Association with Tau Pathology The study examines the relationship between soluble tumor necrosis factor receptor 1 (sTNFR1) levels and tau […]
Study Overview The research focuses on the role of Snapin, a protein that contributes to neuronal PANoptosis, following mild traumatic
Study Overview The research focuses on the role of GASDERMIN D in the context of pyroptosis within a mouse model
Research Context The brain is a complex organ with numerous cellular interactions, and understanding these dynamics is critical for addressing
Impact of Oxidative Stress Oxidative stress is a condition characterized by an imbalance between the production of reactive oxygen species
Study Overview The research investigates the utilization of advanced brain organoid platforms to explore the impacts of traumatic brain injury
Neuronal Endoplasmic Reticulum Stress and Apoptosis The endoplasmic reticulum (ER) plays a crucial role in maintaining cellular homeostasis by facilitating
Role of Lactate Metabolism in Astrocytes Lactate metabolism plays a pivotal role in cellular energy production and homeostasis, particularly in
Pathological Tau Phosphorylation Mechanisms Tau protein is a key player in maintaining the structural integrity of neurons. Its primary role
Astrocytes, traditionally viewed as mere support cells, play a pivotal role in the development of post-traumatic epileptogenesis (PTE). They are involved in maintaining ionic homeostasis, the integrity of the blood-brain barrier, neurotransmitter metabolism, and neuronal energy supply. Furthermore, astrocytes are instrumental in modulating neuronal activity, including the exchange of neuronal pyruvate for astrocytic lactate, which enhances neuronal metabolism. They also participate in synaptic information processing by modulating neurotransmitter uptake and release. The activation of astrocytes, a key component of the neuroinflammatory response to traumatic brain injury (TBI), contributes significantly to the pathophysiology of PTE. Astrocytes respond to axonal degeneration, neuronal cell death, and the release of inflammatory factors, which can alter their physiological functioning and impact epileptogenesis. Studies have shown functional changes in astrocytes in epileptic conditions, such as reduced potassium currents and altered gap junction coupling, which are key factors in the development of epilepsy.
Understanding the Pathophysiology of Post-Traumatic Epilepsy Read Post »
