Tag:

personalized medicine

Dementia
Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Background and Rationale The intersection of depression and Alzheimer’s disease (AD) has garnered increasing attention …

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Headaches
Gepants in Primary Care: A Targeted Approach to Acute and Preventive Treatment of Migraine

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Gepants Mechanism of Action Gepants are a novel class of oral medications specifically designed to …

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Traumatic brain injury
Assessment of White Matter Changes Using Quantitative T1rho Mapping in an Open-Field Low-Intensity Blast Mouse Model of Mild Traumatic Brain Injury (mTBI)

by myneuronews June 26, 2025

by myneuronews June 26, 2025

Study Overview The study investigates the impact of mild traumatic brain injury (mTBI) on white …

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Traumatic brain injury
Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury

by myneuronews June 22, 2025

by myneuronews June 22, 2025

Injury-Specific Proteomic Signatures In recent research, a growing body of evidence has revealed that distinct …

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Dementia
Identification of diagnostic DNA methylation markers in the blood of Japanese Alzheimer’s disease patients using methylation capture sequencing

by myneuronews June 20, 2025

by myneuronews June 20, 2025

Study Overview The research aimed to uncover specific DNA methylation markers present in the blood …

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Traumatic brain injury
Neuroimaging of Mild Traumatic Injury

by myneuronews June 17, 2025

by myneuronews June 17, 2025

Neuroimaging Techniques Neuroimaging plays a pivotal role in the assessment and understanding of mild traumatic …

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Dementia
Retinal degeneration as an initial manifestation in a patient with neuronal intranuclear inclusion disease

by myneuronews June 14, 2025

by myneuronews June 14, 2025

Background of Retinal Degeneration Retinal degeneration encompasses a range of conditions characterized by the progressive …

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Traumatic brain injury
Resting-State Brain Activity Changes and Their Genetic Correlates in Mild Traumatic Brain Injury

by myneuronews June 13, 2025

by myneuronews June 13, 2025

Study Overview The investigation into resting-state brain activity alterations in individuals who have experienced mild …

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Dementia
Antiamyloid treatment for dementia: concerns outweigh hopes

by myneuronews June 13, 2025

by myneuronews June 13, 2025

Current State of Antiamyloid Treatments Throughout recent years, the focus on antiamyloid treatments as a …

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Traumatic brain injury
Transcranial Photobiomodulation Improves Cognitive Function, Post-Concussion, and PTSD Symptoms in Mild Traumatic Brain Injury

by myneuronews June 9, 2025

by myneuronews June 9, 2025

Cognitive Enhancements Transcranial photobiomodulation (TPBM) has emerged as a promising non-invasive intervention to enhance cognitive …

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Establishing the link between post-concussive symptoms and brain network dysfunction: A systematic scoping review of neuroimaging evidence
Mild traumatic brain injury (mTBI) is a prevalent condition with symptoms spanning physical, psychological, cognitive, and sleep domains. Altered functional brain networks have been implicated in mTBI, but the relationship between these network changes and post-concussive symptoms remains poorly understood. This study is a systematic scoping review, adhering to PRISMA-ScR guidelines, assessing current literature on […]
Effect of prior traumatic brain injury on Alzheimer's disease blood biomarkers in Vietnam Veterans
IMPORTANCE: Traumatic brain injury (TBI) is a risk factor for dementia and is known to impact levels of several Alzheimer's disease (AD) blood biomarkers. Plasma pTau217/ Aβ42 ratio has been reported to be 90% accurate for detection of brain amyloid in civilian cohorts.
Repeated Mild Head Injury Establishes a Senescent Cranial Bone Marrow Niche that Impairs Brain Metabolism
Traumatic brain injury (TBI) of any severity is associated with long-term systemic inflammation and increased risk of peripheral comorbidities, yet the mechanisms driving immune dysregulation and accelerated aging after repeated mild head impacts remain poorly defined. Here, we investigated the acute and chronic effects of repeated mild TBI (rmTBI) on distal and proximal bone marrow […]
Commentary on "Examining and Comparing the Clinical Characteristics of Adults with Persisting Post-Concussion Symptoms Presenting for Outpatient Rehabilitation Following a Mild Traumatic Brain Injury or a Minimal Head Injury"
No abstract
Cumulative effects of mild traumatic brain injury in the general population: persistent post-concussion symptoms and post-traumatic stress
CONCLUSIONS: Multiple mTBIs are linked to increased PPCS and PTSD/C-PTSD severity in the general population. Early identification and tailored interventions are essential to reduce long-term psychological and neurological effects.