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personalized medicine

Medical professionals Traumatic brain injury
Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

by Ioannis Mavroudis March 22, 2024

by Ioannis Mavroudis March 22, 2024

Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

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Medical professionals Traumatic brain injury
Brain Pathology in the Context of Concussion History

by Ioannis Mavroudis March 1, 2024

by Ioannis Mavroudis March 1, 2024

Exploring the intricate relationship between concussion history and brain pathology reveals a complex interplay of …

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Hidden Threat: A Delayed Diagnosis of an Intracranial Impacted Car Key Leading to Brain Abscess
Case Description A 32-year-old male presented to the emergency department with persistent headaches and episodes…
Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer’s disease: a large cohort study in UK biobank
Study Overview The research investigated the connections between diabetes mellitus, primary open-angle glaucoma (POAG), and…
A Proof-of-Concept Development on Speech Analysis for Concussion Detection
Study Overview This research project aims to explore the potential of speech analysis as a…
Reframing Functional Neurological Disorders in Modern Medicine
Understanding Functional Neurological Disorders Functional Neurological Disorders (FND) represent a category of neurological conditions where…
Youth Ages 4 to 13 Trends of Sports Concussions With Loss of Consciousness From 2014-2023 National Electronic Injury Surveillance System
Study Overview The study investigates the occurrence of sports-related concussions, specifically those leading to loss…

A Proof-of-Concept Development on Speech Analysis for Concussion Detection
Speech signal analysis to support objective clinical decision-making has gained immense interest, especially in neurological disorders. This research assessed the feasibility of speech analysis on the detection of concussions. Using a speech dataset from 82 concussed and 82 healthy participants, we extracted two speech feature sets focusing on Mel Frequency Cepstral Coefficients (MFCCs) to characterize […]
Youth Ages 4 to 13 Trends of Sports Concussions With Loss of Consciousness From 2014-2023 National Electronic Injury Surveillance System
CONCLUSION: The results of this study show a decrease in the overall level of LOC incidence in US youth athletes ages 4 to 13 years from 2014 to 2023 across 8 sports. The data delineate from previous studies that show an exponential increase in LOC incidence; however, the underlying reasons are still unclear and warrant […]
Development of the Common Cognitive Complaints after Concussion (C4) questionnaire: a treatment-planning tool for military service members and veterans with mild traumatic brain injury
CONCLUSION: The C4 adequately captured activity-level functional impairments common to mTBI, and clinicians endorsed its utility as a useful tool to personalize treatment targets.
Psychological Transdiagnostic Processes in Mild Traumatic Brain Injury Recovery: A Scoping Review
CONCLUSIONS: Although interest in TPs and mTBI recovery is growing, current investigations are centered on a narrow range of psychological constructs. Broader investigation of TPs known to maintain psychopathology and greater methodological consistency are needed.
Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
CONCLUSIONS: Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI.

personalized medicine

Unlocking the Molecular Secrets of Traumatic Brain Injury: A Path Toward Innovative Diagnostics and Therapies

Brain Pathology in the Context of Concussion History