Muscle Wasting in Diabetes: A Case Report Evaluating a Rare Neuropathic Complication of Diabetic Microvasculitis
Study Overview This article presents a comprehensive analysis of a rare case encountered in clinical practice where a patient with […]
Two Novel Variants in MT-RNR1 Gene Associated with Hereditary Optic Neuropathy: A Case Report
Study Overview Hereditary optic neuropathy comprises a group of genetic disorders characterized by the degeneration of retinal ganglion cells, leading
The Role of Cytokines in Traumatic Brain Injury
Impact of Cytokines on Neuroinflammation Cytokines play a pivotal role in the immune response of the central nervous system, particularly
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Dissecting NMOSD pathogenesis through animal models: a mechanism-oriented systems perspective
Mechanistic Insights into NMOSD Neuromyelitis Optica Spectrum Disorder (NMOSD) is a complex autoimmune condition that primarily affects the central nervous
An unrecognized mechanism of neuroprotection by microglial TIA1-mediated stress granules to prevent neuroinflammation and demyelination in experimental autoimmune encephalomyelitis mice through sequestering ApoE mRNA
Mechanism of TIA1-Mediated Neuroprotection The immune response in the central nervous system (CNS) plays a critical role in maintaining homeostasis
The gut microbiome in pediatric-onset acquired demyelinating syndromes by myelin oligodendrocyte glycoprotein antibody status
Study overview This research investigates the role of the gut microbiome in pediatric patients who develop acquired demyelinating syndromes (ADS),
Abnormal Expression of Suppressor of Cytokine Signalling (SOCS) Molecules Contributes to the Development of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Mechanisms of SOCS Molecules in MS The suppressor of cytokine signaling (SOCS) proteins play a pivotal role in modulating immune
Pediatric SARS-CoV-2 outcomes study (PECOS): 12-month longitudinal analysis of post-COVID symptoms in infected versus uninfected participants
Study Design and Participants The study employed a longitudinal design, focusing on children and adolescents aged 0 to 18 who
Spleen-brain axis regulates myelin integrity via TGF-beta1 signaling in cuprizone-induced demyelination and remyelination model
Spleen-brain axis and myelin integrity The connection between the spleen and brain is a crucial aspect of the immune system’s
Dual role of Ninjurin-1 in myeloid cell adhesion and inflammation in relapse-remitting EAE
Study Overview The investigation focused on understanding the dual functions of Ninjurin-1, a cell adhesion molecule, particularly in the context