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personalized medicine

Functional neurological disorders
Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features

by myneuronews July 18, 2025

by myneuronews July 18, 2025

Cerebellar Features and Their Role in Mental Illness The cerebellum, traditionally associated with coordination and …

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Headaches
Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy

by myneuronews July 18, 2025

by myneuronews July 18, 2025

Study Overview The research aimed to investigate the genetic factors influencing drug dosage adjustments during …

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Functional neurological disorders
OCNDS core features are conserved across variants, with loop-region mutations driving greater symptom burden

by myneuronews July 18, 2025

by myneuronews July 18, 2025

Core Features of OCNDS OCNDS, or Obsessive-Compulsive and Nervous System Disorders, presents a set of …

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Traumatic brain injury
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease

by myneuronews July 17, 2025

by myneuronews July 17, 2025

Study Overview The study aimed to explore the genetic underpinnings of Alzheimer’s disease (AD) through …

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Functional neurological disorders
Disordered Ru-O6 Octahedrons for Efficient and Selective Electro-oxidation of Sulfide to Sulfoxide via Boosted Surface Oxygen Kinetics

by myneuronews July 17, 2025

by myneuronews July 17, 2025

Mechanism of Electro-oxidation Electro-oxidation processes are fundamental in transforming chemical compounds, particularly in promoting desirable …

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Functional neurological disorders
A novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variants

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Novel Mechanism of Type 1 Von Willebrand Disease Recent research has uncovered a previously unrecognized …

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Functional neurological disorders
A novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variants

by myneuronews July 16, 2025

by myneuronews July 16, 2025

Novel Mechanism of Type 1 Von Willebrand Disease The study uncovers a previously unrecognized mechanism …

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Headaches
Aggressive Craniospinal Recurrence of a PTEN-Mutated Sinonasal Teratocarcinosarcoma: A Case Report

by myneuronews July 15, 2025

by myneuronews July 15, 2025

Case Presentation A 45-year-old male presented with a persistently obstructed nasal passage and occasional epistaxis …

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Functional neurological disorders
Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review

by myneuronews July 15, 2025

by myneuronews July 15, 2025

Neural Mechanisms in FND and Chronic Pain Research into the neural mechanisms underlying Functional Neurological …

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Functional neurological disorders
Immunological Correlation in Different Cutaneous Clinical Types of Lupus Erythematosus in the Bulgarian Population

by myneuronews July 14, 2025

by myneuronews July 14, 2025

Immunological Profile of Lupus Erythematosus The immunological profile of Lupus Erythematosus (LE) reveals a complex …

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Spontaneous Regression of Cranial Vault Lymphoma: A Case Report
Case Presentation A 54-year-old male patient, previously healthy with no notable medical history, presented with…
Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis
Study Overview The research aimed to investigate the role of TDP-43 accumulation in the progression…
Reframing Functional Neurological Disorders in Modern Medicine
Reframing the Understanding of FND Functional Neurological Disorder (FND) represents a complex interplay of neurological…
Inpatient cognitive analytic therapy for functional neurological disorder: A mixed methods four-phase single-case experimental design
Study Summary This study focused on evaluating the effectiveness of inpatient cognitive analytic therapy (CAT)…
Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT
Study Summary The Physio4FMD randomized controlled trial aimed to evaluate the effectiveness of specialist physiotherapy…

Youth Ages 4 to 13 Trends of Sports Concussions With Loss of Consciousness From 2014-2023 National Electronic Injury Surveillance System
CONCLUSION: The results of this study show a decrease in the overall level of LOC incidence in US youth athletes ages 4 to 13 years from 2014 to 2023 across 8 sports. The data delineate from previous studies that show an exponential increase in LOC incidence; however, the underlying reasons are still unclear and warrant […]
Development of the Common Cognitive Complaints after Concussion (C4) questionnaire: a treatment-planning tool for military service members and veterans with mild traumatic brain injury
CONCLUSION: The C4 adequately captured activity-level functional impairments common to mTBI, and clinicians endorsed its utility as a useful tool to personalize treatment targets.
Psychological Transdiagnostic Processes in Mild Traumatic Brain Injury Recovery: A Scoping Review
CONCLUSIONS: Although interest in TPs and mTBI recovery is growing, current investigations are centered on a narrow range of psychological constructs. Broader investigation of TPs known to maintain psychopathology and greater methodological consistency are needed.
Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
CONCLUSIONS: Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI.
Multidisciplinary rehabilitation and follow-up for children hospitalized with traumatic brain injury
PurposeMost children hospitalized with traumatic brain injury (TBI) acquire new impairments that impact function and health-related quality of life. However, there is a lack of standardized, multidisciplinary, longitudinal rehabilitative services for children with TBI.MethodsThis single center, retrospective study evaluated rehabilitative services during acute hospitalization and identified the frequency of unmet needs, defined as new or […]