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personalized medicine

Functional neurological disorders
Role of ALOX5AP in the pathogenesis of cerebral small vessel disease: impact of inflammation and lipid metabolism dysregulation

by myneuronews July 12, 2025

by myneuronews July 12, 2025

Pathophysiological Mechanisms of ALOX5AP ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein) plays a pivotal role in the pathophysiology …

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Functional neurological disorders
Creutzfeldt-Jakob Disease in South Texas: A Case Series of Three Hispanic Patients

by myneuronews July 11, 2025

by myneuronews July 11, 2025

Understanding Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease (CJD) is a rare but severe neurodegenerative condition classified under …

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Functional neurological disorders
Analysis of biased allelic enhancer activity of schizophrenia-linked common variants

by myneuronews July 10, 2025

by myneuronews July 10, 2025

Biased Enhancer Activity in Schizophrenia Research in recent years has increasingly pointed to the pivotal …

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Functional neurological disorders
Analysis of biased allelic enhancer activity of schizophrenia-linked common variants

by myneuronews July 10, 2025

by myneuronews July 10, 2025

Biased allelic enhancer activity in schizophrenia Recent findings have highlighted the complexity of genetic factors …

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Functional neurological disorders
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion

by myneuronews July 9, 2025

by myneuronews July 9, 2025

Population Genetics of Chromosome 22q11.2 Chromosome 22q11.2 is a genomic region that has garnered significant …

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Traumatic brain injury
Reconsidering cognitive outcome one year after mild traumatic brain injury: Secondary analysis of TRACK-TBI data

by myneuronews July 9, 2025

by myneuronews July 9, 2025

Cognitive Outcomes Post-Injury Mild traumatic brain injury (mTBI) can lead to a range of cognitive …

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Traumatic brain injury
Editorial: Rehabilitation interventions for mild traumatic brain injury

by myneuronews July 9, 2025

by myneuronews July 9, 2025

Rehabilitation Approaches Rehabilitation for mild traumatic brain injury (mTBI) employs a variety of strategies, tailored …

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Dementia
Early outpatient clinical experience with xanomeline and trospium chloride for schizophrenia: a case report

by myneuronews July 7, 2025

by myneuronews July 7, 2025

Study Overview This article presents a detailed examination of the early outpatient clinical experiences involving …

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Functional neurological disorders
Retrospective Analysis of Factors Associated with a Prolonged Nucleic Acid Conversion Time in Patients with COVID-19 at Fangcang Shelter Hospital

by myneuronews July 7, 2025

by myneuronews July 7, 2025

Background of Nucleic Acid Conversion in COVID-19 The process of nucleic acid conversion in COVID-19 …

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Functional neurological disorders
Wogonin Inhibits Oxidative Stress in Hypoxia-Induced hCMEC/D3 Cells Through Suppressing CXCL8-Mediated TLR4/NF-κB Pathway

by myneuronews July 4, 2025

by myneuronews July 4, 2025

Mechanisms of Wogonin in Oxidative Stress Wogonin, a naturally occurring flavonoid found in various plants, …

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Spontaneous Regression of Cranial Vault Lymphoma: A Case Report
Case Presentation A 54-year-old male patient, previously healthy with no notable medical history, presented with…
Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis
Study Overview The research aimed to investigate the role of TDP-43 accumulation in the progression…
Reframing Functional Neurological Disorders in Modern Medicine
Reframing the Understanding of FND Functional Neurological Disorder (FND) represents a complex interplay of neurological…
Inpatient cognitive analytic therapy for functional neurological disorder: A mixed methods four-phase single-case experimental design
Study Summary This study focused on evaluating the effectiveness of inpatient cognitive analytic therapy (CAT)…
Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT
Study Summary The Physio4FMD randomized controlled trial aimed to evaluate the effectiveness of specialist physiotherapy…

Youth Ages 4 to 13 Trends of Sports Concussions With Loss of Consciousness From 2014-2023 National Electronic Injury Surveillance System
CONCLUSION: The results of this study show a decrease in the overall level of LOC incidence in US youth athletes ages 4 to 13 years from 2014 to 2023 across 8 sports. The data delineate from previous studies that show an exponential increase in LOC incidence; however, the underlying reasons are still unclear and warrant […]
Development of the Common Cognitive Complaints after Concussion (C4) questionnaire: a treatment-planning tool for military service members and veterans with mild traumatic brain injury
CONCLUSION: The C4 adequately captured activity-level functional impairments common to mTBI, and clinicians endorsed its utility as a useful tool to personalize treatment targets.
Psychological Transdiagnostic Processes in Mild Traumatic Brain Injury Recovery: A Scoping Review
CONCLUSIONS: Although interest in TPs and mTBI recovery is growing, current investigations are centered on a narrow range of psychological constructs. Broader investigation of TPs known to maintain psychopathology and greater methodological consistency are needed.
Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
CONCLUSIONS: Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI.
Multidisciplinary rehabilitation and follow-up for children hospitalized with traumatic brain injury
PurposeMost children hospitalized with traumatic brain injury (TBI) acquire new impairments that impact function and health-related quality of life. However, there is a lack of standardized, multidisciplinary, longitudinal rehabilitative services for children with TBI.MethodsThis single center, retrospective study evaluated rehabilitative services during acute hospitalization and identified the frequency of unmet needs, defined as new or […]