Tag:

neuroinflammatory response

Traumatic brain injury
Development of a modified weight-drop apparatus for closed-skull, repetitive mild traumatic brain injuries in a mouse model

by myneuronews December 4, 2025

by myneuronews December 4, 2025

Study Overview This research focuses on creating a refined apparatus designed to induce mild traumatic …

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Traumatic brain injury
The kynurenine pathway in pediatric “mild-to-moderate” traumatic brain injury: translational insights from a prospective human study and a large-animal model

by myneuronews November 21, 2025

by myneuronews November 21, 2025

Kynurenine Pathway Mechanisms The kynurenine pathway is a critical metabolic route for the amino acid …

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Traumatic brain injury
Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury

by myneuronews November 19, 2025

by myneuronews November 19, 2025

Study Overview The investigation into the effects of targeted complement inhibition on outcomes following repetitive …

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Dementia
Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD-1 mutant mice

by myneuronews November 15, 2025

by myneuronews November 15, 2025

Impact of C9orf72 Loss on Neuromuscular Systems The loss of the C9orf72 gene has been …

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Traumatic brain injury
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

by myneuronews November 8, 2025

by myneuronews November 8, 2025

Therapeutic Efficacy of VEGFC The treatment of traumatic brain injury (TBI) has been a significant …

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Traumatic brain injury
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Study Overview This research examines the impact of engineered rotational acceleration on axonal injury in …

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Traumatic brain injury
Changes in peripheral blood and cognitive performance after nonconcussive head impacts in elite female soccer players

by myneuronews October 7, 2025

by myneuronews October 7, 2025

Study Overview The research investigates the effects of nonconcussive head impacts on both the peripheral …

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Traumatic brain injury
Spautin-1 alleviates depression-like behaviors in mice after traumatic brain injury by inhibiting MMP3 expression in microglia in the Hippocampal CA1 region

by myneuronews September 12, 2025

by myneuronews September 12, 2025

Study Overview The research in question investigates the effects of Spautin-1, a compound known for …

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Functional neurological disorders
Somatic Symptom and Related Disorders and Mild Traumatic Brain Injury: A Systematic Review

by myneuronews September 2, 2025

by myneuronews September 2, 2025

Somatic Symptom Overview Somatic symptom disorders encompass a range of conditions characterized by the presence …

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Traumatic brain injury
Vibrational spectroscopy methods reveal biochemical changes associated with the glial scar formation after traumatic brain injury

by myneuronews August 9, 2025

by myneuronews August 9, 2025

Biochemical Changes in Glial Scarring After a traumatic brain injury (TBI), the central nervous system …

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Neurotrauma induced retinal basement membrane COL4A1 defects are restored by adipose tissue derived mesenchymal stem cell concentrated conditioned medium
CONCLUSIONS: These findings collectively identify COL4A1 deficiency as a sensitizing factor for post-traumatic visual dysfunction and demonstrate that ASC-CCM exerts therapeutic effects by preserving retinal vascular structure and modulating inflammatory responses, positioning it as a promising candidate for treating TBI-related ocular neurovascular injury.
Hollow CuS nanocubes enhance serum metabolic profiles for rapid diagnosis and severity grading of traumatic brain injury
Traumatic brain injury (TBI) remains a significant global health burden and demands rapid, objective diagnostics that work outside imaging suites and intensive lab workflows. Here, we developed a copper sulfide (CuS) nanocube-assisted laser desorption/ionization mass spectrometry (LDI-MS) platform to acquire serum metabolic profiles (SMPs) with high sensitivity, low background in the low-m/z region, and excellent […]
Attention-Deficit/Hyperactivity Disorder Following Mild Traumatic Brain Injury in Children: A Retrospective Exploratory Study
Introduction This study examines whether attention-deficit/hyperactivity disorder (ADHD) can develop after traumatic brain injury in children. Overlapping acute symptoms can hinder early identification and diagnosis. We investigated whether demographic or acute clinical features are associated with the development of secondary ADHD (S-ADHD) following mild pediatric traumatic brain injury. Materials and methods We conducted a retrospective […]
Ultra-high contrast MRI: a new technique for recognizing secondary changes to the brain in patients with persistent symptoms following traumatic brain injury
CONCLUSION: The whiteout sign was strongly associated with being in the symptomatic group and is a potential biomarker for recognition of secondary changes to the brain in patients with persistent symptoms following TBI.
Transcranial direct current stimulation (tDCS) in conscious mice: a refined method for repetitive applications without restraint
Transcranial direct current stimulation (tDCS) for painless, non-invasive brain stimulation is a promising approach to enhance recovery after stroke. However, the precise molecular and cellular mechanisms underlying the effects of tDCS remain unclear, impeding its use in humans and necessitating research in experimental animals. Unlike humans, who receive tDCS fully awake, experimental models of tDCS […]