Tag:

pathophysiology

Functional neurological disorders
Mechanical stress contributes to ligamentum flavum hypertrophy by inducing local inflammation and myofibroblast transition in the innovative surgical rabbit model

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Mechanisms of Ligamentum Flavum Hypertrophy The study delves into the complex changes that occur in …

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Movement Disorders
Tics and Parkinson’s Disease: Clinical and Pathophysiological Insights from a Rare Syndromic Association

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Understanding Tics in Parkinson’s Disease Tics are sudden, repetitive movements or vocalizations that can occur …

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Functional neurological disorders
Autoimmune psychosis: Psychopathological patterns and outcome after immunotherapy

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Autoimmune Psychosis Overview Autoimmune psychosis is an emerging area of interest in neurology and psychiatry, …

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Functional neurological disorders
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders

by myneuronews April 30, 2025

by myneuronews April 30, 2025

Microglia Replacement Strategy The study introduces an innovative approach to addressing neurological disorders through the …

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Movement Disorders
Arteriolosclerosis in CNS Tissues Outside the Cerebrum and Late-Life Motor Impairment

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Arteriolosclerosis in Non-Cerebral CNS Regions Arteriolosclerosis, a condition characterized by the thickening and hardening of …

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Headaches
Efficacy, safety, and tolerability of chenodeoxycholic acid (CDCA) in adult patients with cerebrotendinous xanthomatosis (RESTORE): a randomized withdrawal, double-blind, placebo-controlled, crossover phase 3 study

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Efficacy of Chenodeoxycholic Acid Chenodeoxycholic acid (CDCA) has emerged as a critical therapeutic option for …

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Functional neurological disorders
Silencer variants are key drivers of gene upregulation in Alzheimer’s disease

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Silencer Variants and Gene Regulation Recent advancements in genetic research have shed light on the …

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Traumatic brain injury
Retinal manifestations of traumatic brain injury

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Retinal Changes Associated with Traumatic Brain Injury Traumatic brain injury (TBI) can lead to various …

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Traumatic brain injury
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

by myneuronews April 28, 2025

by myneuronews April 28, 2025

Study Overview The research undertaken aimed to establish a reliable and straightforward model of mild …

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Functional neurological disorders
Milestone Review: Unlocking the Proteomics of Glycine Receptor Complexes

by myneuronews April 26, 2025

by myneuronews April 26, 2025

Proteomics Techniques in Glycine Receptor Analysis Understanding the complex interactions within neuronal proteins is critical …

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Understanding factors influencing the return to physical activity, perspectives of adults with concussion/mild traumatic brain injury: A qualitative study
Understanding the factors that influence the return to physical activity can help to modify behaviour to enhance the recovery of symptoms and physical activity. We conducted 14 semi-structured interviews to explore the barriers and facilitators to returning to physical activity in adults following a mild traumatic brain injury (TBI). The study design was informed by […]
Clinical Utility of the Sport Concussion Office Assessment Tool 6 (SCOAT6) and Other Select Multidomain Assessments for Subacute Sport-Related Concussion
CONCLUSIONS: The PCSI, timed tandem gait, and mVOMS components of the SCOAT6 were useful in identifying sport-related concussion. However, verbal cognitive tests, orthostatic vital signs, and clinical balance components were not useful for this purpose. The CP Screen, additional items from the full version of the VOMS, and ImPACT memory and processing speed were also […]
Persistent Post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies
INTRODUCTION: Persistent post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI) represents a growing global health challenge that significantly impacts patients' quality of life. Despite advances in acute concussion management, there remains a critical need for effective, evidence-based treatments for chronic PCS, as current interventions show limited success in addressing both symptoms and underlying pathophysiology.
Time-limited association between plasma transfusion and mortality in pediatric traumatic brain injury
CONCLUSION: This study reports a significant association between early plasma administration and a lower risk of 4-hour mortality among children with severe TBI that does not persist at or beyond 24 hours. While these data suggest that plasma resuscitation may extend the window for lifesaving intervention, additional prospective data are needed.
Comparing the sensitivity and specificity of novel motor assessments for traumatic brain injury
CONCLUSION: MMC-mediated tests are sensitive and specific (compared to traditional clinical tests) and have potential to fill a gap in clinical care of TBI.