Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins
Study Overview The research investigates the mechanisms by which macrophages and microglia, two types of immune cells in the central […]
Apolipoprotein E Deficiency Attenuates Neuroinflammatory Responses and Demyelination in Experimental Autoimmune Encephalomyelitis
Study Overview Recent research has illuminated the pivotal role of Apolipoprotein E (ApoE) in modulating immune responses within the central
Plumbagin Ameliorates Multiple Sclerosis by Inducing DDX3X-Mediated Stress Granule Assembly in Mice
Mechanism of Action The therapeutic effects of plumbagin in the context of multiple sclerosis (MS) appear to stem from its
Male mice are particularly vulnerable to cognitive impairment following mTBI
Cognitive Vulnerability in Male Mice Research has demonstrated that male mice exhibit an increased susceptibility to cognitive deficits following mild
Male mice are particularly vulnerable to cognitive impairment following mTBI Read Post »
Comparative Analysis of Mouse CSF Proteins in Experimental Autoimmune Encephalomyelitis Model and Cuprizone-Induced Demyelination Model by Olink Proteomics
Study Overview This research investigates protein alterations in the cerebrospinal fluid (CSF) using two distinct models of demyelination: Experimental Autoimmune
Compromised blood-brain barrier in traumatic brain injury model of Danio rerio: A unique window to demonstrate restoration of behavioral, cellular, and neurochemical deficits by limonin
Study Overview This research focuses on the effects of traumatic brain injury (TBI) and the consequential disruption of the blood-brain
Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia
Pathophysiological Mechanisms The pathophysiology underlying Purkinje cell-specific disruptions in neurofascin and ankyrin G reveals critical insights into the mechanisms that
Case Report: Transverse myelitis following CAR-T cell therapy for post-transplant lymphoproliferative disorder
Study Overview This case report investigates the occurrence of transverse myelitis in a patient who underwent CAR-T (Chimeric Antigen Receptor
PPARγ activation by leriglitazone counteracts neurodegeneration and neuroinflammation in a disease-relevant mouse model of COASY dysfunction
Study Overview The research focuses on the therapeutic effects of leriglitazone, a PPARγ (peroxisome proliferator-activated receptor gamma) agonist, in a
The Crossroads of Neuroinflammation and Biomarkers in Multiple Sclerosis: A Systematic Review
Neuroinflammation Mechanisms Neuroinflammation is a complex biological response characterized by the activation of the immune system within the central nervous