Global trends and psychosocial effects of traumatic brain injury: A bibliometric and machine learning analysis
Global Trends in Traumatic Brain Injury The incidence of traumatic brain injury (TBI) has emerged as a significant public health […]
A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative
Definition and Classification of TBI Traumatic brain injury (TBI) is a complex and multifaceted condition resulting from external forces impacting
Raising the bar in migraine prevention: Toward freedom and optimal control
Current Approaches to Migraine Prevention Migraine prevention encompasses a variety of methodologies aimed at reducing the frequency, intensity, and duration
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Modelling and Standardisation of EHR Data for Mild Traumatic Brain Injury Patient Management
Background and Rationale The landscape of healthcare has witnessed a rapid transformation with the advent of electronic health records (EHRs),
Applying the ICRP model to writing recommendations in a neuropsychological evaluation for brain injury populations
Application of the ICRP Model The International Commission on Radiological Protection (ICRP) model serves as a crucial framework for understanding
Sex and Sport-Specific Differences on Baseline Concussion Balance Test Performance in Division-I Collegiate Athletes
Study Overview This investigation centers around the nuanced effects of sex and specific sports on baseline concussion balance test performance
Echoes of the Battlefield: Five-Year Longitudinal Cognitive Trajectories show Trend of Recovery for Deployment-related mild TBI in the LIMBIC-CENC Cohort
Cognitive Recovery Patterns The journey of cognitive recovery following a mild traumatic brain injury (mTBI) can exhibit varying pathways, influenced
On-Field Diagnosis and Management of Sports-Related Concussion in Pediatric Athletes
Understanding Concussion in Pediatric Athletes Concussions are a form of traumatic brain injury that occur when the brain undergoes a
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Early Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury
Early Pupil Abnormality and Its Significance Pupil abnormalities, such as asymmetry or non-reactivity to light, are crucial indicators in the
Exploring the Role of Salivary Biomarkers in Mild Traumatic Brain Injury Diagnosis
Abstract:
Mild Traumatic Brain Injury (mTBI) is a significant public health concern, with its diagnosis often hindered by subtle symptoms and limitations in traditional testing methods. Salivary biomarkers have emerged as a promising, non-invasive alternative for mTBI diagnosis. These biomarkers, including S100B protein, Neurofilament Light Chain (NfL), microRNAs (miRNAs), and extracellular vesicles (EVs), offer insights into neuroinflammatory processes and neuronal damage. Saliva’s accessibility and ease of collection position it as a cost-effective tool for early diagnosis and monitoring. Despite their potential, challenges such as standardization, biological complexity, and the need for validation persist. Advancements in research, technology, and integration with clinical tools could establish salivary biomarkers as a pivotal component in mTBI assessment, enabling more precise and personalized care.
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