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personalized care

Functional neurological disorders
Identification and Functional Analysis of Cystathionine Beta-Synthase Gene Mutations in Chinese Families with Classical Homocystinuria

by myneuronews April 29, 2025

by myneuronews April 29, 2025

Genetic Background of Homocystinuria Homocystinuria is a rare, inherited metabolic disorder primarily characterized by an …

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Biomarkers Traumatic brain injury
Exploring the Role of Salivary Biomarkers in Mild Traumatic Brain Injury Diagnosis

by Ioannis Mavroudis November 16, 2024

by Ioannis Mavroudis November 16, 2024

Abstract: Mild Traumatic Brain Injury (mTBI) is a significant public health concern, with its diagnosis …

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Aldehydic load as an objective imaging biomarker of mild traumatic brain injury
Mild traumatic brain injury (mTBI) is neurological impairment induced by biomechanical forces without structural brain damage, currently without an objective diagnostic tool. Downstream injury stems from oxidative damage leading to the production of neurotoxic aldehydes. A collagen-based 3D corticomimetic in vitro model of concussion was developed, confirming aldehyde production following impact. Total aldehyde levels were […]
Plasma levels of biomarkers associated with vasodilation and neuroinflammation in pediatric patients with head trauma and their relationship with clinical characteristics of patients
CONCLUSION: Evaluation of pediatric patients with head trauma together with these neuropeptides may provide great benefits in deciding whether to perform radiography such as CT. However, due to the relatively low sensitivities in ROC analysis and small sample size, further studies are warranted before they may be used as a screening test to distinguish CT-positive […]
Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures
Service members and law enforcement personnel are frequently exposed to blast overpressure during training and combat due to the use of heavy weaponry such as large-caliber rifles, explosives, and ordnance. The cumulative effects of these repeated low-level (
Trajectories of fear avoidance behavior and recovery after mild traumatic brain injury: Findings from the Toronto Concussion Study
CONCLUSION: Early fear avoidance behavior often decreases, but when it does not, it is associated with worse recovery from mTBI. These findings may inform the timing and design of interventions targeting fear avoidance behavior in patients with mTBI. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Proposed Reformulation of Brain Injury Criteria (BrIC) Using Head Rotation-Induced Brain Injury Thresholds Simulated and Derived Directly from A Subhuman Primate Finite Element Model
Recent studies have found that Brain Injury Criteria (BrIC) grossly overpredicts instances of real-world, severe traumatic brain injury (TBI). However, as it stands, BrIC is the leading candidate for a rotational head kinematics-based brain injury criteria for use in automotive regulation and general safety standards. This study attempts to understand why BrIC overpredicts the likelihood […]

personalized care

Identification and Functional Analysis of Cystathionine Beta-Synthase Gene Mutations in Chinese Families with Classical Homocystinuria

Exploring the Role of Salivary Biomarkers in Mild Traumatic Brain Injury Diagnosis