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personalized medicine

Functional neurological disorders
Unveiling cortical criticality changes along the prodromal to the overt continuum of alpha-synucleinopathy

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Cortical Criticality in Alpha-Synucleinopathy The concept of cortical criticality refers to the brain’s ability to …

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Traumatic brain injury
Linked alterations in structure and autoimmunity biomarkers in remote mild-to-moderate TBI: A multi-modal brain imaging study

by myneuronews July 3, 2025

by myneuronews July 3, 2025

Study Overview This research focused on the relationship between structural brain alterations and autoimmunity biomarkers …

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Functional neurological disorders
What does a migraine aura look like?-A systematic review

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Migraine Aura Characteristics Migraine aura is a fascinating phenomenon that can manifest in various ways, …

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Functional neurological disorders
A dynamic prediction model for predicting the time at which patients with MCI progress to AD based on time-dependent covariates

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Dynamic Prediction Model Overview The study introduces a dynamic prediction model aimed at forecasting the …

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Functional neurological disorders
Identification of comorbid genes between type 2 diabetes and migraine through peripheral blood single-cell and Mendelian randomization analysis

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Comorbid Gene Identification The identification of comorbid genes linking type 2 diabetes and migraine is …

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Functional neurological disorders
Development of a novel liquid chromatography-tandem mass spectrometry based enzymatic assay of 5,10-methylenetetrahydrofolate reductase

by myneuronews July 2, 2025

by myneuronews July 2, 2025

Enzymatic Assay Development The development of a novel enzymatic assay for 5,10-methylenetetrahydrofolate reductase (MTHFR) taps …

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Dementia
Uncovering Putative Causal Non-Coding RNAs in Acute and Chronic Myeloid Leukemia: A Genome-Wide Mendelian Randomization Study

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Study Overview The investigation aimed to explore the role of non-coding RNAs in the development …

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Functional neurological disorders
Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Orbitofrontal Thickness as a Biomarker The orbitofrontal cortex (OFC) has emerged as a critical area …

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Functional neurological disorders
Modulation of conformational features and oligomerization of MMACHC by cobalamin variants: impact of the R161Q mutation in cblC disease

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Conformational Features of MMACHC The study delves into the conformational characteristics of MMACHC, a protein …

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Functional neurological disorders
Lesion distribution and network mapping in dyskinetic cerebral palsy

by myneuronews June 27, 2025

by myneuronews June 27, 2025

Lesion Characteristics in Dyskinetic Cerebral Palsy In dyskinetic cerebral palsy, the distribution of lesions is …

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Spontaneous Regression of Cranial Vault Lymphoma: A Case Report
Case Presentation A 54-year-old male patient, previously healthy with no notable medical history, presented with…
Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis
Study Overview The research aimed to investigate the role of TDP-43 accumulation in the progression…
Reframing Functional Neurological Disorders in Modern Medicine
Reframing the Understanding of FND Functional Neurological Disorder (FND) represents a complex interplay of neurological…
Inpatient cognitive analytic therapy for functional neurological disorder: A mixed methods four-phase single-case experimental design
Study Summary This study focused on evaluating the effectiveness of inpatient cognitive analytic therapy (CAT)…
Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT
Study Summary The Physio4FMD randomized controlled trial aimed to evaluate the effectiveness of specialist physiotherapy…

Youth Ages 4 to 13 Trends of Sports Concussions With Loss of Consciousness From 2014-2023 National Electronic Injury Surveillance System
CONCLUSION: The results of this study show a decrease in the overall level of LOC incidence in US youth athletes ages 4 to 13 years from 2014 to 2023 across 8 sports. The data delineate from previous studies that show an exponential increase in LOC incidence; however, the underlying reasons are still unclear and warrant […]
Development of the Common Cognitive Complaints after Concussion (C4) questionnaire: a treatment-planning tool for military service members and veterans with mild traumatic brain injury
CONCLUSION: The C4 adequately captured activity-level functional impairments common to mTBI, and clinicians endorsed its utility as a useful tool to personalize treatment targets.
Psychological Transdiagnostic Processes in Mild Traumatic Brain Injury Recovery: A Scoping Review
CONCLUSIONS: Although interest in TPs and mTBI recovery is growing, current investigations are centered on a narrow range of psychological constructs. Broader investigation of TPs known to maintain psychopathology and greater methodological consistency are needed.
Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
CONCLUSIONS: Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI.
Multidisciplinary rehabilitation and follow-up for children hospitalized with traumatic brain injury
PurposeMost children hospitalized with traumatic brain injury (TBI) acquire new impairments that impact function and health-related quality of life. However, there is a lack of standardized, multidisciplinary, longitudinal rehabilitative services for children with TBI.MethodsThis single center, retrospective study evaluated rehabilitative services during acute hospitalization and identified the frequency of unmet needs, defined as new or […]