Tag:

neuroinflammatory response

Traumatic brain injury
The kynurenine pathway in pediatric “mild-to-moderate” traumatic brain injury: translational insights from a prospective human study and a large-animal model

by myneuronews November 21, 2025

by myneuronews November 21, 2025

Kynurenine Pathway Mechanisms The kynurenine pathway is a critical metabolic route for the amino acid …

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Traumatic brain injury
Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury

by myneuronews November 19, 2025

by myneuronews November 19, 2025

Study Overview The investigation into the effects of targeted complement inhibition on outcomes following repetitive …

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Dementia
Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD-1 mutant mice

by myneuronews November 15, 2025

by myneuronews November 15, 2025

Impact of C9orf72 Loss on Neuromuscular Systems The loss of the C9orf72 gene has been …

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Traumatic brain injury
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

by myneuronews November 8, 2025

by myneuronews November 8, 2025

Therapeutic Efficacy of VEGFC The treatment of traumatic brain injury (TBI) has been a significant …

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Traumatic brain injury
Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets

by myneuronews October 30, 2025

by myneuronews October 30, 2025

Study Overview This research examines the impact of engineered rotational acceleration on axonal injury in …

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Traumatic brain injury
Changes in peripheral blood and cognitive performance after nonconcussive head impacts in elite female soccer players

by myneuronews October 7, 2025

by myneuronews October 7, 2025

Study Overview The research investigates the effects of nonconcussive head impacts on both the peripheral …

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Traumatic brain injury
Spautin-1 alleviates depression-like behaviors in mice after traumatic brain injury by inhibiting MMP3 expression in microglia in the Hippocampal CA1 region

by myneuronews September 12, 2025

by myneuronews September 12, 2025

Study Overview The research in question investigates the effects of Spautin-1, a compound known for …

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Functional neurological disorders
Somatic Symptom and Related Disorders and Mild Traumatic Brain Injury: A Systematic Review

by myneuronews September 2, 2025

by myneuronews September 2, 2025

Somatic Symptom Overview Somatic symptom disorders encompass a range of conditions characterized by the presence …

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Traumatic brain injury
Vibrational spectroscopy methods reveal biochemical changes associated with the glial scar formation after traumatic brain injury

by myneuronews August 9, 2025

by myneuronews August 9, 2025

Biochemical Changes in Glial Scarring After a traumatic brain injury (TBI), the central nervous system …

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Functional neurological disorders
Wogonin Inhibits Oxidative Stress in Hypoxia-Induced hCMEC/D3 Cells Through Suppressing CXCL8-Mediated TLR4/NF-κB Pathway

by myneuronews July 4, 2025

by myneuronews July 4, 2025

Mechanisms of Wogonin Action Wogonin, a naturally occurring flavonoid derived from the plant Scutellaria baicalensis, …

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Transitions in Independent Living, Productivity, and Social Relationships Among Individuals Sustaining Traumatic Brain Injury in Adolescence: A TBI Model Systems Investigation
OBJECTIVE: To characterize transitions in independent living, productivity, and social relationships over the first 5 years postinjury among adolescents sustaining complicated mild to severe traumatic brain injury (TBI) between ages 16 and 18.
Impact of prior concussion history on concussion symptoms and health-related quality of life in an underrepresented and historically excluded population
CONCLUSION: Black/African American adolescent athletes with a history of concussion endorsed higher concussion symptoms, higher symptom severity, and more psychological stress. This underscores the importance of incorporating HRQoL measures post-injury and the inclusion of underrepresented populations to promote a more holistic understanding of concussions.
Retrospective Evaluation of Stair-Related Injuries in Dogs Presenting to Emergency Centers: 61 Cases (2017-2022)
CONCLUSION: Falls involving stairs are associated with various forms of injury in dogs. Many cases were mild, allowing for outpatient management. In some cases, it may be difficult to determine whether the fall caused the injury or whether disease precipitated the fall (e.g., myelopathy, pathological fracture). The small sample size of this population likely limited […]
Sport-related Concussion Can be Prevented by Injury Prevention Program: A Systematic Review and Meta-analysis of Prospective, Controlled Studies
CONCLUSIONS: SRC prevention programs provided a significant protection effect, reducing injury rates by 34%. Importantly, their efficacy remains consistent across both physical training and educational-based programs, as well as in various exposure contexts. However, further prospective studies are needed to develop injury prevention protocols specifically for females and to investigate factors that may influence the […]
Brain Ischemia Across Injury Severity in Traumatic Brain Injury and an Association with Abusive Head Trauma
CONCLUSIONS: Ischemia was associated with AHT and unfavorable outcomes. Ischemia in mild AHT suggests an unrecognized injury. Further work is needed to determine whether early MRI may be an important tool to detect ischemia and AHT.