Tag:

pathophysiology

Headaches
Long-term outcomes in leucine-rich glioma inactivated-1 autoimmune encephalitis and associated biomarkers of inflammation and neuronal and glial injury

by myneuronews June 5, 2025

by myneuronews June 5, 2025

Long-term outcomes Long-term outcomes in patients with leucine-rich glioma inactivated-1 (LGI1) autoimmune encephalitis are a …

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Functional neurological disorders
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

by myneuronews June 5, 2025

by myneuronews June 5, 2025

Humanized Antibody Development The creation of humanized antibodies involves a sophisticated process that aims to …

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Movement Disorders
[18F]FE-PE2I PET is a diagnostic tool in dementia with Lewy bodies

by myneuronews June 3, 2025

by myneuronews June 3, 2025

Diagnostic Efficacy The application of 18F]FE-PE2I PET imaging has shown promise as a valuable diagnostic …

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Headaches
Comparative Analysis of CGRP, VIP and  PACAP-38 Levels in Migraine with and  Without Aura: A Case-control Study

by myneuronews June 3, 2025

by myneuronews June 3, 2025

Study Overview This research investigates the levels of three neuropeptides—CGRP (Calcitonin Gene-Related Peptide), VIP (Vasoactive …

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Functional neurological disorders
Alterations in Cortical Microstructure, Morphology, and Intrinsic Local Function in Spiking Tissue in Patients With Focal Epilepsy

by myneuronews June 3, 2025

by myneuronews June 3, 2025

Cortical Microstructure Alterations Cortical microstructure alterations in individuals with focal epilepsy involve complex changes in …

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Functional neurological disorders
Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Loss of CD98HC Phosphorylation and Its Consequences Recent research has highlighted the significant role of …

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Traumatic brain injury
Global trends and psychosocial effects of traumatic brain injury: A bibliometric and machine learning analysis

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Global Trends in Traumatic Brain Injury The incidence of traumatic brain injury (TBI) has emerged …

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Functional neurological disorders
Microglia-drive IRF8 upregulates complement pathway in Parkinson’s disease

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Microglia and Parkinson’s Disease Microglia, the resident immune cells of the brain, play a crucial …

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Functional neurological disorders
Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Loss of CD98HC Phosphorylation and Its Consequences The study highlights the significant role of CD98HC …

Read more

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Functional neurological disorders
Microglia-drive IRF8 upregulates complement pathway in Parkinson’s disease

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Microglia and Parkinson’s Disease Pathophysiology Microglia, the resident immune cells of the central nervous system, …

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Understanding factors influencing the return to physical activity, perspectives of adults with concussion/mild traumatic brain injury: A qualitative study
Understanding the factors that influence the return to physical activity can help to modify behaviour to enhance the recovery of symptoms and physical activity. We conducted 14 semi-structured interviews to explore the barriers and facilitators to returning to physical activity in adults following a mild traumatic brain injury (TBI). The study design was informed by […]
Persistent Post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies
INTRODUCTION: Persistent post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI) represents a growing global health challenge that significantly impacts patients' quality of life. Despite advances in acute concussion management, there remains a critical need for effective, evidence-based treatments for chronic PCS, as current interventions show limited success in addressing both symptoms and underlying pathophysiology.
Time-limited association between plasma transfusion and mortality in pediatric traumatic brain injury
CONCLUSION: This study reports a significant association between early plasma administration and a lower risk of 4-hour mortality among children with severe TBI that does not persist at or beyond 24 hours. While these data suggest that plasma resuscitation may extend the window for lifesaving intervention, additional prospective data are needed.
Comparing the sensitivity and specificity of novel motor assessments for traumatic brain injury
CONCLUSION: MMC-mediated tests are sensitive and specific (compared to traditional clinical tests) and have potential to fill a gap in clinical care of TBI.
Cellular mechanisms of traumatic brain injury
Mild traumatic brain injury (mTBI) is an acute injury with immediate and medium-term symptom presentation. However, our mechanistic understanding of mTBI and how mechanical loading of soft cellular tissues leads to injury is limited. The aim of this review is to introduce this interdisciplinary field to non-experts and provide an overview of our current understanding […]