ISG15/ISGylation in central nervous system diseases: molecular mechanisms and therapeutic targeting
Molecular Mechanisms of ISG15/ISGylation ISG15, or interferon-stimulated gene 15, is a small ubiquitin-like modifier that plays a crucial role in […]
ISG15/ISGylation in central nervous system diseases: molecular mechanisms and therapeutic targeting
Mechanisms of ISG15/ISGylation ISG15, or Interferon-Stimulated Gene 15, plays a crucial role in the immune response and cellular mechanisms, particularly
Nitric oxide and traumatic brain injury
Nitric Oxide Mechanisms in Brain Injury Nitric oxide (NO) plays a crucial role in the pathophysiology of traumatic brain injury
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Do apelin and ghrelin play a role in multiple sclerosis? The analysis of patients treated with immunomodulatory therapies
Study overview The research focused on examining the roles of apelin and ghrelin, two peptides with potential implications in metabolic
GV1001: repurposing a telomerase-derived peptide for neurological therapeutics
Peptide Mechanism of Action The peptide derived from telomerase exhibits a unique mechanism that appears to interact with various biological
GV1001: repurposing a telomerase-derived peptide for neurological therapeutics Read Post »
Sport-related trauma and motor neurone disease: a scoping review of epidemiology, mechanisms and future directions
Epidemiology of Sport-related Trauma The prevalence of sport-related trauma has emerged as a significant public health concern, particularly in contact
Investigations of remibrutinib in models pertinent to multiple sclerosis
Study Overview The investigation focused on remibrutinib, a selective Bruton’s tyrosine kinase (BTK) inhibitor, and its potential applications in treating
Investigations of remibrutinib in models pertinent to multiple sclerosis Read Post »
Adjunctive Non-Disease-Modifying Therapies in Multiple Sclerosis: Immunometabolic, Neuroprotective and Remyelination-Oriented Approaches
Overview of Adjunctive Therapies Adjunctive therapies in multiple sclerosis (MS) encompass a range of non-disease-modifying treatments that aim to alleviate
Restoring mitochondrial health after blast-induced traumatic brain injury: modifiable factors and therapeutic opportunities
Mitochondrial Dysfunction in Traumatic Brain Injury Mitochondria, often referred to as the powerhouse of the cell, play a crucial role
Ceftriaxone has a similar effect on astrocytic and neuronal GLT-1 distribution after mild traumatic brain injury
Study Overview The research investigates the effects of Ceftriaxone, an antibiotic known for its potential neuroprotective properties, on the distribution