Tag:

neuronal cell death

Traumatic brain injury
Ferroptosis-Mediated Hippocampal Neuronal Loss Post-mTBI: Chromatin Accessibility Profiling and Single-Nucleus Transcriptomics

by myneuronews December 15, 2025

by myneuronews December 15, 2025

Research Context The brain is a complex organ with numerous cellular interactions, and understanding these …

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Traumatic brain injury
Influence of oxidative stress caused by a blast wave in acoustic barotrauma on the auditory analyzer

by myneuronews August 23, 2025

by myneuronews August 23, 2025

Impact of Oxidative Stress Oxidative stress is a condition characterized by an imbalance between the …

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Traumatic brain injury
Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Study Overview The research investigates the utilization of advanced brain organoid platforms to explore the …

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Traumatic brain injury
Cannabidiol inhibits neuronal endoplasmic reticulum stress and apoptosis in rats with multiple concussions by regulating the PERK-eIF2alpha-ATF4-CHOP pathway

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Neuronal Endoplasmic Reticulum Stress and Apoptosis The endoplasmic reticulum (ER) plays a crucial role in …

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Functional neurological disorders
Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Loss of CD98HC Phosphorylation and Its Consequences Recent research has highlighted the significant role of …

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Traumatic brain injury
Single-Cell RNA and Transcriptome Sequencing to Analyze the Role of Lactate Metabolism in Traumatic Brain Injury Astrocytes

by myneuronews May 21, 2025

by myneuronews May 21, 2025

Role of Lactate Metabolism in Astrocytes Lactate metabolism plays a pivotal role in cellular energy …

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Traumatic brain injury
Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

by myneuronews May 10, 2025

by myneuronews May 10, 2025

Pathological Tau Phosphorylation Mechanisms Tau protein is a key player in maintaining the structural integrity …

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Medical professionals Post traumatic epilepsy Traumatic brain injury
Understanding the Pathophysiology of Post-Traumatic Epilepsy

by Ioannis Mavroudis February 14, 2024

by Ioannis Mavroudis February 14, 2024

Astrocytes, traditionally viewed as mere support cells, play a pivotal role in the development of …

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Platforms to Evaluate Flavivirus-Induced Immunoinflammatory Responses and Their Pathogenesis
Overview of Flavivirus Pathogenesis Flaviviruses, a diverse group of RNA viruses, are known to cause…
Comparative Assessment of Mental and Cognitive Status
Assessment Framework The evaluation of mental and cognitive status relies on a structured framework that…
How Developing Brains Differ: Pediatric Functional Neurological Disorder: Distinct Clinical Courses, Unique Needs, Personalized Communication, and Pathways to Recovery
Understanding Pediatric Functional Neurological Disorder Pediatric Functional Neurological Disorder (pFND) refers to a condition where…
Somatic symptom and related disorders in the Arab world: a narrative review of clinical features and care implications
Clinical Features of Somatic Symptom Disorders Somatic symptom disorders encompass a diverse range of clinical…
Reclaiming Functional Neurological Disorder for Rehabilitation Medicine
Understanding Functional Neurological Disorder Functional Neurological Disorder (FND) is a complex condition characterized by neurological…

Enhancing Outpatient Clinic Recruitment: A Quality Improvement Strategy for a Prospective Research Study
CONCLUSIONS: This project demonstrates the successful application of quality improvement methodology toward optimizing clinical recruitment. Approaches used in this study can potentially be generalized to other outpatient clinical populations and research studies.
Driving After Concussion: Clinical Measures Associated With Postconcussion Driving
CONCLUSIONS: Dual-task and Complex Figure tests might be useful when assessing postconcussion driving ability. Higher VOMS symptom provocation was associated with better driving performance, possibly indicating that individuals experiencing vestibular-oculomotor symptoms may adopt more cautious strategies.
Health Literacy Among Adolescent Athletes Across Rural and Urban Communities and Evaluating Scores Aside State-Mandated Concussion Education
CONCLUSIONS: Urban adolescent athletes had better health literacy compared with their rural peers; however, irrespective of rurality, more than half of participants had low health literacy for their appropriate age/grade in high school (≤seventh grade). Ensuring that health information is provided at an appropriate reading level for the target audience is essential to increasing health […]
Effectiveness of intensive exposure therapy for persistent post-concussion symptoms: an aggregated single-case design approach
The fear-avoidance model suggests that catastrophising and avoidance behaviours can maintain persistent post-concussion symptoms (PPCS) after mild traumatic brain injury (mTBI). Although exposure therapy has shown preliminary success in this population, its effectiveness in mTBI remains unproven. This study investigated the therapeutic effects of this therapy across different settings. Twenty participants with PPCS took part […]
Plasma biomarkers in chronic mild traumatic brain injury: A review
Background/Objective: Understanding the biological cascade which results from a mild traumatic brain injury (mTBI) is essential to determine outcomes over time. Acute plasma levels of brain-related injury markers (BRIMS; ubiquitin carboxy-terminal hydrolase L1 [UCH-L1], total tau[t-tau], neurofilament light chain [NfL], S100 calcium-binding protein β [S100β], glial fibrillary acidic protein [GFAP]) are typically elevated in patients […]