Tag:

pathophysiology

Functional neurological disorders
The role of immunotherapy in a refractory case of acute hemorrhagic leukoencephalitis in a pediatric patient

by myneuronews May 16, 2025

by myneuronews May 16, 2025

Clinical Presentation and Diagnosis In evaluating a pediatric patient presenting with acute hemorrhagic leukoencephalitis (AHLE), …

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Functional neurological disorders
Unveiling diverse clinical symptom patterns and neural activity profiles in major depressive disorder subtypes

by myneuronews May 16, 2025

by myneuronews May 16, 2025

Clinical Symptom Patterns in Major Depressive Disorder In the realm of mental health, Major Depressive …

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Headaches
Neurological complications of orthopoxvirus infections: neurotropism and neurovirulence

by myneuronews May 15, 2025

by myneuronews May 15, 2025

Neurological Manifestations in Orthopoxvirus Infection Orthopoxvirus infections are associated with a variety of neurological manifestations …

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Stroke
Olfaction and Plasma Biomarkers of Alzheimer Disease and Neurodegeneration in the Atherosclerosis Risk in Communities Study

by myneuronews May 15, 2025

by myneuronews May 15, 2025

Study Overview The research focused on the relationship between olfactory function and Alzheimer’s disease (AD), …

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Traumatic brain injury
Sensory driven neurophysiological mechanisms of concussion: a parsimonious and falsifiable theory

by myneuronews May 15, 2025

by myneuronews May 15, 2025

Overview of Neurophysiological Mechanisms Understanding the neurophysiological mechanisms underlying concussion involves delving into the complex …

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Functional neurological disorders
Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease

by myneuronews May 14, 2025

by myneuronews May 14, 2025

Association of Apoc1 with Alzheimer’s Disease Recent research has underscored the significance of the apolipoprotein …

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Functional neurological disorders
DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function

by myneuronews May 14, 2025

by myneuronews May 14, 2025

Mechanisms of DG9 Action DG9 has emerged as a pivotal compound in the realm of …

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Movement Disorders
Safety and tolerability of intravenous liposomal GM1 in patients with Parkinson disease: A single-center open-label clinical phase I trial (NEON trial)

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Study Overview The study aimed to investigate the safety and tolerability of intravenous liposomal GM1 …

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Functional neurological disorders
Research Progress on BDNF and Depression

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Understanding BDNF in Depression Brain-Derived Neurotrophic Factor (BDNF) is a crucial protein that supports the …

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Dementia
Validating the Amyloid Cascade Through the Revised Criteria of Alzheimer’s Association Workgroup 2024 for Alzheimer Disease

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Amyloid Cascade Hypothesis and Alzheimer Disease The Amyloid Cascade Hypothesis is a prominent concept in …

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Understanding factors influencing the return to physical activity, perspectives of adults with concussion/mild traumatic brain injury: A qualitative study
Understanding the factors that influence the return to physical activity can help to modify behaviour to enhance the recovery of symptoms and physical activity. We conducted 14 semi-structured interviews to explore the barriers and facilitators to returning to physical activity in adults following a mild traumatic brain injury (TBI). The study design was informed by […]
Clinical Utility of the Sport Concussion Office Assessment Tool 6 (SCOAT6) and Other Select Multidomain Assessments for Subacute Sport-Related Concussion
CONCLUSIONS: The PCSI, timed tandem gait, and mVOMS components of the SCOAT6 were useful in identifying sport-related concussion. However, verbal cognitive tests, orthostatic vital signs, and clinical balance components were not useful for this purpose. The CP Screen, additional items from the full version of the VOMS, and ImPACT memory and processing speed were also […]
Persistent Post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies
INTRODUCTION: Persistent post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI) represents a growing global health challenge that significantly impacts patients' quality of life. Despite advances in acute concussion management, there remains a critical need for effective, evidence-based treatments for chronic PCS, as current interventions show limited success in addressing both symptoms and underlying pathophysiology.
Time-limited association between plasma transfusion and mortality in pediatric traumatic brain injury
CONCLUSION: This study reports a significant association between early plasma administration and a lower risk of 4-hour mortality among children with severe TBI that does not persist at or beyond 24 hours. While these data suggest that plasma resuscitation may extend the window for lifesaving intervention, additional prospective data are needed.
Comparing the sensitivity and specificity of novel motor assessments for traumatic brain injury
CONCLUSION: MMC-mediated tests are sensitive and specific (compared to traditional clinical tests) and have potential to fill a gap in clinical care of TBI.