Tag:

pathophysiology

Functional neurological disorders
Expanding the spectrum of ATP8A2 mutations: a new splicing variant and systematic review of CAMRQ4 syndrome

by myneuronews May 1, 2025

by myneuronews May 1, 2025

Identifying New ATP8A2 Mutations ATP8A2 mutations have garnered significant attention in recent years due to …

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Functional neurological disorders
Expanding the spectrum of ATP8A2 mutations: a new splicing variant and systematic review of CAMRQ4 syndrome

by myneuronews May 1, 2025

by myneuronews May 1, 2025

Overview of ATP8A2 and CAMRQ4 Syndrome ATP8A2 is a gene that encodes a protein crucial …

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Traumatic brain injury
PACAP a mediator of inflammation following trauma exposure and mild traumatic brain injury: Differential effects in males and females

by myneuronews May 1, 2025

by myneuronews May 1, 2025

Overview of PACAP and Inflammation Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that plays …

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Functional neurological disorders
Mechanical stress contributes to ligamentum flavum hypertrophy by inducing local inflammation and myofibroblast transition in the innovative surgical rabbit model

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Mechanisms of Ligamentum Flavum Hypertrophy The study delves into the complex changes that occur in …

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Functional neurological disorders
Autoimmune psychosis: Psychopathological patterns and outcome after immunotherapy

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Autoimmune Psychosis Overview Autoimmune psychosis is an emerging area of interest in neurology and psychiatry, …

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Functional neurological disorders
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Microglia Replacement Strategy The study introduces an innovative approach to addressing neurological disorders through the …

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Headaches
Efficacy, safety, and tolerability of chenodeoxycholic acid (CDCA) in adult patients with cerebrotendinous xanthomatosis (RESTORE): a randomized withdrawal, double-blind, placebo-controlled, crossover phase 3 study

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Efficacy of Chenodeoxycholic Acid Chenodeoxycholic acid (CDCA) has emerged as a critical therapeutic option for …

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Functional neurological disorders
Silencer variants are key drivers of gene upregulation in Alzheimer’s disease

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Silencer Variants and Gene Regulation Recent advancements in genetic research have shed light on the …

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Traumatic brain injury
Retinal manifestations of traumatic brain injury

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Retinal Changes Associated with Traumatic Brain Injury Traumatic brain injury (TBI) can lead to various …

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Traumatic brain injury
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Study Overview The research undertaken aimed to establish a reliable and straightforward model of mild …

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Discipline-specific responses to a complex migraine case: a vignette-based survey among neurologists, psychiatrists, and family physicians
Study Overview The investigation aimed to explore the variations in clinical responses to a complex…
Differences in inflammatory markers, mitochondrial function, and synaptic proteins in male and female Alzheimer’s disease post mortem brains
Inflammatory Markers Comparison Research into Alzheimer’s disease has increasingly highlighted the significance of inflammation in…
Propofol Exposure Precipitating a Functional Movement Disorder: A Case Report
Propofol’s Role in Functional Movement Disorders Propofol, a widely used intravenous anesthetic, is renowned for…
Functional left hemiparesis
Overview of Functional Left Hemiparesis Functional left hemiparesis is a type of movement disorder characterized…
Blocking axon-glial mechanotransduction to prevent concussive brain injury
Study Overview The research focuses on preventing concussive brain injuries through the inhibition of mechanotransduction…

Psychometrics of a fear-avoidance measure adapted for youth with persistent postconcussive symptoms: Fear of Concussive Symptoms Questionnaire (FOCSQ) child and parent-proxy versions
CONCLUSIONS: The FOCSQ is a reliable and valid measure of fear-avoidance in youth with concussion, and future research might explore whether this measure could be used to identify youth at risk for prolonged recovery. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Differences in narrative discourse ability in traumatic brain injury and a neurotypical comparison group: Influence of age, education, and sex
CONCLUSIONS: TBI disrupts both narrative discourse comprehension and production ability. Findings underscore the need to evaluate both narrative comprehension and production performance following TBI. Age, education, and sex did not influence discourse outcomes.
Influence of traumatic brain injury on serum levels of pituitary, thyroid, adrenal and gonadal hormones
This study explores the clinical significance of dynamic changes in pituitary, thyroid, adrenal and gonadal hormones following traumatic brain injury (TBI). The study cohort included 90 patients with mild, moderate, or severe TBI and 30 healthy volunteers as the control group. Serum levels of total triiodothyronine (TT3), thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), […]
Neural oscillation mechanisms of repetitive subconcussive impacts: a network study of microstate-specific cross-frequency coupling
CONCLUSIONS: SC exposure induces MCFCNs abnormalities resembling central pain syndromes, even in the absence of overt symptoms. These findings suggest that interactions within MCFCNs may serve as potential early biomarkers for headache vulnerability and chronicity, warranting further exploration in longitudinal studies and targeted neurointerventions.
Impact of > 24 h sustained wakefulness and subsequent recovery sleep on time-dependent changes in microRNA factors of individuals with post-acute phase mild traumatic brain injury
INTRODUCTION: The purpose of the present study was to determine whether mild traumatic brain injury (mTBI+) results in latent changes in microRNA expression profiles across an episode of total sleep deprivation (TSD).