Tag:

neuronal damage

Dementia
Divergent and convergent TMEM106B pathology in murine models of neurodegeneration and human disease

by myneuronews August 9, 2025

by myneuronews August 9, 2025

Pathological Roles of Tmem106b in Neurodegeneration The involvement of TMEM106B in neurodegenerative diseases is a …

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Traumatic brain injury
Vibrational spectroscopy methods reveal biochemical changes associated with the glial scar formation after traumatic brain injury

by myneuronews August 9, 2025

by myneuronews August 9, 2025

Biochemical Changes During Glial Scar Formation After a traumatic brain injury (TBI), the brain undergoes …

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Traumatic brain injury
Letter: Mild Traumatic Brain Injury in Older Adults: Recovery Course and Insights on Early Predictors of Outcome

by myneuronews August 8, 2025

by myneuronews August 8, 2025

Recovery Patterns in Older Adults The recovery patterns following mild traumatic brain injury (mTBI) in …

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Traumatic brain injury
Development of a modified weight-drop apparatus for closed-skull, repetitive mild traumatic brain injuries in a mouse model

by myneuronews August 6, 2025

by myneuronews August 6, 2025

Study Overview The research focuses on the development of a specialized apparatus designed to replicate …

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Functional neurological disorders
AAV-based gene therapy ameliorates neurological deficits in a mouse model of childhood-onset neurodegeneration with cerebellar atrophy (CONDCA)

by myneuronews August 4, 2025

by myneuronews August 4, 2025

Study Summary The study investigates the efficacy of adeno-associated virus (AAV)-based gene therapy in a …

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Dementia
Embracing the Modern Biochemistry of Brain Metabolism

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Understanding Brain Metabolism The brain is an extraordinarily energy-demanding organ, consuming approximately 20% of the …

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Traumatic brain injury
Neurobiology and Impact of Chronic Traumatic Encephalopathy in Athletes: A Focused Review

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Neurobiological Mechanisms Chronic Traumatic Encephalopathy (CTE) is a progressive neurodegenerative disease primarily associated with repeated …

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Functional neurological disorders
Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease

by myneuronews July 21, 2025

by myneuronews July 21, 2025

Integrated Transcriptomic Approaches The integration of transcriptomic approaches offers a powerful way to glean insights …

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Traumatic brain injury
Inhibition of microglia priming by NLRP3 reduces the impact of early life stress and mild TBI

by myneuronews July 17, 2025

by myneuronews July 17, 2025

Study Overview The objective of the research was to investigate how inhibiting the activation of …

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Functional neurological disorders
Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Luminal Glycocalyx and Its Role in Blood Brain Barrier Integrity The luminal glycocalyx is a …

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Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience
Clinical Characteristics Cerebral Amyloid Angiopathy-Related Inflammation (CAA-RI) manifests through a variety of clinical symptoms that…
Collaborative Community Support for People Impacted by Dementia: A Social Return on Investment Analysis
Study Overview This research focuses on understanding the impact of a community-based support program designed…
A cognitive energy crisis: A systematic review & meta-analysis of effective interventions for pediatric cognitive fatigue post-acquired brain injury
Cognitive Fatigue in Pediatric Populations Cognitive fatigue is a significant concern in pediatric populations, particularly…
Investigating the Role of Gut-Derived Neurotoxin TMAO in PTSD Risk Following Traumatic Brain Injury
Study Overview This research investigates the connection between gut-derived neurotoxin trimethylamine N-oxide (TMAO) and the…
ENIGMA’s advanced guide for parcellation error identification (EAGLE-I): An implementation in the context of brain lesions
Study Overview The study focuses on enhancing the accuracy of brain lesion parcellation, a crucial…

Substrate-selective COX-2 inhibition by IMMA attenuates posttraumatic headache via endocannabinoid modulation and neuroinflammatory suppression
CONCLUSION: IMMA effectively attenuates neuroinflammation and pain hypersensitivity in the acute phase of PTH through a distinct mechanism that preserves endocannabinoid tone without suppressing physiological prostaglandins. While these results highlight its promise as a novel therapeutic strategy, further studies are warranted to determine its efficacy during the chronic phase of PTH and across anatomically targeted […]
A cognitive energy crisis: A systematic review & meta-analysis of effective interventions for pediatric cognitive fatigue post-acquired brain injury
Acquired Brain Injuries (ABIs) cause long-term disruption to young individuals' development. Persistent cognitive fatigue is a commonly reported sequela following pediatric ABI. Currently, there are no evidence-based interventions targeting cognitive fatigue post-ABI amongst pediatric patients. The current systematic review and meta-analysis aimed to review research on the efficacy of pharmacological and non-pharmacological interventions for cognitive […]
Investigating the Role of Gut-Derived Neurotoxin TMAO in PTSD Risk Following Traumatic Brain Injury
CONCLUSION: Serum TMAO levels were significantly elevated in PTSD patients comorbid with TBI and were closely associated with PTSD severity. Furthermore, TMAO may aid in the early identification of high-risk, severe PTSD patients following TBI, thus helping to optimize intervention strategies.
ENIGMA's advanced guide for parcellation error identification (EAGLE-I): An implementation in the context of brain lesions
Cortical parcellation is a critical step in several neuroimaging pipelines, yet even in high quality images without pathology, errors are common. For patients with moderate to severe traumatic brain injury (ms-TBI), typical parcellation errors can be exacerbated by focal pathology impacting cortical regions. Careful visual quality checking (QC) of parcellation images of ms-TBI patients should […]
Knowledge and attitudes of concussion and chronic traumatic encephalopathy amongst a sample of non-professional rugby players
CONCLUSIONS: Non-professional rugby players are generally knowledgeable about concussion. However, some gaps in their knowledge relating to coma and the course of symptoms of concussion were identified. Unsafe attitudes, particularly among school players, need to be addressed. Non-professional rugby players are interested in further education about CTE.