Glial Heme Oxygenase-1 Regulates Neuroinflammation and Cerebrovascular Function After Mild Traumatic Brain Injury
Role of Heme Oxygenase-1 in Neuroinflammation Heme oxygenase-1 (HO-1) is an enzyme that plays a crucial role in the breakdown […]
Multiple sclerosis as an asynchronous neuroinflammatory system
Neuroinflammatory Mechanisms Multiple sclerosis (MS) is characterized by complex neuroinflammatory processes that contribute to its pathophysiology. Central to MS is
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Loss of TREM2 is associated with altered microglial responses and inhibitory synaptic changes after closed head injury
Microglial Response Alterations The brain’s immune cells, known as microglia, play a crucial role in maintaining the health of the
PERK deficiency amplifies molecular, structural, and network vulnerability to repetitive mild traumatic brain injury
Molecular Mechanisms of PERK Deficiency The deficiency of Protein kinase-like endoplasmic reticulum kinase (PERK) fundamentally alters cellular functions, primarily through
Brain targeting and trafficking of extracellular vesicles in central nervous system diseases: a therapeutic roadmap
Extracellular Vesicles in CNS Diseases Extracellular vesicles (EVs) are small, membrane-bound structures released by cells that play a significant role
Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Spinal Cord Injury: From Molecular Repair Mechanisms to Standardized Translational Development
Background on Extracellular Vesicles Extracellular vesicles (EVs) represent a complex and versatile mode of intercellular communication, playing pivotal roles in
Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Spinal Cord Injury: From Molecular Repair Mechanisms to Standardized Translational Development
Study Overview The research focuses on the potential of small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) as
Therapeutic Hypothermia for Neurological Injuries: Balancing Neuroprotection with Risks
Therapeutic Hypothermia Mechanisms Therapeutic hypothermia involves lowering a patient’s body temperature to mitigate the effects of neurological injuries such as
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Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation
Microenvironment Characterization The cribriform plate, a structure located at the base of the skull, plays a significant role in the
Therapeutic Hypothermia for Neurological Injuries: Balancing Neuroprotection with Risks
Therapeutic Hypothermia Mechanisms Therapeutic hypothermia, often utilized in clinical settings for neuroprotection, operates through several key biological mechanisms. The primary
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