-coding RNAs (lncRNAs) are an intriguing class of …

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Movement Disorders
Evaluating the Homogeneity of the PSP-RS Syndrome beyond Core Features

by myneuronews May 19, 2025

by myneuronews May 19, 2025

Evaluate the Homogeneity of PSP-RS Syndrome The Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) represents a specific …

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Performance and Physiological Response to the Buffalo Concussion Treadmill Test Can Identify Autonomic Dysfunction in the General Adult Population With Mild Traumatic Brain Injury: A Prospective Observational Study
CONCLUSION: This study demonstrates that the inability to exercise to a threshold HR of 90% of an individual's age-predicted maximum HR is a better indicator of autonomic dysfunction. HRR may be prolonged in those with a mild TBI, but caution should be taken if attributing this to physiological dysfunction as the predominant factor appears to […]
The Experience of Return to Work Among People with Persistent Symptoms Following a Concussion: An Interview Study
CONCLUSION: Recognition in daily life seem to play a key role in the RTW process for individuals with persistent symptoms following a concussion. They struggle to balance their limitations to match their desire to both work and family life. The support they received was often random and they felt lonely. The findings reflect the participant's […]
Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods
Military service members (SMs) and veterans who have sustained one or more concussions during their service have significantly higher rates of persistent depressive symptoms and suicidality compared to non-injured peers. Despite over 500,000 SMs who have sustained concussions, there are currently no Level I evidence-based treatments for improving depressive symptoms associated with concussion. Accelerated intermittent […]
Dietary Intake of n-3 Polyunsaturated Fatty Acids Prior to a Mild Traumatic Brain Injury Demonstrates a Dose-Response Effect for Neuroprotective Benefits in Male C57BL/6 Mice
CONCLUSIONS: Overall, these results show that dietary n-3 PUFA confer neuroprotective benefits in mice resulting in significantly improved functional outcomes. This work is relevant to clinical practitioners, athletes, and the general population who aim to support their neurological health through dietary or supplementary n-3 PUFA.
Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury
CONCLUSIONS AND RELEVANCE: BDNF DNAm appears to differ in children with TBI vs OI, particularly in the acute period. BDNF DNAm differences may reflect early biological responses that are specific to TBI.