Tag:

pathophysiology

Functional neurological disorders
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

by myneuronews June 5, 2025

by myneuronews June 5, 2025

Humanized Antibody Development The creation of humanized antibodies involves a sophisticated process that aims to …

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Functional neurological disorders
Development and in vitro characterization of humanized antibodies for blocking human TRPM4 channel

by myneuronews June 5, 2025

by myneuronews June 5, 2025

Background on TRPM4 Channel The TRPM4 channel, a member of the transient receptor potential (TRP) …

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Headaches
Comparative Analysis of CGRP, VIP and  PACAP-38 Levels in Migraine with and  Without Aura: A Case-control Study

by myneuronews June 3, 2025

by myneuronews June 3, 2025

Study Overview This research investigates the levels of three neuropeptides—CGRP (Calcitonin Gene-Related Peptide), VIP (Vasoactive …

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Functional neurological disorders
Alterations in Cortical Microstructure, Morphology, and Intrinsic Local Function in Spiking Tissue in Patients With Focal Epilepsy

by myneuronews June 3, 2025

by myneuronews June 3, 2025

Cortical Microstructure Alterations Cortical microstructure alterations in individuals with focal epilepsy involve complex changes in …

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Functional neurological disorders
Alterations in Cortical Microstructure, Morphology, and Intrinsic Local Function in Spiking Tissue in Patients With Focal Epilepsy

by myneuronews June 3, 2025

by myneuronews June 3, 2025

Cortical Microstructure Alterations Recent investigations into the brains of patients with focal epilepsy have revealed …

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Functional neurological disorders
Microglia-drive IRF8 upregulates complement pathway in Parkinson’s disease

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Microglia and Parkinson’s Disease Microglia are the primary immune cells of the central nervous system, …

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Functional neurological disorders
Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Loss of CD98HC Phosphorylation and Its Consequences Recent research has highlighted the significant role of …

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Traumatic brain injury
Global trends and psychosocial effects of traumatic brain injury: A bibliometric and machine learning analysis

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Global Trends in Traumatic Brain Injury The incidence of traumatic brain injury (TBI) has emerged …

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Functional neurological disorders
Microglia-drive IRF8 upregulates complement pathway in Parkinson’s disease

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Microglia and Parkinson’s Disease Microglia, the resident immune cells of the brain, play a crucial …

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Functional neurological disorders
Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia

by myneuronews June 2, 2025

by myneuronews June 2, 2025

Loss of CD98HC Phosphorylation and Its Consequences The study highlights the significant role of CD98HC …

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<em>Taking Control of Your Functional Cognitive Symptoms: Workbook</em>-A Novel Intervention
CONCLUSIONS: This promising new multimodality behavioral health intervention can be considered to be in stage 1 (i.e., intervention generation, refinement, modification, adaptation, and pilot testing). Further pilot testing is being conducted and will need to be followed by traditional efficacy testing (in stage 2).
Hemodynamic Oscillations in Mild TBI During Postural Change: An fNIRS Pilot Study
We demonstrate that low-frequency oscillations (LFOs) in cerebral hemodynamics, measured by frequency-domain functional near-infrared spectroscopy (FD-fNIRS), reflect altered cerebral hemodynamic oscillations in mild traumatic brain injury (mTBI). In a pilot study of two mTBI and 13 healthy subjects undergoing head-of-bed positional changes, we analyzed total hemoglobin concentration (THC), oxyhemoglobin (HbO), and deoxyhemoglobin (Hb) dynamics using […]
Psychometrics of a fear-avoidance measure adapted for youth with persistent postconcussive symptoms: Fear of Concussive Symptoms Questionnaire (FOCSQ) child and parent-proxy versions
CONCLUSIONS: The FOCSQ is a reliable and valid measure of fear-avoidance in youth with concussion, and future research might explore whether this measure could be used to identify youth at risk for prolonged recovery. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Differences in narrative discourse ability in traumatic brain injury and a neurotypical comparison group: Influence of age, education, and sex
CONCLUSIONS: TBI disrupts both narrative discourse comprehension and production ability. Findings underscore the need to evaluate both narrative comprehension and production performance following TBI. Age, education, and sex did not influence discourse outcomes.
Influence of traumatic brain injury on serum levels of pituitary, thyroid, adrenal and gonadal hormones
This study explores the clinical significance of dynamic changes in pituitary, thyroid, adrenal and gonadal hormones following traumatic brain injury (TBI). The study cohort included 90 patients with mild, moderate, or severe TBI and 30 healthy volunteers as the control group. Serum levels of total triiodothyronine (TT3), thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), […]