Roles of Metformin and Pioglitazone in Regulating A1-like Astrocyte Activation in EAE Mice
Study Overview This investigation centers on the roles of two pharmacological agents, Metformin and Pioglitazone, in modulating the activation state […]
Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia
Pathophysiological Mechanisms The pathophysiology underlying Purkinje cell-specific disruptions in neurofascin and ankyrin G reveals critical insights into the mechanisms that
Raloxifene Beyond Osteoporosis: Unlocking Neurorestoration Through Remyelination, Inflammatory Regulation, and Neuroimmune Modulation in CNS Pathologies
Therapeutic Mechanisms of Raloxifene Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits unique therapeutic mechanisms, particularly in the
Biomarkers for acute mild brain injury (BAMBI): optimising GFAP/UCH-L1 thresholds to support CT stewardship in a NICE-guided mild-traumatic-brain-injury cohort
Study Overview This research aimed to identify and optimize the threshold levels of two specific biomarkers, GFAP (glial fibrillary acidic
Evaluation of brain injury biomarkers in mild traumatic brain injury with and without computed tomography findings
Study Overview In recent years, the assessment of mild traumatic brain injury (mTBI) has become increasingly significant due to its
Relevance of serum neurofilament light chain determination as a biomarker in multiple sclerosis. Consensus of the Spanish Society of Neurology’s Study Group on Multiple Sclerosis and Related Neuroimmune Diseases
Relevance of Neurofilament Light Chain Neurofilament light chain (NfL) plays a crucial role in the assessment of neurodegenerative diseases, including
Reversal of Endogenous Bioelectrical Network Collapse in Advanced Childhood Cerebral X-Linked Adrenoleukodystrophy
Study Overview This study investigates the catastrophic decline of the endogenous bioelectrical network in patients with advanced forms of childhood
Blast Exposure Does Not Increase Blood Biomarkers of Neurodegeneration in Service Members and Veterans with and Without Uncomplicated Mild TBI
Study Overview The research investigates the relationship between blast exposure and neurodegeneration biomarkers in military personnel, specifically focusing on service
Microglial PD-1/PD-L1 axis in CNS demyelinating diseases: a dual immunoregulatory perspective
Microglial Function in CNS Demyelination Microglia are specialized immune cells residing in the central nervous system (CNS) and play a
Insights From Quantitative Susceptibility Mapping: An Umbrella Review of Multiple Sclerosis
Study Overview The article focuses on the innovative use of quantitative susceptibility mapping (QSM) as a diagnostic and research tool