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personalized medicine

Functional neurological disorders
DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function

by myneuronews May 14, 2025

by myneuronews May 14, 2025

Mechanisms of DG9 Action DG9 has emerged as a pivotal compound in the realm of …

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Functional neurological disorders
Research Progress on BDNF and Depression

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Understanding BDNF’s Role in Depression Brain-derived neurotrophic factor (BDNF) is a protein that plays a …

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Functional neurological disorders
Research Progress on BDNF and Depression

by myneuronews May 13, 2025

by myneuronews May 13, 2025

Understanding BDNF in Depression Brain-Derived Neurotrophic Factor (BDNF) is a crucial protein that supports the …

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Functional neurological disorders
Apolipoprotein E (APOE) and Alzheimer’s disease risk in a Ugandan population: A pilot case-control study

by myneuronews May 12, 2025

by myneuronews May 12, 2025

Apolipoprotein E Genotypes and Alzheimer’s Disease The study investigated the relationship between different genotypes of …

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Functional neurological disorders
Handwriting, touchscreen dexterity and bradykinesia measures in Parkinson’s disease: a feature selection study

by myneuronews May 11, 2025

by myneuronews May 11, 2025

Background on Parkinson’s Disease and Motor Symptoms Parkinson’s disease is a progressive neurodegenerative disorder primarily …

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Traumatic brain injury
Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

by myneuronews May 10, 2025

by myneuronews May 10, 2025

Pathological tau phosphorylation mechanisms Tau is a critical protein in the brain, primarily known for …

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Dementia
Unraveling sex differences in Alzheimer’s disease and related endophenotypes with brain proteomes

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Research Context The study of Alzheimer’s disease (AD) has gained considerable momentum as researchers explore …

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Functional neurological disorders
Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Electrophysiological Properties of hiPSC-Derived Neurons The study begins by examining the electrophysiological properties of human-induced …

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Functional neurological disorders
Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

by myneuronews May 9, 2025

by myneuronews May 9, 2025

Background and Rationale The treatment and study of Parkinson’s disease (PD) continue to evolve, particularly …

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Functional neurological disorders
Genetic Sketch of Parkinson’s Disease in India

by myneuronews May 7, 2025

by myneuronews May 7, 2025

Genetic Factors in Parkinson’s Disease Parkinson’s Disease (PD) is a multifactorial neurological disorder, with both …

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Understanding factors influencing the return to physical activity, perspectives of adults with concussion/mild traumatic brain injury: A qualitative study
Understanding the factors that influence the return to physical activity can help to modify behaviour to enhance the recovery of symptoms and physical activity. We conducted 14 semi-structured interviews to explore the barriers and facilitators to returning to physical activity in adults following a mild traumatic brain injury (TBI). The study design was informed by […]
Clinical Utility of the Sport Concussion Office Assessment Tool 6 (SCOAT6) and Other Select Multidomain Assessments for Subacute Sport-Related Concussion
CONCLUSIONS: The PCSI, timed tandem gait, and mVOMS components of the SCOAT6 were useful in identifying sport-related concussion. However, verbal cognitive tests, orthostatic vital signs, and clinical balance components were not useful for this purpose. The CP Screen, additional items from the full version of the VOMS, and ImPACT memory and processing speed were also […]
Persistent Post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies
INTRODUCTION: Persistent post-concussion syndrome (PCS) following mild traumatic brain injury (mTBI) represents a growing global health challenge that significantly impacts patients' quality of life. Despite advances in acute concussion management, there remains a critical need for effective, evidence-based treatments for chronic PCS, as current interventions show limited success in addressing both symptoms and underlying pathophysiology.
Time-limited association between plasma transfusion and mortality in pediatric traumatic brain injury
CONCLUSION: This study reports a significant association between early plasma administration and a lower risk of 4-hour mortality among children with severe TBI that does not persist at or beyond 24 hours. While these data suggest that plasma resuscitation may extend the window for lifesaving intervention, additional prospective data are needed.
Comparing the sensitivity and specificity of novel motor assessments for traumatic brain injury
CONCLUSION: MMC-mediated tests are sensitive and specific (compared to traditional clinical tests) and have potential to fill a gap in clinical care of TBI.